FGD1 and ELMO1

Number of citations: 0 (PubMedID 12134158)
Data Source: HPRD (in vivo)

		FGD1	ELMO1
Name		FYVE, RhoGEF and PH domain containing 1	engulfment and cell motility 1
Structure		No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Lamellipodium Cell Projection	Cytoplasm Cytosol Plasma Membrane Membrane Guanyl-nucleotide Exchange Factor Complex Postsynapse Glutamatergic Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Zinc Ion Binding Small GTPase Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding
	Biological Process	Cytoskeleton Organization Signal Transduction Regulation Of Cell Shape Animal Organ Morphogenesis Actin Cytoskeleton Organization Regulation Of GTPase Activity Filopodium Assembly Regulation Of Small GTPase Mediated Signal Transduction	Phagocytosis Phagocytosis, Engulfment Apoptotic Process Actin Filament Organization Rac Protein Signal Transduction Actin Filament-based Process Actin Cytoskeleton Organization Cell Motility Regulation Of Postsynapse Assembly
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle	Nef and signal transduction Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis
Diseases		Aarskog-Scott syndrome; Faciogenital dysplasia	None
GWAS		Prostate cancer ( 31562322 )	Alzheimer's disease (cognitive decline) ( 23535033 ) Anticoagulant levels ( 22216198 ) Autoimmune thyroid disease ( 32581359 ) Autoimmune traits (pleiotropy) ( 30572963 ) Body fat mass ( 28552196 ) Breast size ( 22747683 ) Celiac disease ( 25920553 30572963 22057235 20190752 ) Celiac disease and Rheumatoid arthritis ( 26546613 ) Celiac disease or Rheumatoid arthritis ( 21383967 ) Cerebrospinal fluid AB1-42 levels ( 28247064 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Height ( 31562340 ) Inflammatory skin disease ( 25574825 ) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Mean platelet volume ( 32888494 27863252 ) Medication use (thyroid preparations) ( 31015401 ) Multiple sclerosis ( 31604244 24076602 ) Neutrophil percentage of granulocytes ( 27863252 ) Neutrophil percentage of white cells ( 32888494 ) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243 ) Platelet count ( 32888494 ) Platelet distribution width ( 27863252 32888494 ) PR interval ( 32439900 ) Primary biliary cirrhosis ( 22961000 ) Psoriasis ( 25574825 23143594 ) Psoriasis vulgaris ( 26626624 ) QT interval ( 20031603 ) Response to treatment for acute lymphoblastic leukemia ( 19176441 ) Rheumatoid arthritis ( 23143596 ) Sum eosinophil basophil counts ( 27863252 ) Systemic sclerosis ( 30572963 ) Trunk fat mass ( 28552196 ) Type 2 diabetes nephropathy ( 17653210 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		5 interacting genes: AOC1 CDC42 CTTN ELMO1 SH3RF1	11 interacting genes: ADGRB1 ADGRB3 APBB1 CEBPA DOCK1 DOCK2 FGD1 HCK RHOG TRIM54 ZNF398
Entrez ID		2245	9844
HPRD ID		02373	12102
Ensembl ID		ENSG00000102302	ENSG00000155849
Uniprot IDs		P98174	A4D1X5 Q92556
PDB IDs		Not available	2RQR 2VSZ 3A98 6JPP 6TGB 6TGC 7DPA 7Y4A 8JHK 8XM7 8ZJ2 8ZJI 8ZJJ 8ZJK 8ZJL 8ZJM
GO Terms Enriched among Interactors		Neuron Projection Organization Dendritic Spine Organization Postsynapse Organization Phagocytosis, Engulfment Membrane Invagination Cell Motility Postsynapse Actin Cytoskeleton Organization Actin Filament-based Process Endocytosis Diamine Oxidase Activity Putrescine Oxidase Activity Histamine Oxidase Activity Glutamatergic Synapse Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Import Into Cell GBD Domain Binding Storage Vacuole Regulation Of Postsynapse Organization Endothelin Receptor Signaling Pathway Involved In Heart Process Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Apolipoprotein A-I Receptor Binding Intracellular Signaling Cassette Neuropilin Signaling Pathway Positive Regulation Of Cytoskeleton Organization Lamellipodium Quinone Binding Primary Methylamine Oxidase Activity Putrescine Metabolic Process Leading Edge Membrane Regulation Of Cell Projection Assembly Thioesterase Binding Cell Projection Morphogenesis Positive Regulation Of Pinocytosis Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Actin Filament Organization Vesicle-mediated Transport Actin Filament Organization Cytoskeleton Organization Small GTPase-mediated Signal Transduction Cell Junction Assembly Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Neuron Projection Morphogenesis Golgi Transport Complex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Profilin Binding	Myoblast Fusion Cell-cell Fusion Syncytium Formation Syncytium Formation By Plasma Membrane Fusion Regulation Of Synapse Assembly Signal Transduction Regulation Of Cell Junction Assembly Regulation Of Cellular Component Organization Regulation Of Synapse Organization Phagocytosis Regulation Of Cell Shape Regulation Of Anatomical Structure Morphogenesis Endocytosis Phagocytosis, Engulfment Guanyl-nucleotide Exchange Factor Activity Positive Regulation Of Cellular Component Organization Regulation Of Postsynapse Assembly Postsynapse Membrane Invagination Regulation Of Cell Morphogenesis Import Into Cell Developmental Process GTPase Activator Activity Small GTPase-mediated Signal Transduction Cell Projection Positive Regulation Of Synapse Assembly RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Small GTPase Binding Actin Cytoskeleton Organization Cytoskeleton Response To Vitamin B2 C/EBP Complex Plasma Membrane Actin Filament-based Process Intracellular Signaling Cassette Cell Migration Regulation Of Developmental Process CHOP-C/EBP Complex Integrin-mediated Signaling Pathway Membrane Raft Polarization Regulation Of Phagocytosis Myeloid Dendritic Cell Activation Involved In Immune Response Leukocyte Migration Involved In Immune Response Positive Regulation Of Cell Junction Assembly Focal Adhesion White Fat Cell Proliferation Respiratory Burst After Phagocytosis Cell Recognition Regulation Of GTPase Activity Intracellular Signal Transduction