KIAA1549 and CDC73

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		KIAA1549	CDC73
Gene Name		KIAA1549	cell division cycle 73
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane	Nucleus Nucleoplasm Cdc73/Paf1 Complex
	Molecular Function		RNA Polymerase II Core Binding Protein Binding
	Biological Process		Negative Regulation Of Transcription From RNA Polymerase II Promoter Endodermal Cell Fate Commitment Transcription, DNA-templated MRNA Polyadenylation Cell Cycle Negative Regulation Of Cell Proliferation Histone Monoubiquitination Wnt Signaling Pathway Stem Cell Maintenance Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of MRNA 3'-end Processing Protein Destabilization Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Hedgehog 'on' state formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Hedgehog Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS			Subcutaneous adipose tissue ( 22589738)
Protein-Protein Interactions		10 interactors: CADPS CDC73 DST GNE ITSN2 LGALS4 MBD5 MYO5B SOD2 ZBTB16	30 interactors: ALAS1 ANXA6 CCDC155 CEP70 CTNNB1 DDAH2 FAF1 FSD2 GC GOLGA2 HAP1 HIST1H1C HSF2BP HSPA4 ITFG1 KCNH2 KIAA1549 KIDINS220 MCM3AP MTUS2 PITHD1 RNF20 RNF40 TCEA1 TCF4 TFCP2 TOMM20 TSGA10 VPS37B WWC1
Entrez ID		57670	79577
HPRD ID		13873	09581
Ensembl ID		ENSG00000122778	ENSG00000134371
Uniprot IDs		Q9HCM3	Q6P1J9
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Fibroblast Proliferation Erythrophore Differentiation Age-dependent Response To Reactive Oxygen Species Vasodilation By Acetylcholine Involved In Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Myeloid Cell Differentiation Regulation Of Fibroblast Proliferation N-acetylglucosamine Biosynthetic Process Positive Regulation Of Growth Hormone Receptor Signaling Pathway Response To Silicon Dioxide Response To Magnetism Regulation Of Fat Cell Differentiation Catecholamine Secretion Regulation Of Growth Hormone Receptor Signaling Pathway Age-dependent Response To Oxidative Stress Positive Regulation Of NK T Cell Differentiation Detection Of Oxygen Negative Regulation Of Cell Proliferation Regulation Of Myeloid Cell Differentiation Male Germ-line Stem Cell Asymmetric Division Response To Selenium Ion Endosome Localization Negative Regulation Of Cell Differentiation Oxygen Homeostasis Cellular Response To Ethanol N-acetylneuraminate Metabolic Process Histone H2B Ubiquitination Hydrogen Peroxide Biosynthetic Process Synaptic Vesicle Priming Response To Isolation Stress	Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Histone H2B Ubiquitination Cellular Localization Positive Regulation Of Glycoprotein Biosynthetic Process Establishment Of Localization In Cell Genitalia Morphogenesis Positive Regulation Of Glycoprotein Metabolic Process Organelle Organization Histone Monoubiquitination Regulation Of Glycoprotein Biosynthetic Process Establishment Of Protein Localization To Organelle Protein Localization Chromosome Organization Histone Ubiquitination Protein Import Positive Regulation Of Epithelial To Mesenchymal Transition Cellular Process Cytoplasmic Transport Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Histone Methylation Intracellular Transport Positive Regulation Of Neurogenesis Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Organ Growth Organelle Localization Transcription-coupled Nucleotide-excision Repair Regulation Of Oligodendrocyte Differentiation Protein Targeting Protein Monoubiquitination Myoblast Differentiation Regulation Of Intracellular Transport Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Chromosome Localization To Nuclear Envelope Involved In Synapsis Negative Regulation Of Potassium Ion Export Regulation Of Myelination Positive Regulation Of Intracellular Signal Transduction Skin Morphogenesis Vesicle Localization Regulation Of Histone Methylation Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Signal Transduction Positive Regulation Of Cell Development Genitalia Development Regulation Of Intracellular Signal Transduction Skin Development Regulation Of Epithelial To Mesenchymal Transition Protein Localization To Organelle Protein Transmembrane Transport
Tagcloud ?		10q 3q26 6q23 7q34 9q astrocytoma chek2 dnt dysembryoplastic encompassed fam131b fibrillary ganglioglioma gliomas lggs mbs medulloblastomas neuroepithelial nf1 nf2 philadelphia pilocytic q10 qki refine sanger thr599dup tier v600e	1379delt affecting caucasian encoded fibroma hpt hyperparathyroidism hystologically instrumental jaw jt l460lfs mandible modelling moiety mtt ossifying parafibromin parathyroid partners proband pth relatives sanger sca silico terminus underlie vast
Tagcloud (Difference) ?		10q 3q26 6q23 7q34 9q astrocytoma chek2 dnt dysembryoplastic encompassed fam131b fibrillary ganglioglioma gliomas lggs mbs medulloblastomas neuroepithelial nf1 nf2 philadelphia pilocytic q10 qki refine thr599dup tier v600e	1379delt affecting caucasian encoded fibroma hpt hyperparathyroidism hystologically instrumental jaw jt l460lfs mandible modelling moiety mtt ossifying parafibromin parathyroid partners proband pth relatives sca silico terminus underlie vast
Tagcloud (Intersection) ?		sanger