LTB4R2 and CERS1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		LTB4R2	CERS1
Description		leukotriene B4 receptor 2	ceramide synthase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Leukotriene B4 Receptor Activity G Protein-coupled Receptor Activity Leukotriene Receptor Activity G Protein-coupled Peptide Receptor Activity	N-acyltransferase Activity Transferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Chemotaxis Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Neuropeptide Signaling Pathway Keratinocyte Migration Leukotriene Signaling Pathway	Lipid Metabolic Process Sphingolipid Metabolic Process Brain Development Negative Regulation Of Cardiac Muscle Hypertrophy Sphingolipid Biosynthetic Process Cellular Response To Mycotoxin Negative Regulation Of D-glucose Import Ceramide Biosynthetic Process Cellular Response To Xenobiotic Stimulus Cellular Response To UV-A Cellular Response To Dithiothreitol Positive Regulation Of Mitophagy
Pathways		Leukotriene receptors G alpha (q) signalling events	Sphingolipid de novo biosynthesis
Drugs		Amelubant Leukotriene B4
Diseases
GWAS		Anorectal malformation ( 31136621) Height ( 28552196)
Interacting Genes		46 interacting genes: AKT1 AP2M1 CANX CEBPZ CERS1 CHPT1 CNOT10 CRELD2 CSNK2B CTSA DDOST FOLR1 GJC2 GLOD4 GPR146 GPR37 HLA-A IL17RD IMP4 LAMP5 MDH1 MGLL MYO1E OBSL1 P4HTM PER1 PIGM PKD1 RPN2 SCARB1 SEC13 SGCB SLC2A1 STMN3 SV2A SYNGR2 TMED1 TMEM94 TMUB2 TSPAN3 TSPAN4 TSPAN7 TTC9B VPS25 WFS1 YIF1B	5 interacting genes: BDKRB1 DRD2 HTR4 LTB4R2 MAPK6
Entrez ID		56413	10715
HPRD ID		16153	12114
Ensembl ID		ENSG00000213906	ENSG00000223802
Uniprot IDs		B4E292 Q9NPC1	B4DE47 P27544 Q5XG75
PDB IDs
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Extracellular Exosome Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vesicle Oligosaccharyltransferase Complex B	G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Blood Pressure Cell Migration Signal Transduction Regulation Of Blood Pressure Regulation Of Sequestering Of Calcium Ion Cell Motility Bradykinin Receptor Activity Negative Regulation Of Synaptic Transmission, Glutamatergic Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Histamine Regulation Of Synapse Structural Plasticity Dopamine Binding Regulation Of Renal Sodium Excretion Dopamine Neurotransmitter Receptor Activity Regulation Of Synapse Organization Cerebral Cortex GABAergic Interneuron Migration Chemical Synaptic Transmission Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Complex Catecholamine Uptake Dopamine Uptake Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Adenohypophysis Development Negative Regulation Of Dephosphorylation Response To Inactivity Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Negative Regulation Of Neuron Migration Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Neuron-neuron Synaptic Transmission Interneuron Migration From The Subpallium To The Cortex Branching Morphogenesis Of A Nerve Negative Regulation Of Dopamine Secretion Peristalsis Regulation Of Body Fluid Levels Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Neurotransmitter Uptake Regulation Of Dopamine Uptake Involved In Synaptic Transmission Heterotrimeric G-protein Binding Regulation Of Locomotion Involved In Locomotory Behavior Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Urine Volume
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