FGD1 and AOC1

Number of citations: 0 (PubMedID 12913069)
Data Source: HPRD (in vitro, in vivo)

		FGD1	AOC1
Name		FYVE, RhoGEF and PH domain containing 1	amine oxidase copper containing 1
Structure		No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Lamellipodium Cell Projection	Extracellular Region Extracellular Space Peroxisome Plasma Membrane Bicellular Tight Junction Membrane Specific Granule Lumen Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Zinc Ion Binding Small GTPase Binding Metal Ion Binding	Copper Ion Binding Calcium Ion Binding Protein Binding Primary Methylamine Oxidase Activity Heparin Binding Oxidoreductase Activity Protein Homodimerization Activity Metal Ion Binding Quinone Binding Putrescine Oxidase Activity Diamine Oxidase Activity Histamine Oxidase Activity
	Biological Process	Cytoskeleton Organization Signal Transduction Regulation Of Cell Shape Animal Organ Morphogenesis Actin Cytoskeleton Organization Regulation Of GTPase Activity Filopodium Assembly Regulation Of Small GTPase Mediated Signal Transduction	Amine Metabolic Process Putrescine Metabolic Process
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle	Phase I - Functionalization of compounds Neutrophil degranulation
Drugs		None	Amiloride Calcium Diminazene Pimagedine
Diseases		Aarskog-Scott syndrome; Faciogenital dysplasia	None
GWAS		Prostate cancer ( 31562322 )	Anthropometric traits (multi-trait analysis) ( 30166351 ) Apolipoprotein A1 levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Blood protein levels ( 30072576 ) Carpal tunnel syndrome ( 30833571 ) Eyebrow thickness ( 26926045 ) HDL cholesterol ( 30275531 ) HDL cholesterol levels ( 32203549 ) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Multisite chronic pain ( 33830993 ) Serum alkaline phosphatase levels ( 33547301 ) Serum metabolite concentrations in chronic kidney disease ( 29545352 ) Triglyceride levels ( 32203549 ) Triglycerides ( 30275531 ) Type 2 diabetes ( 30297969 ) Urinary metabolite levels in chronic kidney disease ( 31959995 )
Interacting Genes		5 interacting genes: AOC1 CDC42 CTTN ELMO1 SH3RF1	14 interacting genes: CYB561A3 DAO DAZAP2 DNM2 FGD1 FOXH1 KLHL20 KRTAP8-1 NTAQ1 POGZ RBPMS2 TIAL1 TLX3 ZC3H10
Entrez ID		2245	26
HPRD ID		02373	00088
Ensembl ID		ENSG00000102302	ENSG00000002726
Uniprot IDs		P98174	P19801
PDB IDs		Not available	3HI7 3HIG 3HII 3K5T 3MPH
GO Terms Enriched among Interactors		Neuron Projection Organization Dendritic Spine Organization Postsynapse Organization Phagocytosis, Engulfment Membrane Invagination Cell Motility Postsynapse Actin Cytoskeleton Organization Actin Filament-based Process Endocytosis Diamine Oxidase Activity Putrescine Oxidase Activity Histamine Oxidase Activity Glutamatergic Synapse Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Import Into Cell GBD Domain Binding Storage Vacuole Regulation Of Postsynapse Organization Endothelin Receptor Signaling Pathway Involved In Heart Process Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Apolipoprotein A-I Receptor Binding Intracellular Signaling Cassette Neuropilin Signaling Pathway Positive Regulation Of Cytoskeleton Organization Lamellipodium Quinone Binding Primary Methylamine Oxidase Activity Putrescine Metabolic Process Leading Edge Membrane Regulation Of Cell Projection Assembly Thioesterase Binding Cell Projection Morphogenesis Positive Regulation Of Pinocytosis Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Actin Filament Organization Vesicle-mediated Transport Actin Filament Organization Cytoskeleton Organization Small GTPase-mediated Signal Transduction Cell Junction Assembly Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Neuron Projection Morphogenesis Golgi Transport Complex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Profilin Binding	Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Cytoplasmic Stress Granule D-serine Catabolic Process Glycine Oxidase Activity D-amino-acid Dehydrogenase Activity D-alanine Catabolic Process Type II Interferon Binding Protein-N-terminal Glutamine Amidohydrolase Activity D-serine Metabolic Process D-amino Acid Catabolic Process D-amino-acid Oxidase Activity Negative Regulation Of Membrane Tubulation Vesicle Scission Protein K33-linked Ubiquitination Protein-N-terminal Asparagine Amidohydrolase Activity