DNASE1 and ACTA2

Number of citations: 0 (PubMedID 11707283)
Data Source: HPRD (in vitro)

		DNASE1	ACTA2
Name		deoxyribonuclease 1	actin alpha 2, smooth muscle
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Envelope Cytoplasmic Vesicle Zymogen Granule Extracellular Exosome	Stress Fiber Basement Membrane Extracellular Space Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Lamellipodium Filopodium Smooth Muscle Contractile Fiber Motile Cilium Protein-containing Complex Cell Body Extracellular Exosome
	Molecular Function	DNA Binding Actin Binding Catalytic Activity Nuclease Activity Endonuclease Activity Deoxyribonuclease I Activity DNA Nuclease Activity Protein Binding Hydrolase Activity	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity Protein Kinase Binding
	Biological Process	Neutrophil Activation Involved In Immune Response Regulation Of Acute Inflammatory Response DNA Catabolic Process Apoptotic Process Regulation Of Neutrophil Mediated Cytotoxicity	Muscle Contraction Regulation Of Blood Pressure Response To Virus Positive Regulation Of Gene Expression Vascular Associated Smooth Muscle Contraction Positive Regulation Of Hepatic Stellate Cell Migration Positive Regulation Of Hepatic Stellate Cell Contraction Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Transforming Growth Factor Beta Stimulus Juxtaglomerular Apparatus Development Glomerular Mesangial Cell Development Mesenchyme Migration Positive Regulation Of Hepatic Stellate Cell Activation
Pathways		None	Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Mammary Gland Myoepithelial Cells
Drugs		None	Phenethyl Isothiocyanate
Diseases		None	Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		Body mass index ( 29273807 ) Monocyte percentage of white cells ( 32888494 )	Arthritis (juvenile idiopathic) ( 33106285 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Chronic lymphocytic leukemia ( 23770605 26956414 ) Immunoglobulin A ( 20694011 ) Lymphocyte percentage of white cells ( 32888494 ) Pulse pressure ( 30578418 ) Selective IgA deficiency ( 27723758 )
Novel Interactors		1 novel interactors: TSC22D1	None recorded
Interacting Genes		4 interacting genes: ACTA1 ACTA2 ACTB ACTG1	18 interacting genes: CCT4 CCT5 CFL1 CREBBP DNASE1 EP300 GC MINK1 MYL1 MYOC PCYT1B PRKCD SELE SHBG SNTA1 TMSB4X UBE3A YBX1
Entrez ID		1773	59
HPRD ID		00509	00031
Ensembl ID		ENSG00000213918	ENSG00000107796
Uniprot IDs		P24855	A0AAQ5BGG7 A0AAQ5BGI6 D2JYH4 P62736
PDB IDs		4AWN	Not available
GO Terms Enriched among Interactors		Actin Cytoskeleton Mesenchyme Migration Regulation Of Transepithelial Transport Dense Body Actin Filament Structural Constituent Of Postsynaptic Actin Cytoskeleton Morphogenesis Of A Polarized Epithelium Structural Constituent Of Cytoskeleton Blood Microparticle Postsynaptic Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Lamellipodium Postsynaptic Cytoskeleton Organization Regulation Of Synaptic Vesicle Endocytosis NuA4 Histone Acetyltransferase Complex Apical Junction Complex Regulation Of Synaptic Vesicle Recycling Maintenance Of Blood-brain Barrier Positive Regulation Of Macromolecule Biosynthetic Process Platelet Aggregation Positive Regulation Of Biosynthetic Process Homotypic Cell-cell Adhesion Protein Kinase Binding Positive Regulation Of Macromolecule Metabolic Process ATP Binding Filopodium Cytoskeleton Cell Body Extracellular Space Stress Fiber Positive Regulation Of Hepatic Stellate Cell Contraction Protein Localization To Cell Junction Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Positive Regulation Of Metabolic Process Schaffer Collateral - CA1 Synapse Hydrolase Activity Nucleotide Binding Cell-cell Junction Assembly Positive Regulation Of Hepatic Stellate Cell Migration Regulation Of Norepinephrine Uptake Axonogenesis Juxtaglomerular Apparatus Development Transporter Regulator Activity Extracellular Exosome Cell-cell Junction Organization Glomerular Mesangial Cell Development Smooth Muscle Contractile Fiber	Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization Regulation Of Protein Localization To Nucleus Histone H3K27 Acetyltransferase Activity Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Protein Stabilization Regulation Of Biological Quality Extracellular Exosome Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Cytoskeleton Organization Regulation Of Protein Localization Actin Binding Regulation Of Protein Stability Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex N-terminal Protein Amino Acid Acetylation Regulation Of Telomerase RNA Localization To Cajal Body Peptidyl-lysine Acetylation Cellular Response To UV Regulation Of Cell Adhesion Regulation Of Organelle Organization Regulation Of Cellular Response To Heat Regulation Of Actin Filament Organization Regulation Of Defense Response Intracellular Signaling Cassette Acetyltransferase Activity Positive Regulation Of DNA Metabolic Process Cellular Response To Light Stimulus Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Actin Filament Polymerization Histone Acetyltransferase Complex Regulation Of Cell-matrix Adhesion Protein-lysine-acetyltransferase Activity Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein-containing Complex Assembly Regulation Of Actin Cytoskeleton Organization Neutrophil Activation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Focal Adhesion Assembly Binding Of Sperm To Zona Pellucida Histone Acetyltransferase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Acetylation