DNASE1 and ACTA2

Number of citations of the paper that reports this interaction (PMID 11707283)
2

Data Source:
HPRD (in vitro)

		DNASE1	ACTA2
Gene Name		deoxyribonuclease I	actin, alpha 2, smooth muscle, aorta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Envelope Extracellular Vesicular Exosome	Extracellular Space Cytoplasm Cytosol Actin Cytoskeleton Smooth Muscle Contractile Fiber Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Endodeoxyribonuclease Activity Deoxyribonuclease I Activity Protein Binding	ATP Binding Protein Kinase Binding
	Biological Process	DNA Catabolic Process, Endonucleolytic Apoptotic Process	Muscle Contraction Regulation Of Blood Pressure Response To Virus Vascular Smooth Muscle Contraction Glomerular Mesangial Cell Development
Pathways			Smooth Muscle Contraction
Drugs
Diseases
GWAS			Immunoglobulin A ( 20694011)
Protein-Protein Interactions		4 interactors: ACTA1 ACTA2 ACTB ACTG1	16 interactors: CCT4 CCT5 CFL1 CREBBP DNASE1 EP300 GC MINK1 MYL1 MYOC PCYT1B PRKCD SHBG SNTA1 TMSB4X YBX1
Entrez ID		1773	59
HPRD ID		00509	00031
Ensembl ID			ENSG00000107796
Uniprot IDs		P24855	D2JYH4 P62736
PDB IDs		4AWN
Enriched GO Terms of Interacting Partners?		Platelet Aggregation Cell Development Response To External Stimulus Retina Homeostasis Myofibril Assembly Adherens Junction Organization Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Actomyosin Structure Organization Striated Muscle Cell Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Muscle Cell Development Skeletal Muscle Fiber Adaptation Tissue Homeostasis Platelet Activation Cell Junction Assembly Cell Differentiation Cell-cell Junction Organization Muscle Contraction Striated Muscle Cell Differentiation Multicellular Organismal Homeostasis Muscle System Process Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Glomerular Mesangial Cell Development Movement Of Cell Or Subcellular Component System Development Mesangial Cell Development Skeletal Muscle Thin Filament Assembly Muscle Cell Differentiation Homotypic Cell-cell Adhesion Renal Interstitial Fibroblast Development Skeletal Myofibril Assembly Immune Response-regulating Cell Surface Receptor Signaling Pathway Skeletal Muscle Adaptation Axon Guidance Multicellular Organismal Development Blood Coagulation Anatomical Structure Development Hemostasis Cellular Component Assembly Vascular Smooth Muscle Contraction Immune Response-regulating Signaling Pathway Organelle Assembly Muscle Structure Development Single Organismal Cell-cell Adhesion Axonogenesis	N-terminal Peptidyl-lysine Acetylation Regulation Of Actin Filament-based Process N-terminal Protein Amino Acid Acetylation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Dephosphorylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Blood Coagulation N-terminal Protein Amino Acid Modification Hemostasis Negative Regulation Of Cytoskeleton Organization Regulation Of Cellular Response To Heat Platelet Activation Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Toxin Transport Binding Of Sperm To Zona Pellucida Positive Regulation Of Dephosphorylation Regulation Of Body Fluid Levels Sperm-egg Recognition Wound Healing Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of MAPK Cascade Regulation Of DNA-templated Transcription In Response To Stress Muscle System Process 'de Novo' Posttranslational Protein Folding Actin Filament-based Process Histone H2B Acetylation Positive Regulation Of Phospholipid Scramblase Activity Skeletal Muscle Hypertrophy Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process ERBB2-ERBB3 Signaling Pathway Regulation Of Vasoconstriction By Circulating Norepinephrine Primary Spermatocyte Growth 'de Novo' Protein Folding Developmental Process Cellular Response To Heat Cell Activation Cell-cell Recognition Termination Of Signal Transduction Response To Wounding Rhythmic Process Platelet Degranulation Negative Regulation Of Actin Filament Polymerization Regulation Of Cellular Component Size Positive Regulation Of Type I Interferon Production Positive Regulation Of Phospholipid Catabolic Process Glucosylceramide Catabolic Process ERBB2 Signaling Pathway
Tagcloud ?		chip crx dhs distinguish epigenetic essentially genome great h3k27me3 h3k4me2 hypersensitive identifying maps merged novo photoreceptor pol probability reflective retina retinal rod seq sets signature signatures striking unbiased widespread	attaining buffalo calves cirbp cryopreservation cryopreserved cyp11a1 d20s20 dairies dimethylsulfoxide dismutase2 dmso fbs fcc freezing germplasm homeobox leydig maturity pou pou5f1 protein3 rbm3 sod2 subfamily surviving testicular uncontrolled vim
Tagcloud (Difference) ?		chip crx dhs distinguish epigenetic essentially genome great h3k27me3 h3k4me2 hypersensitive identifying maps merged novo photoreceptor pol probability reflective retina retinal rod seq sets signature signatures striking unbiased widespread	attaining buffalo calves cirbp cryopreservation cryopreserved cyp11a1 d20s20 dairies dimethylsulfoxide dismutase2 dmso fbs fcc freezing germplasm homeobox leydig maturity pou pou5f1 protein3 rbm3 sod2 subfamily surviving testicular uncontrolled vim
Tagcloud (Intersection) ?