MYO9B

Name	myosin IXB
Structure
Novel Interactors	1 novel interactors: RAB8A
Interactors	6 interactors: ACTA1 ARFGEF1 CALM1 LRRC41 MOB4 PKN2
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Cytoskeleton Actin Filament Cell Cortex Actin Cytoskeleton Membrane Myosin Complex Lamellipodium Perinuclear Region Of Cytoplasm Postsynaptic Actin Cytoskeleton
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding GTPase Activator Activity Protein Binding Calmodulin Binding ATP Binding Zinc Ion Binding ATP Hydrolysis Activity Small GTPase Binding Protein Homodimerization Activity ADP Binding Metal Ion Binding Roundabout Binding Actin Filament Binding
	Biological Process	Signal Transduction Rho Protein Signal Transduction Actin Filament-based Movement ARF Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Roundabout Signaling Pathway Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Lamellipodium Morphogenesis
Pathways	Regulation of actin dynamics for phagocytic cup formation RHOA GTPase cycle SLIT2:ROBO1 increases RHOA activity RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOF GTPase cycle FCGR3A-mediated phagocytosis
GWAS	A body shape index ( 34021172 ) Appendicular lean mass ( 33097823 ) Asthma ( 32296059 ) Coronary artery disease ( 33020668 29212778 ) Diastolic blood pressure ( 27841878 ) Glycated hemoglobin levels ( 24647736 28898252 34059833 ) Height ( 31562340 29782485 20881960 ) hemolysis of donated blood (osmotic) ( 34014839 ) High light scatter reticulocyte count ( 32888494 27863252 ) High light scatter reticulocyte percentage of red cells ( 32888494 27863252 ) Mean corpuscular hemoglobin concentration ( 32888494 27863252 29403010 ) Mean corpuscular volume ( 27863252 32888494 ) Mean platelet volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Night sleep phenotypes ( 27126917 ) Platelet count ( 29403010 32888494 27863252 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 32888494 27863252 ) Prostate cancer ( 29892016 ) Prostate cancer (early onset) ( 29892016 ) Red cell distribution width ( 27863252 28957414 32888494 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) Selective IgA deficiency ( 27723758 ) Spleen volume ( 34128465 ) Systolic blood pressure ( 30578418 27841878 ) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 28552196 )
Entrez ID	4650
HPRD ID	03677
Ensembl ID	ENSG00000099331
Uniprot IDs	B0I1T6 Q13459 Q8WVD2
PDB IDs	5C5S 5HPY
GO Terms Enriched among Interactors ?	Myosin Binding Cytoplasm Cytoskeleton Lamellipodium Sarcomere Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Mitochondrion-endoplasmic Reticulum Membrane Tethering Regulation Of Synaptic Plasticity Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Membrane Docking Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cell Division Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Autophagosome Membrane Docking Regulation Of Cytokinesis Centrosome Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Vesicle-mediated Transport In Synapse Organelle Localization By Membrane Tethering Golgi Vesicle Fusion To Target Membrane Golgi Organization Midbody Exocytosis Perinuclear Region Of Cytoplasm Endomembrane System Organization Negative Regulation Of Voltage-gated Calcium Channel Activity Apical Junction Assembly Striated Muscle Thin Filament Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Neurotransmitter Receptor Transport To Postsynaptic Membrane Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane