DNASE1

Description		deoxyribonuclease 1
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GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Envelope Cytoplasmic Vesicle Zymogen Granule Extracellular Exosome
	Molecular Function	DNA Binding Actin Binding Catalytic Activity Nuclease Activity Endonuclease Activity Deoxyribonuclease I Activity DNA Nuclease Activity Protein Binding Hydrolase Activity
	Biological Process	Neutrophil Activation Involved In Immune Response Regulation Of Acute Inflammatory Response DNA Catabolic Process Apoptotic Process Regulation Of Neutrophil Mediated Cytotoxicity
Pathways
Drugs
Diseases
GWAS		Body mass index ( 29273807) Monocyte percentage of white cells ( 32888494)
Novel Interacting Genes		1 novel interacting genes: TSC22D1
Interacting Genes		4 interacting genes: ACTA1 ACTA2 ACTB ACTG1
Entrez ID		1773
HPRD ID		00509
Ensembl ID		ENSG00000213918
Uniprot IDs		P24855
PDB IDs		4AWN
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Mesenchyme Migration Regulation Of Transepithelial Transport Dense Body Actin Filament Structural Constituent Of Postsynaptic Actin Cytoskeleton Morphogenesis Of A Polarized Epithelium Structural Constituent Of Cytoskeleton Blood Microparticle Postsynaptic Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Lamellipodium Postsynaptic Cytoskeleton Organization Regulation Of Synaptic Vesicle Endocytosis NuA4 Histone Acetyltransferase Complex Apical Junction Complex Regulation Of Synaptic Vesicle Recycling Maintenance Of Blood-brain Barrier Positive Regulation Of Macromolecule Biosynthetic Process Platelet Aggregation Positive Regulation Of Biosynthetic Process Homotypic Cell-cell Adhesion Protein Kinase Binding Positive Regulation Of Macromolecule Metabolic Process ATP Binding Filopodium Cytoskeleton Cell Body Extracellular Space Stress Fiber Positive Regulation Of Hepatic Stellate Cell Contraction Protein Localization To Cell Junction Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Positive Regulation Of Metabolic Process Schaffer Collateral - CA1 Synapse Hydrolase Activity Nucleotide Binding Cell-cell Junction Assembly Positive Regulation Of Hepatic Stellate Cell Migration Regulation Of Norepinephrine Uptake Axonogenesis Juxtaglomerular Apparatus Development Transporter Regulator Activity Extracellular Exosome Cell-cell Junction Organization Glomerular Mesangial Cell Development Smooth Muscle Contractile Fiber
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