PER1 and CCDC57

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		PER1	CCDC57
Gene Name		period circadian clock 1	coiled-coil domain containing 57
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Binding Transcription Factor Activity Signal Transducer Activity Transcription Factor Binding Kinase Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding E-box Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sodium Ion Transport Transcription, DNA-templated Signal Transduction Circadian Rhythm Entrainment Of Circadian Clock Posttranscriptional Regulation Of Gene Expression Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Regulation Of Circadian Rhythm Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Entrainment Of Circadian Clock By Photoperiod Histone H3 Acetylation Histone H4 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of JNK Cascade Response To CAMP Histone H3 Deacetylation Circadian Regulation Of Translation Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of P38MAPK Cascade Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: CCDC57 CRY1 CRY2 CSNK1D CSNK1E CSNK1G2 FAM65B GPRASP1 HIF1A PER2 PER3 RBPMS TIMELESS	42 interactors: AES AQP1 ARL4A CBX8 CCDC120 CDC20B CEP57L1 CWF19L2 FAM161A FAM50B FAM90A1 GPKOW HAUS1 HBA2 KIAA0368 LENG1 LINC00526 MFAP1 NAPRT NELFE NUMA1 PER1 PPHLN1 PPP1R18 PRAM1 PRPF31 PRR3 PTPN7 RAB3IL1 ROBO3 SFI1 SIRPA TBC1D22B TMEM100 TSGA10IP USP15 USP2 UTP14C ZFC3H1 ZGPAT ZMAT2 ZNF417
Entrez ID		5187	284001
HPRD ID		03774	14150
Ensembl ID		ENSG00000179094	ENSG00000176155
Uniprot IDs		O15534	Q2TAC2
PDB IDs		1UL6
Enriched GO Terms of Interacting Partners?		Regulation Of Circadian Rhythm Circadian Rhythm Circadian Regulation Of Gene Expression Rhythmic Process Negative Regulation Of Circadian Rhythm Blue Light Signaling Pathway Response To Blue Light Regulation Of Signaling Lactate Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Nitrogen Compound Metabolic Process Protein-chromophore Linkage Negative Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-serine Phosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Wnt Signaling Pathway Regulation Of Cell Shape Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Photoperiodism Entrainment Of Circadian Clock Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Glucose Homeostasis Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Hormone Secretion Cell Cycle Phase Transition Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Wnt Signaling Pathway RNA Metabolic Process Gluconeogenesis Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Wnt Signaling Pathway Hexose Biosynthetic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription, Termination	Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transcription From RNA Polymerase II Promoter Photoperiodism Entrainment Of Circadian Clock Bicarbonate Transport Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development Maintenance Of Symbiont-containing Vacuole By Host Transepithelial Water Transport Nicotinate Nucleotide Salvage
Tagcloud ?		acutely afternoon bmal1 boivin bright cermakian circadian clock clocks cortef cuesta desynchronization entrain entrained glucocorticoids innovative jet lag night pbmcs per2 reset rhythms shifted synchronize synchronizers synchronizing travelers underlines
Tagcloud (Difference) ?		acutely afternoon bmal1 boivin bright cermakian circadian clock clocks cortef cuesta desynchronization entrain entrained glucocorticoids innovative jet lag night pbmcs per2 reset rhythms shifted synchronize synchronizers synchronizing travelers underlines
Tagcloud (Intersection) ?