PMP22 and OPRM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PMP22	OPRM1
Description		peripheral myelin protein 22	opioid receptor mu 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Bicellular Tight Junction Membrane Compact Myelin Synapse	Cytoplasm Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Axon Dendrite Cell Projection Neuron Projection Perikaryon Synapse
	Molecular Function	Protein Binding	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Beta-endorphin Receptor Activity G Protein-coupled Opioid Receptor Activity Voltage-gated Calcium Channel Activity Protein Binding G Protein-coupled Peptide Receptor Activity G-protein Beta-subunit Binding Morphine Receptor Activity Neuropeptide Binding
	Biological Process	Apoptotic Process Chemical Synaptic Transmission Nervous System Development Peripheral Nervous System Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Projection Development Cell Differentiation Bleb Assembly Myelin Assembly Myelination	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Sensory Perception Negative Regulation Of Cell Population Proliferation Sensory Perception Of Pain G Protein-coupled Opioid Receptor Signaling Pathway Negative Regulation Of Nitric Oxide Biosynthetic Process Behavioral Response To Ethanol Positive Regulation Of Neurogenesis Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Wnt Protein Secretion Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Cellular Response To Morphine Regulation Of Cellular Response To Stress Regulation Of NMDA Receptor Activity
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination	Opioid Signalling G-protein activation Peptide ligand-binding receptors G alpha (i) signalling events Interleukin-4 and Interleukin-13 signaling MECP2 regulates neuronal receptors and channels
Drugs			Tramadol Morphine Codeine Amitriptyline Hydromorphone Methadone Meperidine Oxycodone Levallorphan Dextromethorphan Butorphanol Dextropropoxyphene Pentazocine Naltrexone Sufentanil Alfentanil Fentanyl Loperamide Nalbuphine Levorphanol Remifentanil Ondansetron Anileridine Buprenorphine Hydrocodone Diphenoxylate Naloxone Oxymorphone Dezocine Ketamine Levacetylmethadol Aripiprazole Methadyl acetate 3-Methylthiofentanyl Dimethylthiambutene Diamorphine Ethylmorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl V1003 Epicept NP-1 LI-301 Tapentadol Nalmefene Alvimopan Amisulpride Morphine glucuronide Ketobemidone Methylnaltrexone Naloxegol Cannabidiol Trimebutine Butyrfentanyl Pholcodine Eluxadoline Tianeptine Opium Pentoxyverine Naldemedine Samidorphan Metenkefalin Medical Cannabis Nabiximols Loxicodegol Oliceridine
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Allergic rhinitis ( 25085501) Amyotrophic lateral sclerosis ( 29566793) Corneal structure ( 23291589) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Preterm birth (maternal effect) ( 28877031) Resting heart rate ( 27798624)	Adult body size ( 32376654) Body size at age 10 ( 32376654) Diastolic blood pressure ( 30224653) HDL cholesterol levels ( 32203549) Hypertension ( 21347282) Lipoprotein (a) levels ( 26377243) Menstruation quality of life impact (fever) ( 29855537) Methadone dose in opioid dependence ( 28115739) Nontraumatic osteonecrosis of the femoral head ( 32701715) Opioid use disorder ( 32492095) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		64 interacting genes: APOL3 AQP6 ARL13B ASGR2 ATP6AP2 BIK C16orf54 CANX CD3G CD53 CD69 CEACAM3 CLDN18 CLDN5 CLDN6 CLEC12B CLEC14A CREB3 CREB3L1 DDX52 EBP EDA EMP1 ERGIC3 FAM209A FCGRT FFAR2 GJA8 GPR42 GPR61 GPRC5D GPX8 IFNGR2 KCNJ6 KCNN4 KLRC1 LMNA MPZ MS4A7 OPRM1 PDZK1IP1 PEX19 PGRMC2 REEP4 SAR1A SCN3B SDC4 SHISAL1 SLC10A1 SLC18A1 SLC38A1 SMIM3 SPACA1 STOM SYT2 TLCD4 TM4SF18 TM4SF19 TMEM139 TMEM14B TMEM30B TMEM31 TMX1 TSPAN12	78 interacting genes: ADAM33 ADD3 ALOX5AP ATP6V0C ATP6V0E1 C2CD2L CALM1 CCDC167 CD302 CLCN7 CLDN10 CLDN22 CLDN8 CLEC12B CLEC7A CNIH1 COPS5 CPLX1 CTXN3 CYB561 DNAJB4 DOK4 DOK5 DRD2 EHHADH EMP1 EMP3 FLNA GJA4 GNA15 GNAI1 GNAI2 GNAO1 GPRASP1 GRK3 GRM1 HS6ST1 IFITM3 KCNF1 LAT LPAR3 LRRC25 MAL MALL MAP1LC3A MAP1LC3C MFF NELFA NSG1 OPRD1 OPRL1 PLD2 PLD3 PMP22 PPL RPRM RTP4 SCGB1D1 SEC22A SERP2 SIAH1 SIAH2 SLC30A2 SLC38A7 SLC39A13 SLC41A1 SLC9A9 SMAGP TEX264 TM4SF4 TMBIM6 TMEM236 TRARG1 UBC VAPA WLS YIPF3 ZYX
Entrez ID		5376	4988
HPRD ID		03059	02484
Ensembl ID		ENSG00000109099	ENSG00000112038
Uniprot IDs		A0A2R8Y5L5 A8MU75 Q01453 Q6FH25	A0A6H0WF09 B8K2Q5 G8XRH4 G8XRH5 L0E130 P35372
PDB IDs			8EF5 8EF6 8EFB 8EFL 8EFO 8EFQ 8F7Q 8F7R 8K9K 8K9L 9MQH 9MQI 9MQJ
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Protein Binding Carbohydrate Binding External Side Of Plasma Membrane Natural Killer Cell Inhibitory Signaling Pathway Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Endoplasmic Reticulum Membrane Endoplasmic Reticulum	Membrane Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Plasma Membrane Bleb Assembly Cytoplasmic Vesicle Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Protein Binding Intracellular Monoatomic Cation Homeostasis Heterotrimeric G-protein Complex Intracellular Monoatomic Ion Homeostasis G Protein-coupled Receptor Binding Lysosomal Membrane Monoatomic Cation Homeostasis G Protein-coupled Serotonin Receptor Binding Monoatomic Ion Homeostasis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transport Adenylate Cyclase Regulator Activity Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Monoatomic Cation Transport G Protein-coupled Dopamine Receptor Signaling Pathway Intracellular Chemical Homeostasis Transmembrane Transport Regulation Of Metal Ion Transport Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Monoatomic Ion Transport Endoplasmic Reticulum Membrane Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Bicellular Tight Junction Inorganic Ion Transmembrane Transport Phospholipase D Activity Cell-cell Signaling Membrane Raft Distribution G Protein-coupled Opioid Receptor Activity Anchoring Junction Monoatomic Ion Transmembrane Transport Chemical Synaptic Transmission Signaling Membrane Raft Localization Cellular Homeostasis Vesicle-mediated Transport Neuron-neuron Synaptic Transmission G Protein-coupled Opioid Receptor Signaling Pathway Proton-transporting V-type ATPase, V0 Domain Cell Communication
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