FGD1

Name	FYVE, RhoGEF and PH domain containing 1
Structure	No pdb structure
Interactors	5 interactors: AOC1 CDC42 CTTN ELMO1 SH3RF1
GO Annotations	Cellular Component	Ruffle Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Lamellipodium Cell Projection
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Zinc Ion Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Cytoskeleton Organization Signal Transduction Regulation Of Cell Shape Animal Organ Morphogenesis Actin Cytoskeleton Organization Regulation Of GTPase Activity Filopodium Assembly Regulation Of Small GTPase Mediated Signal Transduction
Pathways	NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle
Diseases	Aarskog-Scott syndrome; Faciogenital dysplasia
GWAS	Prostate cancer ( 31562322 )
Entrez ID	2245
HPRD ID	02373
Ensembl ID	ENSG00000102302
Uniprot IDs	P98174
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Neuron Projection Organization Dendritic Spine Organization Postsynapse Organization Phagocytosis, Engulfment Membrane Invagination Cell Motility Postsynapse Actin Cytoskeleton Organization Actin Filament-based Process Endocytosis Diamine Oxidase Activity Putrescine Oxidase Activity Histamine Oxidase Activity Glutamatergic Synapse Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Import Into Cell GBD Domain Binding Storage Vacuole Regulation Of Postsynapse Organization Endothelin Receptor Signaling Pathway Involved In Heart Process Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Apolipoprotein A-I Receptor Binding Intracellular Signaling Cassette Neuropilin Signaling Pathway Positive Regulation Of Cytoskeleton Organization Lamellipodium Quinone Binding Primary Methylamine Oxidase Activity Putrescine Metabolic Process Leading Edge Membrane Regulation Of Cell Projection Assembly Thioesterase Binding Cell Projection Morphogenesis Positive Regulation Of Pinocytosis Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Actin Filament Organization Vesicle-mediated Transport Actin Filament Organization Cytoskeleton Organization Small GTPase-mediated Signal Transduction Cell Junction Assembly Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Neuron Projection Morphogenesis Golgi Transport Complex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Profilin Binding