MYO9B and LRRC41

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MYO9B	LRRC41
Description		myosin IXB	leucine rich repeat containing 41
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Cytoskeleton Actin Filament Cell Cortex Actin Cytoskeleton Membrane Myosin Complex Lamellipodium Perinuclear Region Of Cytoplasm Postsynaptic Actin Cytoskeleton	Nucleus Cytoplasm Cytosol Membrane
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding GTPase Activator Activity Protein Binding Calmodulin Binding ATP Binding Zinc Ion Binding ATP Hydrolysis Activity Small GTPase Binding Protein Homodimerization Activity ADP Binding Metal Ion Binding Roundabout Binding Actin Filament Binding	Protein Binding Identical Protein Binding
	Biological Process	Signal Transduction Rho Protein Signal Transduction Actin Filament-based Movement ARF Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Roundabout Signaling Pathway Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Lamellipodium Morphogenesis	Protein Ubiquitination
Pathways		Regulation of actin dynamics for phagocytic cup formation RHOA GTPase cycle SLIT2:ROBO1 increases RHOA activity RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOF GTPase cycle FCGR3A-mediated phagocytosis	Neddylation RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		A body shape index ( 34021172) Appendicular lean mass ( 33097823) Asthma ( 32296059) Coronary artery disease ( 33020668 29212778) Diastolic blood pressure ( 27841878) Glycated hemoglobin levels ( 24647736 28898252 34059833) Height ( 31562340 29782485 20881960) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494 27863252 29403010) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Night sleep phenotypes ( 27126917) Platelet count ( 29403010 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Prostate cancer ( 29892016) Prostate cancer (early onset) ( 29892016) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Selective IgA deficiency ( 27723758) Spleen volume ( 34128465) Systolic blood pressure ( 30578418 27841878) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 28552196)	Body mass index ( 26426971)
Interacting Genes		6 interacting genes: ACTA1 ARFGEF1 CALM1 LRRC41 MOB4 PKN2	11 interacting genes: CYSRT1 ELOB ELOC FHL5 KRT31 KRT34 KRTAP3-1 KRTAP6-2 MYO9B RBPMS UBC
Entrez ID		4650	10489
HPRD ID		03677	10102
Ensembl ID		ENSG00000099331	ENSG00000132128
Uniprot IDs		B0I1T6 Q13459 Q8WVD2	Q15345
PDB IDs		5C5S 5HPY
Enriched GO Terms of Interacting Partners?		Myosin Binding Cytoplasm Cytoskeleton Lamellipodium Sarcomere Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Mitochondrion-endoplasmic Reticulum Membrane Tethering Regulation Of Synaptic Plasticity Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Membrane Docking Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cell Division Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Autophagosome Membrane Docking Regulation Of Cytokinesis Centrosome Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Vesicle-mediated Transport In Synapse Organelle Localization By Membrane Tethering Golgi Vesicle Fusion To Target Membrane Golgi Organization Midbody Exocytosis Perinuclear Region Of Cytoplasm Endomembrane System Organization Negative Regulation Of Voltage-gated Calcium Channel Activity Apical Junction Assembly Striated Muscle Thin Filament Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Neurotransmitter Receptor Transport To Postsynaptic Membrane Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane	Intermediate Filament Target-directed MiRNA Degradation Elongin Complex Keratin Filament Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing MiRNA Catabolic Process Cul5-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Epidermis Development MiRNA Metabolic Process Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing Structural Molecule Activity Transcription Initiation At RNA Polymerase II Promoter Transcription Corepressor Binding Structural Constituent Of Skin Epidermis ARF Protein Signal Transduction Cytosol Intermediate Filament Organization DNA-templated Transcription Initiation Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process VCB Complex Ubiquitin Ligase Complex MRNA CDS Binding Roundabout Signaling Pathway Post-transcriptional Gene Silencing Roundabout Binding Lamellipodium Morphogenesis Protein Ubiquitination Postsynaptic Actin Cytoskeleton RNA Catabolic Process Pre-mRNA Intronic Binding Protein Modification By Small Protein Conjugation
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