LTB4R2 and FOLR1

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		LTB4R2	FOLR1
Name		leukotriene B4 receptor 2	folate receptor alpha
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Membrane	Golgi Membrane Extracellular Region Nucleus Endosome Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Clathrin-coated Vesicle Cytoplasmic Vesicle Brush Border Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Exosome Side Of Membrane
	Molecular Function	Leukotriene B4 Receptor Activity G Protein-coupled Receptor Activity Leukotriene Receptor Activity G Protein-coupled Peptide Receptor Activity	Protein Binding Folic Acid Binding Signaling Receptor Activity Folic Acid Receptor Activity
	Biological Process	Chemotaxis Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Neuropeptide Signaling Pathway Keratinocyte Migration Leukotriene Signaling Pathway	Heart Looping Neural Crest Cell Migration Involved In Heart Formation Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Receptor-mediated Endocytosis Cell Adhesion Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Folic Acid Transport Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Axon Regeneration Sperm-egg Recognition Tetrahydrofolate Biosynthetic Process Folic Acid Metabolic Process Response To Axon Injury Regulation Of Canonical Wnt Signaling Pathway Pharyngeal Arch Artery Morphogenesis Anterior Neural Tube Closure Cellular Response To Folic Acid
Pathways		Leukotriene receptors G alpha (q) signalling events	COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport
Drugs		Amelubant Leukotriene B4	Folic acid Vintafolide Farletuzumab Mirvetuximab soravtansine Pafolacianine
GWAS		Anorectal malformation ( 31136621 ) Height ( 28552196 )	No GWAS studies recorded
Interacting Genes		46 interacting genes: AKT1 AP2M1 CANX CEBPZ CERS1 CHPT1 CNOT10 CRELD2 CSNK2B CTSA DDOST FOLR1 GJC2 GLOD4 GPR146 GPR37 HLA-A IL17RD IMP4 LAMP5 MDH1 MGLL MYO1E OBSL1 P4HTM PER1 PIGM PKD1 RPN2 SCARB1 SEC13 SGCB SLC2A1 STMN3 SV2A SYNGR2 TMED1 TMEM94 TMUB2 TSPAN3 TSPAN4 TSPAN7 TTC9B VPS25 WFS1 YIF1B	6 interacting genes: CUL3 IRAK3 LTB4R2 LYN NCAPH2 SLC35F6
Entrez ID		56413	2348
HPRD ID		16153	00638
Ensembl ID		ENSG00000213906	ENSG00000110195
Uniprot IDs		B4E292 Q9NPC1	P15328
PDB IDs		Not available	4KM6 4KM7 4KMX 4LRH 5IZQ
GO Terms Enriched among Interactors		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Extracellular Exosome Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vesicle Oligosaccharyltransferase Complex B	Regulation Of Cellular Component Organization Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Lipopolysaccharide-mediated Signaling Pathway Nuclear RNA Surveillance RNA Surveillance Positive Regulation Of Chromosome Separation RNA Polymerase II Transcription Initiation Surveillance Mononuclear Cell Differentiation Nucleobase-containing Compound Catabolic Process Positive Regulation Of Macrophage Tolerance Induction Leukocyte Differentiation Regulation Of Chromosome Separation Cytokine-mediated Signaling Pathway Positive Regulation Of Defense Response Positive Regulation Of Oligodendrocyte Progenitor Proliferation Trophectodermal Cellular Morphogenesis Liver Morphogenesis Female Meiosis Chromosome Separation Leukotriene B4 Receptor Activity Response To Amino Acid Negative Regulation Of Catalytic Activity Regulation Of Oligodendrocyte Progenitor Proliferation Pattern Recognition Receptor Signaling Pathway Platelet Degranulation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Histamine Secretion By Mast Cell Negative Regulation Of Mast Cell Proliferation Negative Regulation Of MAPK Cascade Myeloid Leukocyte Differentiation Fc Receptor Mediated Inhibitory Signaling Pathway Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Eosinophil Differentiation Glycosphingolipid Binding Postsynaptic Specialization, Intracellular Component Positive Regulation Of Mast Cell Proliferation Integrin Alpha2-beta1 Complex Tolerance Induction To Self Antigen Response To Insulin Interleukin-5-mediated Signaling Pathway Positive Regulation Of Dendritic Cell Apoptotic Process 3',5'-cGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Mitochondrion Organization Cellular Response To Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of CGMP-mediated Signaling CGMP Catabolic Process Regulation Of Organelle Organization Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine