KIAA1549 and ITSN2

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
HPRD (two hybrid)

		KIAA1549	ITSN2
Gene Name		KIAA1549	intersectin 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane	Cytoplasm Extracellular Vesicular Exosome
	Molecular Function		SH3/SH2 Adaptor Activity Rho Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding
	Biological Process		Endocytosis Positive Regulation Of Signal Transduction Positive Regulation Of Rho GTPase Activity
Pathways
Drugs
Diseases
GWAS			Working memory ( 21107309)
Protein-Protein Interactions		10 interactors: CADPS CDC73 DST GNE ITSN2 LGALS4 MBD5 MYO5B SOD2 ZBTB16	75 interactors: AGT AHDC1 AMPH ANKRD17 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DNM2 DST EPS15 EPS15L1 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREML GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LARP6 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RABEP1 RAD9A RBMX REPS1 RNF20 ROCK1 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1
Entrez ID		57670	50618
HPRD ID		13873	09193
Ensembl ID		ENSG00000122778	ENSG00000198399
Uniprot IDs		Q9HCM3	A6H8W8 Q9NZM3
PDB IDs			1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Fibroblast Proliferation Erythrophore Differentiation Age-dependent Response To Reactive Oxygen Species Vasodilation By Acetylcholine Involved In Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Myeloid Cell Differentiation Regulation Of Fibroblast Proliferation N-acetylglucosamine Biosynthetic Process Positive Regulation Of Growth Hormone Receptor Signaling Pathway Response To Silicon Dioxide Response To Magnetism Regulation Of Fat Cell Differentiation Catecholamine Secretion Regulation Of Growth Hormone Receptor Signaling Pathway Age-dependent Response To Oxidative Stress Positive Regulation Of NK T Cell Differentiation Detection Of Oxygen Negative Regulation Of Cell Proliferation Regulation Of Myeloid Cell Differentiation Male Germ-line Stem Cell Asymmetric Division Response To Selenium Ion Endosome Localization Negative Regulation Of Cell Differentiation Oxygen Homeostasis Cellular Response To Ethanol N-acetylneuraminate Metabolic Process Histone H2B Ubiquitination Hydrogen Peroxide Biosynthetic Process Synaptic Vesicle Priming Response To Isolation Stress	Vesicle-mediated Transport Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Cell Communication Signaling Cellular Response To Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cellular Component Assembly Signal Transduction Synaptic Vesicle Transport Enzyme Linked Receptor Protein Signaling Pathway Actin Filament-based Movement Cell-cell Signaling Response To Stimulus Establishment Of Vesicle Localization Cell Surface Receptor Signaling Pathway Vesicle Localization Organelle Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cellular Process Negative Regulation Of Membrane Tubulation Regulation Of Signaling Protein Complex Assembly Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Vesicle Organization Establishment Of Organelle Localization Positive Regulation Of Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Immune Response-regulating Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Cell Death Transport Apoptotic Process Cellular Localization Regulation Of Cell Death Positive Regulation Of Intracellular Signal Transduction Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Regulation Of Vesicle-mediated Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Establishment Of Localization In Cell Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway
Tagcloud ?		10q 3q26 6q23 7q34 9q astrocytoma chek2 dnt dysembryoplastic encompassed fam131b fibrillary ganglioglioma gliomas lggs mbs medulloblastomas neuroepithelial nf1 nf2 philadelphia pilocytic q10 qki refine sanger thr599dup tier v600e	abl1 adaptor clathrin colocalize crk domains enabled endocytosis fgr fyn hela interactors interface intersectin isoform isoforms itsn1 itsns mentioned paralogous pathologies phospholipase scaffolding sh2 sh3 tyrosines unable vertebrates
Tagcloud (Difference) ?		10q 3q26 6q23 7q34 9q astrocytoma chek2 dnt dysembryoplastic encompassed fam131b fibrillary ganglioglioma gliomas lggs mbs medulloblastomas neuroepithelial nf1 nf2 philadelphia pilocytic q10 qki refine sanger thr599dup tier v600e	abl1 adaptor clathrin colocalize crk domains enabled endocytosis fgr fyn hela interactors interface intersectin isoform isoforms itsn1 itsns mentioned paralogous pathologies phospholipase scaffolding sh2 sh3 tyrosines unable vertebrates
Tagcloud (Intersection) ?