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FGD1
Description
FYVE, RhoGEF and PH domain containing 1
Image
No pdb structure
GO Annotations
Cellular Component
Ruffle
Cytoplasm
Golgi Apparatus
Cytosol
Cytoskeleton
Plasma Membrane
Lamellipodium
Cell Projection
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
Zinc Ion Binding
Small GTPase Binding
Metal Ion Binding
Biological Process
Cytoskeleton Organization
Signal Transduction
Regulation Of Cell Shape
Animal Organ Morphogenesis
Actin Cytoskeleton Organization
Regulation Of GTPase Activity
Filopodium Assembly
Regulation Of Small GTPase Mediated Signal Transduction
Pathways
NRAGE signals death through JNK
G alpha (12/13) signalling events
CDC42 GTPase cycle
Drugs
Diseases
Aarskog-Scott syndrome; Faciogenital dysplasia
GWAS
Prostate cancer (
31562322
)
Interacting Genes
5 interacting genes:
AOC1
CDC42
CTTN
ELMO1
SH3RF1
Entrez ID
2245
HPRD ID
02373
Ensembl ID
ENSG00000102302
Uniprot IDs
P98174
PDB IDs
Enriched GO Terms of Interacting Partners
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Neuron Projection Organization
Dendritic Spine Organization
Postsynapse Organization
Phagocytosis, Engulfment
Membrane Invagination
Cell Motility
Postsynapse
Actin Cytoskeleton Organization
Actin Filament-based Process
Endocytosis
Diamine Oxidase Activity
Putrescine Oxidase Activity
Histamine Oxidase Activity
Glutamatergic Synapse
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Import Into Cell
GBD Domain Binding
Storage Vacuole
Regulation Of Postsynapse Organization
Endothelin Receptor Signaling Pathway Involved In Heart Process
Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Supramolecular Fiber Organization
Apolipoprotein A-I Receptor Binding
Intracellular Signaling Cassette
Neuropilin Signaling Pathway
Positive Regulation Of Cytoskeleton Organization
Lamellipodium
Quinone Binding
Primary Methylamine Oxidase Activity
Putrescine Metabolic Process
Leading Edge Membrane
Regulation Of Cell Projection Assembly
Thioesterase Binding
Cell Projection Morphogenesis
Positive Regulation Of Pinocytosis
Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
G Protein-coupled Receptor Signaling Pathway Involved In Heart Process
Regulation Of Actin Filament Organization
Vesicle-mediated Transport
Actin Filament Organization
Cytoskeleton Organization
Small GTPase-mediated Signal Transduction
Cell Junction Assembly
Neuron Fate Determination
Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis
Establishment Of Golgi Localization
Neuron Projection Morphogenesis
Golgi Transport Complex
Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Profilin Binding
Tagcloud
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