KIAA1549 and MYO5B

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		KIAA1549	MYO5B
Description		KIAA1549	myosin VB
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane Photoreceptor Connecting Cilium Cell Projection	Cytoplasm Actin Cytoskeleton Membrane Myosin Complex Cytoplasmic Vesicle Membrane Protein-containing Complex Apical Cortex Recycling Endosome Extracellular Exosome
	Molecular Function	Protein Binding	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Small GTPase Binding Actin Filament Binding
	Biological Process		Renal Water Homeostasis Endocytosis Actin Filament Organization Protein Transport Vesicle-mediated Transport Endosomal Transport
Pathways		Signaling by BRAF and RAF1 fusions	Vasopressin regulates renal water homeostasis via Aquaporins
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549)	Apolipoprotein A1 levels ( 29084231 32203549) HDL cholesterol levels ( 32203549) Large HDL particle concentration ( 29084231) Longevity (100 years and older) ( 33948810) Mean diameter of HDL particles ( 29084231) Medium HDL particle concentration ( 29084231) Multiple sclerosis ( 31604244) Myopia ( 27182965) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231) Refractive error ( 32231278) Resistant hypertension ( 31545351) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Total cholesterol levels in HDL ( 29084231)
Interacting Genes		10 interacting genes: CADPS CDC73 DST GNE ITSN2 LGALS4 MBD5 MYO5B SOD2 ZBTB16	23 interacting genes: AMOTL2 ATOSB BNIP2 COIL CXCR2 EFHC2 FXR1 GMCL1 KIAA1549 MEI4 MEOX2 POLR1C RAB11A RAB11B RAB11FIP2 RAB25 SHANK3 SMAD3 SMARCA2 TCF4 TRIM3 TRIM54 ZNHIT1
Entrez ID		57670	4645
HPRD ID		13873	07582
Ensembl ID		ENSG00000122778	ENSG00000167306
Uniprot IDs		Q9HCM3	Q7Z7A5 Q9ULV0
PDB IDs			4J5M 4LNZ 4LWZ 4LX0
Enriched GO Terms of Interacting Partners?		H Zone Antibacterial Peptide Biosynthetic Process Multicellular Organismal-level Chemical Homeostasis Response To Magnetism Positive Regulation Of Hydrogen Peroxide Biosynthetic Process Response To Isolation Stress Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching Negative Regulation Of Membrane Hyperpolarization Regulation Of Fibroblast Proliferation Superoxide Dismutase Activity Acetylcholine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Fibroblast Proliferation Erythrophore Differentiation Response To Silicon Dioxide Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation Type 2 Angiotensin Receptor Binding Male Germ-line Stem Cell Asymmetric Division Negative Regulation Of Myeloid Cell Differentiation Neuronal Dense Core Vesicle Membrane Vesicle-mediated Transport In Synapse CMP-N-acetylneuraminate Metabolic Process N-acylmannosamine Kinase Activity N-acetylneuraminate Biosynthetic Process N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine 2-epimerase Activity CMP-N-acetylneuraminate Biosynthetic Process Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Growth Hormone Receptor Signaling Pathway Regulation Of Membrane Hyperpolarization Regulation Of Fat Cell Differentiation Detection Of Oxygen Response To L-ascorbic Acid Positive Regulation Of MRNA 3'-end Processing Hemidesmosome Assembly Galactoside Binding Response To Superoxide Regulation Of NK T Cell Differentiation Endodermal Cell Fate Commitment	Myosin V Binding Regulation Of Long-term Neuronal Synaptic Plasticity Recycling Endosome Amyloid-beta Clearance By Transcytosis Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cell Differentiation Germ Cell Development G Protein Activity Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cell Projection Exocytosis Transcytosis Regulation Of Endocytic Recycling Recycling Endosome Membrane Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Pigment Granule Localization Amyloid-beta Clearance Epithelial Cell Morphogenesis
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