LTB4R2 and PER1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		LTB4R2	PER1
Description		leukotriene B4 receptor 2	period circadian regulator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Leukotriene B4 Receptor Activity G Protein-coupled Receptor Activity Leukotriene Receptor Activity G Protein-coupled Peptide Receptor Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Protein Binding Kinase Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding E-box Binding DNA-binding Transcription Factor Binding
	Biological Process	Chemotaxis Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Neuropeptide Signaling Pathway Keratinocyte Migration Leukotriene Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Sodium Ion Transport Chromatin Remodeling Circadian Rhythm Entrainment Of Circadian Clock Post-transcriptional Regulation Of Gene Expression Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Regulation Of Circadian Rhythm Negative Regulation Of Canonical NF-kappaB Signal Transduction Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Rhythmic Process Response To CAMP Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of P38MAPK Cascade Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Pathways		Leukotriene receptors G alpha (q) signalling events	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins Degradation of CRY and PER proteins
Drugs		Amelubant Leukotriene B4
Diseases
GWAS		Anorectal malformation ( 31136621) Height ( 28552196)	HDL cholesterol levels ( 32203549) High light scatter reticulocyte percentage of red cells ( 32888494)
Interacting Genes		46 interacting genes: AKT1 AP2M1 CANX CEBPZ CERS1 CHPT1 CNOT10 CRELD2 CSNK2B CTSA DDOST FOLR1 GJC2 GLOD4 GPR146 GPR37 HLA-A IL17RD IMP4 LAMP5 MDH1 MGLL MYO1E OBSL1 P4HTM PER1 PIGM PKD1 RPN2 SCARB1 SEC13 SGCB SLC2A1 STMN3 SV2A SYNGR2 TMED1 TMEM94 TMUB2 TSPAN3 TSPAN4 TSPAN7 TTC9B VPS25 WFS1 YIF1B	19 interacting genes: CCDC57 CRY1 CRY2 CSNK1D CSNK1E CSNK1G2 CSNK2B DELEC1 GPRASP1 HIF1A LTB4R2 PER2 PER3 PNMA1 RBPMS RIPOR2 TIMELESS TNS2 TRIP6
Entrez ID		56413	5187
HPRD ID		16153	03774
Ensembl ID		ENSG00000213906	ENSG00000179094
Uniprot IDs		B4E292 Q9NPC1	O15534
PDB IDs
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Extracellular Exosome Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vesicle Oligosaccharyltransferase Complex B	Regulation Of Circadian Rhythm Circadian Regulation Of Gene Expression Circadian Rhythm Rhythmic Process Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Kinase Binding Negative Regulation Of Circadian Rhythm Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Response To Activity Cry-Per Complex Negative Regulation Of Glucocorticoid Secretion Nuclear Receptor Binding Response To Blue Light Response To Light Stimulus Transcription Corepressor Binding Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Photoreceptor Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Response To Radiation Positive Regulation Of Non-canonical Wnt Signaling Pathway Cytoplasm Lactate Metabolic Process Regulation Of Hormone Secretion Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Microtubule Nucleation Protein Phosphorylation Response To Muscle Activity Negative Regulation Of Signal Transduction Positive Regulation Of Wnt Signaling Pathway Lipid Storage Regulation Of G Protein-coupled Receptor Signaling Pathway Dopaminergic Neuron Differentiation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Phosphorylation Negative Regulation Of Lipid Transport FAD Binding Protein Serine/threonine Kinase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?