LTB4R2 and WFS1

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		LTB4R2	WFS1
Name		leukotriene B4 receptor 2	wolframin ER transmembrane glycoprotein
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Transport Vesicle Secretory Granule Dendrite Synaptic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Leukotriene B4 Receptor Activity G Protein-coupled Receptor Activity Leukotriene Receptor Activity G Protein-coupled Peptide Receptor Activity	Protein Binding Calmodulin Binding Ubiquitin Protein Ligase Binding Calcium-dependent Protein Binding ATPase Binding Proteasome Binding DNA-binding Transcription Factor Binding Protein Carrier Chaperone
	Biological Process	Chemotaxis Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Neuropeptide Signaling Pathway Keratinocyte Migration Leukotriene Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Renal Water Homeostasis ER Overload Response Visual Perception Sensory Perception Of Sound Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Endoplasmic Reticulum Unfolded Protein Response Pancreas Development Positive Regulation Of Protein Ubiquitination Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction ERAD Pathway Olfactory Behavior Glucose Homeostasis Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Growth Protein Stabilization Nervous System Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Calcium Ion Transport Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of ERAD Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Leukotriene receptors G alpha (q) signalling events	XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Amelubant Leukotriene B4	None
Diseases		None	Wolfram syndrome (WFS); DIDMOAD syndrome Type II diabetes mellitus
GWAS		Anorectal malformation ( 31136621 ) Height ( 28552196 )	Cisplatin-induced ototoxicity ( 28039263 ) High density lipoprotein cholesterol levels ( 32902719 ) Medication use (drugs used in diabetes) ( 31015401 ) Mild age-related type 2 diabetes ( 34737425 ) Type 2 diabetes ( 20581827 32499647 31118516 30718926 30297969 30054458 29632382 29358691 28869590 24509480 22885922 19734900 ) Type 2 diabetes (adjusted for BMI) ( 29632382 )
Novel Interactors		2 novel interactors: MUC1 PTGIS	6 novel interactors: ADRA2C CD59 CSDE1 FAM184B GAK S100P
Interacting Genes		46 interacting genes: AKT1 AP2M1 CANX CEBPZ CERS1 CHPT1 CNOT10 CRELD2 CSNK2B CTSA DDOST FOLR1 GJC2 GLOD4 GPR146 GPR37 HLA-A IL17RD IMP4 LAMP5 MDH1 MGLL MYO1E OBSL1 P4HTM PER1 PIGM PKD1 RPN2 SCARB1 SEC13 SGCB SLC2A1 STMN3 SV2A SYNGR2 TMED1 TMEM94 TMUB2 TSPAN3 TSPAN4 TSPAN7 TTC9B VPS25 WFS1 YIF1B	11 interacting genes: AQP6 CD79A DRD2 EIF6 F2RL1 FAM209A LTB4R2 MAPK6 SMURF1 TERF1 TRARG1
Entrez ID		56413	7466
HPRD ID		16153	05864
Ensembl ID		ENSG00000213906	ENSG00000109501
Uniprot IDs		B4E292 Q9NPC1	A0A0S2Z4V6 O76024
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Extracellular Exosome Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vesicle Oligosaccharyltransferase Complex B	Negative Regulation Of Insulin Secretion Negative Regulation Of Establishment Of Protein Localization Negative Regulation Of Peptide Secretion Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion Negative Regulation Of Catecholamine Secretion Negative Regulation Of Protein Transport Renal System Process Negative Regulation Of Secretion By Cell G Protein-coupled Receptor Activity G-protein Alpha-subunit Binding Regulation Of Insulin Secretion Negative Regulation Of Secretion Regulation Of Catecholamine Secretion Regulation Of Peptide Hormone Secretion Nitrate Transmembrane Transporter Activity Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Protein Localization To Plasma Membrane Assembly Of Large Subunit Precursor Of Preribosome Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Engulfment Of Target By Autophagosome Negative Regulation Of Protein Localization Regulation Of Establishment Of Protein Localization PH-gated Chloride Channel Activity Nitrate Transmembrane Transport G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Proteinase-activated Receptor Activity Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Protein Localization To Cell Periphery Septin Cytoskeleton Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Leukotriene B4 Receptor Activity Regulation Of Hormone Secretion Regulation Of Protein Secretion Regulation Of Amine Transport Alpha2-adrenergic Receptor Activity Regulation Of Body Fluid Levels Negative Regulation Of Activation Of Membrane Attack Complex IgM B Cell Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Receptor Signaling Pathway