PER1 and CRY2

Number of citations of the paper that reports this interaction (PMID 12782655)
22

Data Source:
HPRD (in vitro, in vivo)

		PER1	CRY2
Gene Name		period circadian clock 1	cryptochrome circadian clock 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Extracellular Region Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Binding Transcription Factor Activity Signal Transducer Activity Transcription Factor Binding Kinase Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding E-box Binding	Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Binding Transcription Factor Activity DNA Binding Damaged DNA Binding Single-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Blue Light Photoreceptor Activity Phosphatase Binding Ubiquitin Binding FAD Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sodium Ion Transport Transcription, DNA-templated Signal Transduction Circadian Rhythm Entrainment Of Circadian Clock Posttranscriptional Regulation Of Gene Expression Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Regulation Of Circadian Rhythm Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Entrainment Of Circadian Clock By Photoperiod Histone H3 Acetylation Histone H4 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of JNK Cascade Response To CAMP Histone H3 Deacetylation Circadian Regulation Of Translation Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of P38MAPK Cascade Negative Regulation Of Glucocorticoid Receptor Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Photoreactive Repair Transcription, DNA-templated Circadian Rhythm Blue Light Signaling Pathway Protein-chromophore Linkage Negative Regulation Of Phosphoprotein Phosphatase Activity Circadian Regulation Of Gene Expression Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transcription, DNA-templated Regulation Of Sodium-dependent Phosphate Transport Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression	BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS			Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Visceral fat ( 22589738)
Protein-Protein Interactions		13 interactors: CCDC57 CRY1 CRY2 CSNK1D CSNK1E CSNK1G2 FAM65B GPRASP1 HIF1A PER2 PER3 RBPMS TIMELESS	11 interactors: ATXN1 BRCA1 CTBP1 MTUS2 PDE9A PER1 PER2 PER3 PPP5C TIMELESS TTC1
Entrez ID		5187	1408
HPRD ID		03774	07226
Ensembl ID		ENSG00000179094	ENSG00000121671
Uniprot IDs		O15534	B4DZD6 Q49AN0
PDB IDs		1UL6
Enriched GO Terms of Interacting Partners?		Regulation Of Circadian Rhythm Circadian Rhythm Circadian Regulation Of Gene Expression Rhythmic Process Negative Regulation Of Circadian Rhythm Blue Light Signaling Pathway Response To Blue Light Regulation Of Signaling Lactate Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Nitrogen Compound Metabolic Process Protein-chromophore Linkage Negative Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-serine Phosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Wnt Signaling Pathway Regulation Of Cell Shape Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Photoperiodism Entrainment Of Circadian Clock Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Glucose Homeostasis Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Hormone Secretion Cell Cycle Phase Transition Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Wnt Signaling Pathway RNA Metabolic Process Gluconeogenesis Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Wnt Signaling Pathway Hexose Biosynthetic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription, Termination	Negative Regulation Of Transcription, DNA-templated Regulation Of Circadian Rhythm Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Circadian Rhythm Circadian Regulation Of Translation Regulation Of Transcription From RNA Polymerase II Promoter Circadian Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Rhythmic Process Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process RNA Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Histone H4 Acetylation Negative Regulation Of Histone Acetylation White Fat Cell Differentiation Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Protein Acetylation Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone H3 Deacetylation Biosynthetic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of Histone Acetylation Nitrogen Compound Metabolic Process Histone Deacetylation Protein Deacetylation Positive Regulation Of Histone Modification Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Negative Regulation Of DNA-templated Transcription, Termination Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Histone Modification Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Chromosome Organization Organelle Organization Response To Radiation Response To Abiotic Stimulus Negative Regulation Of Fat Cell Proliferation
Tagcloud ?		acutely afternoon bmal1 boivin bright cermakian circadian clock clocks cortef cuesta desynchronization entrain entrained glucocorticoids innovative jet lag night pbmcs per2 reset rhythms shifted synchronize synchronizers synchronizing travelers underlines	aiming arntl2 circadian clinicopathological clock clockwork coefficients compromised coordinated disturbances fdr functionality indicative metastasizing mfs neoadjuvant nfil3 npas2 pairwise per1 per2 per3 progressed rhythm rorc stratification stronger systematically weaker
Tagcloud (Difference) ?		acutely afternoon bmal1 boivin bright cermakian clocks cortef cuesta desynchronization entrain entrained glucocorticoids innovative jet lag night pbmcs reset rhythms shifted synchronize synchronizers synchronizing travelers underlines	aiming arntl2 clinicopathological clockwork coefficients compromised coordinated disturbances fdr functionality indicative metastasizing mfs neoadjuvant nfil3 npas2 pairwise per3 progressed rhythm rorc stratification stronger systematically weaker
Tagcloud (Intersection) ?		circadian clock per1 per2