RAC1 and KPNA4

Number of citations: 36 (PubMedID 20936779)
Data Source: BioGRID (two hybrid)

		RAC1	KPNA4
Name		Rac family small GTPase 1	karyopherin subunit alpha 4
Structure
GO Annotations	Cellular Component	Pericentriolar Material Phagocytic Cup Nucleus Cytoplasm Endoplasmic Reticulum Membrane Trans-Golgi Network Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Cell Cortex Membrane Lamellipodium Dendrite Secretory Granule Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Ruffle Membrane Cytoplasmic Ribonucleoprotein Granule Melanosome Presynaptic Membrane Cell Projection NADPH Oxidase Complex Synapse Postsynaptic Membrane Recycling Endosome Membrane Kinocilium Extracellular Exosome Postsynapse Glutamatergic Synapse Ficolin-1-rich Granule Membrane	Male Germ Cell Nucleus Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Nuclear Membrane NLS-dependent Protein Nuclear Import Complex
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Enzyme Binding Protein Kinase Binding GTP-dependent Protein Binding Thioesterase Binding Protein-containing Complex Binding Rho GDP-dissociation Inhibitor Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Neuron Migration Positive Regulation Of Protein Phosphorylation Auditory Receptor Cell Morphogenesis Sphingosine-1-phosphate Receptor Signaling Pathway Epithelial Cell Morphogenesis Endocytosis Phagocytosis, Engulfment Inflammatory Response Hyperosmotic Response Cytoskeleton Organization Actin Filament Organization Cell Adhesion Cell-matrix Adhesion Establishment Or Maintenance Of Cell Polarity Enzyme-linked Receptor Protein Signaling Pathway G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Axon Guidance Motor Neuron Axon Guidance Regulation Of Cell Shape Response To Wounding Anatomical Structure Morphogenesis Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Endothelial Cell Migration Regulation Of Fibroblast Migration Negative Regulation Of Fibroblast Migration Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell-substrate Adhesion Regulation Of Neuron Maturation Dendrite Development Cell Migration Rac Protein Signal Transduction Cerebral Cortex Radially Oriented Cell Migration Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Regulation Of Cell Morphogenesis Cell Projection Assembly Lamellipodium Assembly Actin Cytoskeleton Organization Actin Filament Polymerization Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Cortical Cytoskeleton Organization Forebrain Development Positive Regulation Of Microtubule Polymerization Ruffle Organization Response To Lipopolysaccharide Negative Regulation Of Interleukin-23 Production Regulation Of Actin Cytoskeleton Organization Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Superoxide Anion Generation Erythrocyte Enucleation Engulfment Of Apoptotic Cell Cell-cell Junction Organization Regulation Of Nitric Oxide Biosynthetic Process Respiratory Burst Regulation Of Receptor Signaling Pathway Via JAK-STAT Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Receptor-mediated Endocytosis Anatomical Structure Arrangement Neuron Projection Morphogenesis Dendrite Morphogenesis Cell Motility Homeostasis Of Number Of Cells Within A Tissue Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Localization Within Membrane Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Synaptic Transmission, GABAergic Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Respiratory Burst Cell Chemotaxis Positive Regulation Of Dendritic Spine Development Regulation Of Cell Adhesion Involved In Heart Morphogenesis Regulation Of ERK5 Cascade Semaphorin-plexin Signaling Pathway Dopaminergic Neuron Differentiation Protein Localization To Plasma Membrane Angiotensin-activated Signaling Pathway Involved In Heart Process Positive Regulation Of Neutrophil Chemotaxis Cochlea Morphogenesis Ruffle Assembly Regulation Of Postsynapse Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Endocytosis Regulation Of Neutrophil Migration Positive Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Interneuron Migration Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Ovarian Follicle Development Regulation Of Neuron Migration	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Gene Expression Dopamine Secretion Protein Transport Positive Regulation Of Hippo Signaling Response To Hydrogen Peroxide
Pathways		GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT Translocation of SLC2A4 (GLUT4) to the plasma membrane Nef and signal transduction NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling FCERI mediated MAPK activation CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PCP/CE pathway Sema4D mediated inhibition of cell attachment and migration DCC mediated attractive signaling DCC mediated attractive signaling Activation of RAC1 Inactivation of CDC42 and RAC1 VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases activate KTN1 RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins RHO GTPases Activate NADPH Oxidases MAPK6/MAPK4 signaling Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 RAC1 GTPase cycle NTRK2 activates RAC1 Activated NTRK2 signals through CDK5 Activation of RAC1 downstream of NMDARs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis WNT5:FZD7-mediated leishmania damping Azathioprine ADME Factors involved in megakaryocyte development and platelet production	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs		Dextromethorphan Azathioprine Guanosine-5'-Diphosphate	None
GWAS		Apolipoprotein A1 levels ( 32203549 ) Basal cell carcinoma ( 31174203 ) Body mass index ( 26426971 ) Coronary artery disease ( 29212778 ) Keratinocyte cancer (MTAG) ( 31174203 ) LDL cholesterol levels ( 32203549 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Red cell distribution width ( 27863252 )	Alanine aminotransferase levels ( 33547301 ) Alcohol use disorder (total score) ( 30336701 ) Aspartate aminotransferase levels ( 33547301 ) Attention deficit hyperactivity disorder ( 32279069 ) Bipolar disorder ( 31043756 ) Malaria ( 31844061 ) Myeloproliferative neoplasms ( 33057200 ) Pit-and-Fissure caries ( 24556642 ) Post bronchodilator FEV1 ( 26634245 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Smooth-surface caries ( 24556642 ) Total cholesterol levels ( 30275531 )
Interacting Genes		184 interacting genes: ACTA1 ACTB AGAP1 AGAP2 AKT1 ARAP1 ARAP2 ARFIP2 ARHGAP12 ARHGAP15 ARHGAP17 ARHGAP20 ARHGAP22 ARHGAP23 ARHGAP27 ARHGAP31 ARHGAP32 ARHGAP33 ARHGAP35 ARHGAP39 ARHGAP4 ARHGAP44 ARHGAP9 ARHGDIA ARHGDIB ARHGDIG ARHGEF10 ARHGEF2 ARHGEF25 ARHGEF26 ARHGEF4 ARHGEF7 ARL2BP BAG6 BAIAP2 BIRC2 BRINP1 CASP3 CASP7 CAV1 CDC23 CDC42BPG CDC42SE1 CDC42SE2 CEBPA CFAP36 CHN1 CHN2 CIT COG5 CORO1C CSN2 CYBA CYBB CYFIP1 DEF6 DIAPH1 DIAPH3 DMPK DNMBP DOCK1 DOCK2 DOCK3 DOCK7 DOCK8 DVL1 DVL2 EIF2AK2 ENAH FAM13A FAM13B FGD5 FHOD1 FLNA FMN2 FMNL1 GMIP GRIA2 GRN HACD3 HACE1 HDAC7 HPS4 ICMT IFNGR1 IL1RAP IQGAP1 IQGAP2 KPNA4 KPNA6 KRT40 KTN1 LATS1 LRP2 LTBP3 LTBP4 LZTS2 MAGI1 MAP3K10 MAP3K11 MAP3K4 MCF2 MCF2L MCM3AP MDFI METAP2 MT-CO3 MTNR1A MYD88 MYH9 NCF2 NCK1 NCKAP1 NEDD4 NME1 NOS2 NOXA1 NR2C2 OCRL OPHN1 PAK1 PAK2 PAK3 PAK5 PARD6A PARD6B PARD6G PIAS3 PIK3R1 PIP4K2A PLD1 PLEKHG1 PLEKHG2 PLEKHG6 PLXNA1 PLXNB1 PPP2R2B PREX1 PREX2 PRKCA PRKCD PRKCI PRKN PRMT6 PTK2 RACGAP1 RALBP1 RAP1GDS1 RASGRF1 RASGRF2 RCC2 RGL2 RPS6KB1 SET SFPQ SH3BP1 SH3RF1 SH3RF3 SNCA SNX31 SRGAP1 SRGAP3 STAT1 STAT3 STAU1 SYDE2 SYNJ2 TBC1D3F TIAM1 TLR2 TNFRSF12A TRIM72 TRIO TUBA4A UBC UNKL USH1C USP6 VAV1 VAV2 VAV3 VWF WAS WASF1	49 interacting genes: ADNP AFF2 APP CDKN1B CFAP298 CSE1L CSNK2A1 CTDSPL2 CUL4B DMTF1 DYRK1A EXO1 FAM50B GTF2IRD1 HIF1A HJURP HNRNPC HSD3B7 KAT5 KDR MAT2B MEF2C MORC3 MRTFB MTA1 NCBP3 NCOR2 NFE2L2 NKX2-5 NRIP1 NTRK3 OGT PLAA PLEKHG4B RAC1 RANBP3 RECQL RNF38 RYBP SCAND3 SPRTN SQSTM1 TGM2 TPX2 WT1 ZFTRAF1 ZMIZ2 ZNF532 ZRANB3
Entrez ID		5879	3840
HPRD ID		03627	04275
Ensembl ID		ENSG00000136238	ENSG00000186432
Uniprot IDs		A4D2P0 A4D2P1 P63000	O00629
PDB IDs		1E96 1FOE 1G4U 1HE1 1HH4 1I4D 1I4L 1I4T 1MH1 1RYF 1RYH 2FJU 2H7V 2NZ8 2P2L 2RMK 2VRW 2WKP 2WKQ 2WKR 2YIN 3B13 3BJI 3RYT 3SBD 3SBE 3SU8 3SUA 3TH5 4GZL 4GZM 4YON 5FI0 5HZH 5N6O 5O33 5QQD 5QQE 5QQF 5QQG 5QQH 5QQI 5QQJ 5QQK 5QQL 5QQM 5QQN 5QU9 6AGP 6BC1 6TGC 6X1G 7AJK 7DPA 7SJ4 7USD 7USE 8I5V 8I5W 8Q0N 8WEJ 8ZJ2 8ZJI 8ZJJ 8ZJK 8ZJL 8ZJM	4UAE 5TBK 5XZX 6BVV 6BVZ 6BW9 6BWA 6BWB 6WX8 7JJL 7LF4 7LFC 7RFY 7RG5 8FUB 8FZM 8HKW
GO Terms Enriched among Interactors		Regulation Of Small GTPase Mediated Signal Transduction GTPase Activator Activity Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Cytosol Regulation Of Cell Communication Regulation Of Signaling Small GTPase Binding Intracellular Signaling Cassette Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Signal Transduction Guanyl-nucleotide Exchange Factor Activity Regulation Of Cellular Component Organization Cytoplasm Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Regulation Of Actin Cytoskeleton Organization Plasma Membrane Regulation Of Organelle Organization Cell Cortex Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Regulation Of Cell Projection Organization Glutamatergic Synapse Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Rho Protein Signal Transduction Actin Filament Organization Cell Projection Organization Regulation Of Anatomical Structure Morphogenesis Supramolecular Fiber Organization Regulation Of Developmental Process Postsynapse Regulation Of Synapse Organization SH3 Domain Binding Regulation Of Cell Morphogenesis Positive Regulation Of Signaling Cell Projection Positive Regulation Of Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Cell Communication Ruffle Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Lamellipodium Regulation Of Cell Shape Cell Migration Regulation Of Biological Quality Lamellipodium Organization	Nucleus Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Rhythmic Process Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Positive Regulation Of Developmental Process Chromatin Organization Regulation Of Developmental Growth Apoptotic Process Regulation Of MiRNA Metabolic Process Regulation Of Cellular Component Organization Regulation Of Growth Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Chromatin Regulation Of Synapse Assembly Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Programmed Cell Death Cell Death Regulation Of Cell Junction Assembly DNA Binding DNA Repair Epithelial Tube Morphogenesis Regulation Of Synapse Organization Positive Regulation Of Catabolic Process