RAC1 and PRKCD

Number of citations of the paper that reports this interaction (PMID 19356729)
11

Data Source:
HPRD (in vivo)

		RAC1	PRKCD
Gene Name		ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	protein kinase C, delta
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Phagocytic Cup Cytoplasm Trans-Golgi Network Cytosol Actin Filament Plasma Membrane Focal Adhesion Membrane Extrinsic Component Of Plasma Membrane Lamellipodium Ruffle Membrane Cytoplasmic Ribonucleoprotein Granule Melanosome Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Cell-cell Junction Nuclear Matrix Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding Rab GTPase Binding Enzyme Binding Protein Kinase Binding GTP-dependent Protein Binding Thioesterase Binding Rho GDP-dissociation Inhibitor Binding	Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-independent Protein Kinase C Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Enzyme Binding Insulin Receptor Substrate Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Auditory Receptor Cell Morphogenesis Mast Cell Chemotaxis Epithelial Cell Morphogenesis Movement Of Cell Or Subcellular Component Inflammatory Response Hyperosmotic Response Cell Adhesion Cell-matrix Adhesion G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Metabolic Process Cell Proliferation Response To Wounding Anatomical Structure Morphogenesis Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Cell-substrate Adhesion Viral Process Cerebral Cortex Radially Oriented Cell Migration Embryonic Olfactory Bulb Interneuron Precursor Migration Lamellipodium Assembly Actin Cytoskeleton Organization Actin Filament Polymerization Platelet Activation Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization T Cell Costimulation Ruffle Organization Negative Regulation Of Interleukin-23 Production Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Engulfment Of Apoptotic Cell Innate Immune Response Cell-cell Junction Organization Bone Resorption Positive Regulation Of DNA Replication Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Negative Regulation Of Receptor-mediated Endocytosis Anatomical Structure Arrangement Dendrite Morphogenesis Cell Motility Regulation Of Defense Response To Virus By Virus Positive Regulation Of Stress Fiber Assembly Localization Within Membrane Positive Regulation Of Focal Adhesion Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Respiratory Burst Semaphorin-plexin Signaling Pathway Dopaminergic Neuron Differentiation Protein Localization To Plasma Membrane Positive Regulation Of Neutrophil Chemotaxis Cochlea Morphogenesis Ruffle Assembly Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Protein Phosphorylation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Cycle Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Gene Expression Regulation Of Receptor Activity Immunoglobulin Mediated Immune Response Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Termination Of Signal Transduction Platelet Activation Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Binding Interleukin-10 Production Interleukin-12 Production Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Protein Dephosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis B Cell Proliferation Neutrophil Activation Defense Response To Bacterium Negative Regulation Of MAP Kinase Activity Innate Immune Response Negative Regulation Of Insulin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Negative Regulation Of Peptidyl-tyrosine Phosphorylation Protein Stabilization Negative Regulation Of Filopodium Assembly Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Platelet Aggregation Cellular Senescence Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Signaling by GPCR DCC mediated attractive signaling FCERI mediated MAPK activation Signaling by Wnt Nef and signal transduction Signaling by SCF-KIT DAP12 signaling EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Sema4D induced cell migration and growth-cone collapse DAP12 interactions Host Interactions of HIV factors CD28 co-stimulation The role of Nef in HIV-1 replication and disease pathogenesis Factors involved in megakaryocyte development and platelet production GPCR downstream signaling Signaling by VEGF Fc epsilon receptor (FCERI) signaling Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Platelet activation, signaling and aggregation PCP/CE pathway Adaptive Immune System Axon guidance Costimulation by the CD28 family HIV Infection Translocation of GLUT4 to the plasma membrane L1CAM interactions VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Inactivation of Cdc42 and Rac Ephrin signaling EPH-ephrin mediated repulsion of cells Activation of Rac VEGFR2 mediated vascular permeability Sema4D mediated inhibition of cell attachment and migration G alpha (12/13) signalling events Sema4D in semaphorin signaling Netrin-1 signaling Innate Immune System Signalling by NGF Signal transduction by L1 Cell death signalling via NRAGE, NRIF and NADE Semaphorin interactions p75 NTR receptor-mediated signalling beta-catenin independent WNT signaling CD28 dependent Vav1 pathway DSCAM interactions NRAGE signals death through JNK GPVI-mediated activation cascade Signaling by Robo receptor	Ca-dependent events Signaling by GPCR CaM pathway Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Effects of PIP2 hydrolysis Interferon gamma signaling DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK G alpha (z) signalling events Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF Calmodulin induced events Regulation of mRNA stability by proteins that bind AU-rich elements Apoptotic cleavage of cellular proteins DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Signaling by VEGF Calmodulin induced events Downstream signal transduction Signaling by EGFR in Cancer Platelet activation, signaling and aggregation G alpha (q) signalling events HuR stabilizes mRNA DAG and IP3 signaling VEGFA-VEGFR2 Pathway CaM pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Programmed Cell Death Innate Immune System Signalling by NGF PLC beta mediated events Interferon Signaling Apoptotic execution phase Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR PLC-gamma1 signalling
Drugs		Guanosine-5\'-Diphosphate
Diseases
GWAS			Bipolar disorder ( 21926972) Ulcerative colitis ( 23128233) Ventricular conduction ( 21076409)
Protein-Protein Interactions		144 interactors: ACTA1 ACTB AKT1 ARFIP2 ARHGAP1 ARHGAP15 ARHGAP17 ARHGAP27 ARHGAP31 ARHGAP32 ARHGAP33 ARHGAP44 ARHGDIA ARHGDIB ARHGDIG ARHGEF2 ARHGEF25 ARHGEF4 ARHGEF7 ARL2BP BAG6 BAIAP2 BCR BIRC2 BRINP1 CASP3 CASP7 CAV1 CDC23 CDC42 CDC42BPG CDC42SE1 CDC42SE2 CFAP36 CHN1 CHN2 CIT CNTNAP1 COG5 COX3 CSN2 CYBA CYBB CYFIP1 DEF6 DIAPH1 DIAPH3 DMPK DOCK1 DOCK2 DOCK8 DVL1 DVL2 EIF2AK2 FHOD1 FLNA FMNL1 GRN HACD3 HPS4 ICMT IFNGR1 IL1RAP IQGAP1 IQGAP2 KALRN KPNA4 KPNA6 KRT40 KTN1 LATS1 LTBP3 LTBP4 LZTS2 MAGI1 MAP3K10 MAP3K11 MAP3K4 MCF2L MCM3AP METAP2 MTNR1A MYD88 MYH9 NCF2 NCK1 NCKAP1 NEDD4 NME1 NOS2 NOXA1 OCRL OPHN1 PAK1 PAK2 PAK3 PAK7 PARD6A PARD6B PARD6G PARK2 PIAS3 PIK3R1 PIP4K2A PLD1 PLEKHG2 PLXNB1 PPP2R2B PRKCA PRKCD PRKCI PRMT6 PTK2 RALBP1 RAP1GDS1 RASGRF1 RCC2 RGL2 RPS6KB1 SET SFPQ SH3BP1 SH3RF1 SH3RF3 STAT1 STAT3 STAU1 SUMO2 SYNJ2 TBC1D3F TIAM1 TLR2 TNFRSF12A TRIO TUBA4A UNKL USH1C USP6 VAV1 VAV2 VAV3 VWF WAS WASF1	118 interactors: ACTA1 ACTA2 ACTB ADAM9 ADCY7 ADD1 ADD2 ADRA2A ADRB2 ADRBK1 AFAP1 AKT3 APP ART3 BDKRB2 C1QBP CD34 CDCP1 CHAT CNP CREBBP CYTH1 DAB2 DYNC1H1 EEF1A1 EGFR EIF2S1 ELAVL1 EP300 ESRRA FLI1 FSCN1 FYN GABRA1 GAP43 GNA12 GNA13 GNAZ GNB2L1 GRM5 GSK3A HABP4 HDAC5 HIST1H1A HIST1H1B HNRNPK HSP90AA1 HSPA4 IGF1R IKBKB IL6ST INSR IRS1 ITGA6 ITGB2 ITGB4 ITGB7 ITPR1 KCNJ1 KCNJ4 KLF5 LCK LMNB1 LMNB2 LYN MACF1 MAPK1 MAPK3 MAPT MBP MEP1B MS4A2 MUC1 NCF1 NCF4 NFE2L2 NUMB OPRD1 PAK1 PDP1 PDP2 PDPK1 PEBP1 PIK3CA PIK3CB PLCB1 PLD2 PLSCR1 PLSCR3 PPARA PPM1A PPP1CA PPP2CA PPP2R5C PRKCZ PRKDC PTK2B PTPN22 PTPN6 PTPRA RAC1 RAF1 RASGRP3 RIPK4 RUNX2 SDC4 SHC1 SRC STAT1 STAT3 TAGLN TIAM1 TNFRSF1A VCP VHL YWHAB YWHAG YWHAZ
Entrez ID		5879	5580
HPRD ID		03627	01501
Ensembl ID		ENSG00000136238	ENSG00000163932
Uniprot IDs		A4D2P0 A4D2P1 P63000	Q05655
PDB IDs		1E96 1FOE 1G4U 1HE1 1HH4 1I4D 1I4L 1I4T 1MH1 1RYF 1RYH 2FJU 2H7V 2NZ8 2P2L 2RMK 2VRW 2WKP 2WKQ 2WKR 2YIN 3B13 3BJI 3RYT 3SBD 3SBE 3SU8 3SUA 3TH5 4GZL 4GZM	1YRK 2YUU
Enriched GO Terms of Interacting Partners?		Regulation Of Catalytic Activity Intracellular Signal Transduction Regulation Of Signal Transduction Signal Transduction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Signaling Cell Communication Cellular Response To Stimulus Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Positive Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Response To Stimulus Regulation Of Small GTPase Mediated Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Rho GTPase Activity Regulation Of Cellular Process Positive Regulation Of Rho GTPase Activity Positive Regulation Of Ras GTPase Activity Regulation Of Ras GTPase Activity Regulation Of Rho Protein Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Rac GTPase Activity Regulation Of Ras Protein Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Apoptotic Process Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To External Stimulus Positive Regulation Of Cell Death Innate Immune Response Cellular Response To Growth Factor Stimulus Movement Of Cell Or Subcellular Component Response To Growth Factor Cell Projection Organization Cellular Response To Organic Substance Generation Of Neurons	Signaling Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Metabolic Process Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Peptide Cellular Response To Stimulus Cellular Response To Peptide Hormone Stimulus Defense Response Response To Stress Cellular Response To Organonitrogen Compound Response To Stimulus Platelet Activation Cellular Response To Hormone Stimulus Regulation Of Signal Transduction Immune System Process Positive Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Response To Peptide Response To Hormone Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of Phosphorus Metabolic Process Innate Immune Response Regulation Of Signaling Response To Peptide Hormone Response To Wounding Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Growth Factor Wound Healing Cell Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Hemostasis Positive Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Protein Modification Process Anatomical Structure Development Positive Regulation Of Protein Phosphorylation Cellular Response To Insulin Stimulus Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Fc Receptor Signaling Pathway Immune Response Response To Insulin
Tagcloud ?		3t3 activate bind chimeric cytoskeletal dispensable effector effectors interrelationship jnk jun lamellipodia lamellipodium mediate nh2 nih p65 pak ras rho rhoa ruffling srf stimulate surprisingly threonine transformation transforming tumorigenic	alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition
Tagcloud (Difference) ?		3t3 activate bind chimeric cytoskeletal dispensable effector effectors interrelationship jnk jun lamellipodia lamellipodium mediate nh2 nih p65 pak ras rho rhoa ruffling srf stimulate surprisingly threonine transformation transforming tumorigenic	alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition
Tagcloud (Intersection) ?