RAC1 and GRN

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RAC1	GRN
Gene Name		ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	granulin
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Phagocytic Cup Cytoplasm Trans-Golgi Network Cytosol Actin Filament Plasma Membrane Focal Adhesion Membrane Extrinsic Component Of Plasma Membrane Lamellipodium Ruffle Membrane Cytoplasmic Ribonucleoprotein Granule Melanosome Extracellular Vesicular Exosome	Extracellular Space Mitochondrion Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding Rab GTPase Binding Enzyme Binding Protein Kinase Binding GTP-dependent Protein Binding Thioesterase Binding Rho GDP-dissociation Inhibitor Binding	Cytokine Activity Protein Binding Growth Factor Activity Poly(A) RNA Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Auditory Receptor Cell Morphogenesis Mast Cell Chemotaxis Epithelial Cell Morphogenesis Movement Of Cell Or Subcellular Component Inflammatory Response Hyperosmotic Response Cell Adhesion Cell-matrix Adhesion G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Metabolic Process Cell Proliferation Response To Wounding Anatomical Structure Morphogenesis Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Cell-substrate Adhesion Viral Process Cerebral Cortex Radially Oriented Cell Migration Embryonic Olfactory Bulb Interneuron Precursor Migration Lamellipodium Assembly Actin Cytoskeleton Organization Actin Filament Polymerization Platelet Activation Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization T Cell Costimulation Ruffle Organization Negative Regulation Of Interleukin-23 Production Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Engulfment Of Apoptotic Cell Innate Immune Response Cell-cell Junction Organization Bone Resorption Positive Regulation Of DNA Replication Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Negative Regulation Of Receptor-mediated Endocytosis Anatomical Structure Arrangement Dendrite Morphogenesis Cell Motility Regulation Of Defense Response To Virus By Virus Positive Regulation Of Stress Fiber Assembly Localization Within Membrane Positive Regulation Of Focal Adhesion Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Respiratory Burst Semaphorin-plexin Signaling Pathway Dopaminergic Neuron Differentiation Protein Localization To Plasma Membrane Positive Regulation Of Neutrophil Chemotaxis Cochlea Morphogenesis Ruffle Assembly Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Blastocyst Hatching Signal Transduction Embryo Implantation Positive Regulation Of Epithelial Cell Proliferation
Pathways		Signaling by GPCR DCC mediated attractive signaling FCERI mediated MAPK activation Signaling by Wnt Nef and signal transduction Signaling by SCF-KIT DAP12 signaling EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Sema4D induced cell migration and growth-cone collapse DAP12 interactions Host Interactions of HIV factors CD28 co-stimulation The role of Nef in HIV-1 replication and disease pathogenesis Factors involved in megakaryocyte development and platelet production GPCR downstream signaling Signaling by VEGF Fc epsilon receptor (FCERI) signaling Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Platelet activation, signaling and aggregation PCP/CE pathway Adaptive Immune System Axon guidance Costimulation by the CD28 family HIV Infection Translocation of GLUT4 to the plasma membrane L1CAM interactions VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Inactivation of Cdc42 and Rac Ephrin signaling EPH-ephrin mediated repulsion of cells Activation of Rac VEGFR2 mediated vascular permeability Sema4D mediated inhibition of cell attachment and migration G alpha (12/13) signalling events Sema4D in semaphorin signaling Netrin-1 signaling Innate Immune System Signalling by NGF Signal transduction by L1 Cell death signalling via NRAGE, NRIF and NADE Semaphorin interactions p75 NTR receptor-mediated signalling beta-catenin independent WNT signaling CD28 dependent Vav1 pathway DSCAM interactions NRAGE signals death through JNK GPVI-mediated activation cascade Signaling by Robo receptor
Drugs		Guanosine-5\'-Diphosphate
Diseases
GWAS			Intracranial volume ( 22504418)
Protein-Protein Interactions		144 interactors: ACTA1 ACTB AKT1 ARFIP2 ARHGAP1 ARHGAP15 ARHGAP17 ARHGAP27 ARHGAP31 ARHGAP32 ARHGAP33 ARHGAP44 ARHGDIA ARHGDIB ARHGDIG ARHGEF2 ARHGEF25 ARHGEF4 ARHGEF7 ARL2BP BAG6 BAIAP2 BCR BIRC2 BRINP1 CASP3 CASP7 CAV1 CDC23 CDC42 CDC42BPG CDC42SE1 CDC42SE2 CFAP36 CHN1 CHN2 CIT CNTNAP1 COG5 COX3 CSN2 CYBA CYBB CYFIP1 DEF6 DIAPH1 DIAPH3 DMPK DOCK1 DOCK2 DOCK8 DVL1 DVL2 EIF2AK2 FHOD1 FLNA FMNL1 GRN HACD3 HPS4 ICMT IFNGR1 IL1RAP IQGAP1 IQGAP2 KALRN KPNA4 KPNA6 KRT40 KTN1 LATS1 LTBP3 LTBP4 LZTS2 MAGI1 MAP3K10 MAP3K11 MAP3K4 MCF2L MCM3AP METAP2 MTNR1A MYD88 MYH9 NCF2 NCK1 NCKAP1 NEDD4 NME1 NOS2 NOXA1 OCRL OPHN1 PAK1 PAK2 PAK3 PAK7 PARD6A PARD6B PARD6G PARK2 PIAS3 PIK3R1 PIP4K2A PLD1 PLEKHG2 PLXNB1 PPP2R2B PRKCA PRKCD PRKCI PRMT6 PTK2 RALBP1 RAP1GDS1 RASGRF1 RCC2 RGL2 RPS6KB1 SET SFPQ SH3BP1 SH3RF1 SH3RF3 STAT1 STAT3 STAU1 SUMO2 SYNJ2 TBC1D3F TIAM1 TLR2 TNFRSF12A TRIO TUBA4A UNKL USH1C USP6 VAV1 VAV2 VAV3 VWF WAS WASF1	37 interactors: ARFGAP1 ATN1 ATXN7 CACNA1A CCDC33 CCNG1 CCNT1 CDK9 CRKL CRY1 DLK1 DLX2 ELANE FAM131C FANCL FRAT1 GFI1B GLRX3 HK3 HOXA1 HSPG2 KRT18 KRTAP10-7 KRTAP26-1 NLK OTX1 PIK3R2 POT1 PRKAB2 RAC1 SGTA SLPI SMAD9 TAT TGM2 TOP3B YY1
Entrez ID		5879	2896
HPRD ID		03627	00733
Ensembl ID		ENSG00000136238	ENSG00000030582
Uniprot IDs		A4D2P0 A4D2P1 P63000	P28799
PDB IDs		1E96 1FOE 1G4U 1HE1 1HH4 1I4D 1I4L 1I4T 1MH1 1RYF 1RYH 2FJU 2H7V 2NZ8 2P2L 2RMK 2VRW 2WKP 2WKQ 2WKR 2YIN 3B13 3BJI 3RYT 3SBD 3SBE 3SU8 3SUA 3TH5 4GZL 4GZM	1G26 2JYE 2JYT 2JYU 2JYV
Enriched GO Terms of Interacting Partners?		Regulation Of Catalytic Activity Intracellular Signal Transduction Regulation Of Signal Transduction Signal Transduction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Signaling Cell Communication Cellular Response To Stimulus Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Positive Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Response To Stimulus Regulation Of Small GTPase Mediated Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Rho GTPase Activity Regulation Of Cellular Process Positive Regulation Of Rho GTPase Activity Positive Regulation Of Ras GTPase Activity Regulation Of Ras GTPase Activity Regulation Of Rho Protein Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Rac GTPase Activity Regulation Of Ras Protein Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Apoptotic Process Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To External Stimulus Positive Regulation Of Cell Death Innate Immune Response Cellular Response To Growth Factor Stimulus Movement Of Cell Or Subcellular Component Response To Growth Factor Cell Projection Organization Cellular Response To Organic Substance Generation Of Neurons	Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Central Nervous System Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Regulation Of Metabolic Process Brain Development Regulation Of Kinase Activity Head Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Cellular Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Pattern Specification Process RNA Biosynthetic Process Regulation Of Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Organ Morphogenesis Anatomical Structure Morphogenesis Biosynthetic Process Negative Regulation Of Biosynthetic Process Homeostatic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Positive Regulation Of Metabolic Process Embryonic Organ Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Embryonic Skeletal System Development Response To Light Stimulus Hindbrain Development Regulation Of Protein Metabolic Process Regulation Of Signaling Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Phosphorus Metabolic Process Pons Development Cell Surface Receptor Signaling Pathway Response To Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Regulation Of Signal Transduction Cellular Aromatic Compound Metabolic Process Central Nervous System Neuron Differentiation Anatomical Structure Development Positive Regulation Of Transcription, DNA-templated
Tagcloud ?		3t3 activate bind chimeric cytoskeletal dispensable effector effectors interrelationship jnk jun lamellipodia lamellipodium mediate nh2 nih p65 pak ras rho rhoa ruffling srf stimulate surprisingly threonine transformation transforming tumorigenic	arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin hair intersubspecific junctional jup keratin kinds krt1 linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously
Tagcloud (Difference) ?		3t3 activate bind chimeric cytoskeletal dispensable effector effectors interrelationship jnk jun lamellipodia lamellipodium mediate nh2 nih p65 pak ras rho rhoa ruffling srf stimulate surprisingly threonine transformation transforming tumorigenic	arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin hair intersubspecific junctional jup keratin kinds krt1 linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously
Tagcloud (Intersection) ?