FGD1 and CTTN

Number of citations of the paper that reports this interaction (PMID 12913069)
25

Data Source:
HPRD (in vitro)

		FGD1	CTTN
Gene Name		FYVE, RhoGEF and PH domain containing 1	cortactin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Lamellipodium	Ruffle Cytoplasm Cytoskeleton Actin Filament Coated Pit Focal Adhesion Cell Cortex Voltage-gated Potassium Channel Complex Lamellipodium Growth Cone Cortical Cytoskeleton Dendritic Spine Extracellular Vesicular Exosome Mitotic Spindle Midzone
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Small GTPase Binding Metal Ion Binding	Protein Binding
	Biological Process	Cytoskeleton Organization Signal Transduction Small GTPase Mediated Signal Transduction Multicellular Organismal Development Regulation Of Cell Shape Organ Morphogenesis Actin Cytoskeleton Organization Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Regulation Of Cdc42 GTPase Activity Positive Regulation Of GTPase Activity Filopodium Assembly Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Intracellular Protein Transport Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Actin Filament Polymerization Regulation Of Axon Extension Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Dendritic Spine Maintenance Lamellipodium Organization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: AOC1 CDC42 CTTN ELMO1	36 interactors: ACD ACTA1 ACTG1 ACTR2 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 CASP3 CD2AP CHD3 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 FER FGD1 GRB2 HAX1 HDAC6 HIP1R KCNA2 MET MYLK SDC3 SHANK2 SIRT1 SPRR2A SRC SYK TINF2 TJP1 TNK2 WASL WIPF1
Entrez ID		2245	2017
HPRD ID		02373	01268
Ensembl ID		ENSG00000102302	ENSG00000085733
Uniprot IDs		P98174	Q14247 Q53HG7
PDB IDs			1X69 2D1X
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Actin Filament-based Process Adherens Junction Organization Endocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Copper Ion Starvation Cellular Response To Azide Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Hair Follicle Cell Proliferation Cytoskeleton Organization Cell-cell Junction Organization Actin Filament Branching Submandibular Salivary Gland Formation Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Phagocytosis Fc Receptor Signaling Pathway Cellular Response To Heparin Immune Response-activating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Cell Projection Assembly Response To Heparin Establishment Of Golgi Localization Cellular Response To Copper Ion Actin Filament Organization Movement Of Cell Or Subcellular Component Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Metalloenzyme Activity Regulation Of Protein Complex Assembly Dendritic Spine Maintenance Neuron Fate Determination Epithelial-mesenchymal Cell Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Histamine Regulation Of Protein Heterodimerization Activity Keratinocyte Development Substrate-dependent Cell Migration, Cell Extension Regulation Of Synapse Structural Plasticity Response To Histamine Transport Positive Regulation Of Pseudopodium Assembly Nuclear Migration Cardiac Conduction System Development Phagocytosis, Engulfment Immune Response-regulating Signaling Pathway Regulation Of Cell Morphogenesis Golgi Localization Regulation Of Cell Projection Organization	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Endocytosis Fc Receptor Signaling Pathway Cellular Response To Stimulus Cellular Component Assembly Regulation Of Cellular Component Organization Actin Cytoskeleton Organization Actin Filament-based Process Anatomical Structure Development Response To External Stimulus Developmental Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Phagocytosis Cell Communication Positive Regulation Of Organelle Organization Multicellular Organismal Development Immune Response-activating Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Organelle Organization Movement Of Cell Or Subcellular Component Chemotaxis Immune Response-regulating Signaling Pathway System Development Signaling Cytoskeleton Organization Signal Transduction Positive Regulation Of Immune System Process Response To Stimulus Cell Projection Organization Cell Morphogenesis Involved In Differentiation Axon Guidance Locomotion Innate Immune Response Positive Regulation Of Protein Complex Assembly Regulation Of Immune System Process Cell Morphogenesis Actin Filament Organization Positive Regulation Of Immune Response Neuron Projection Morphogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Immune Response Peptidyl-tyrosine Autophosphorylation Regulation Of Protein Complex Assembly Positive Regulation Of Cytoskeleton Organization
Tagcloud ?		apo bend butterfly catalysis charged citrate coenzyme competitive crystallography facilitates flavin g6p helps identifies isoalloxazine microorganisms moiety mycobacteria nitroimidazopyran occupies packs persistence phosphate pocket prodrug replicating resolutions shared	applicability csmd1 delineate emphasized fadd fgf4 fhit floor gains gata4 imbalances individualized losses mandatory mccc1 mlpa mouth mtus1 multiplex p428 panel probe probemix propensity ptk2 rarb relapses tier wisp1
Tagcloud (Difference) ?		apo bend butterfly catalysis charged citrate coenzyme competitive crystallography facilitates flavin g6p helps identifies isoalloxazine microorganisms moiety mycobacteria nitroimidazopyran occupies packs persistence phosphate pocket prodrug replicating resolutions shared	applicability csmd1 delineate emphasized fadd fgf4 fhit floor gains gata4 imbalances individualized losses mandatory mccc1 mlpa mouth mtus1 multiplex p428 panel probe probemix propensity ptk2 rarb relapses tier wisp1
Tagcloud (Intersection) ?