LTB4R2 and IMP4

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		LTB4R2	IMP4
Name		leukotriene B4 receptor 2	IMP U3 small nucleolar ribonucleoprotein 4
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Membrane	Fibrillar Center Nucleus Nucleoplasm Nucleolus Preribosome Small-subunit Processome Mpp10 Complex Ribonucleoprotein Complex
	Molecular Function	Leukotriene B4 Receptor Activity G Protein-coupled Receptor Activity Leukotriene Receptor Activity G Protein-coupled Peptide Receptor Activity	Protein Binding RRNA Binding SnoRNA Binding RRNA Primary Transcript Binding
	Biological Process	Chemotaxis Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Neuropeptide Signaling Pathway Keratinocyte Migration Leukotriene Signaling Pathway	RRNA Processing Maturation Of SSU-rRNA Ribosome Biogenesis Ribosomal Small Subunit Biogenesis
Pathways		Leukotriene receptors G alpha (q) signalling events	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Amelubant Leukotriene B4	None
GWAS		Anorectal malformation ( 31136621 ) Height ( 28552196 )	No GWAS studies recorded
Interacting Genes		46 interacting genes: AKT1 AP2M1 CANX CEBPZ CERS1 CHPT1 CNOT10 CRELD2 CSNK2B CTSA DDOST FOLR1 GJC2 GLOD4 GPR146 GPR37 HLA-A IL17RD IMP4 LAMP5 MDH1 MGLL MYO1E OBSL1 P4HTM PER1 PIGM PKD1 RPN2 SCARB1 SEC13 SGCB SLC2A1 STMN3 SV2A SYNGR2 TMED1 TMEM94 TMUB2 TSPAN3 TSPAN4 TSPAN7 TTC9B VPS25 WFS1 YIF1B	5 interacting genes: APP LTB4R2 MPHOSPH10 S100B ZBTB7B
Entrez ID		56413	92856
HPRD ID		16153	10002
Ensembl ID		ENSG00000213906	ENSG00000136718
Uniprot IDs		B4E292 Q9NPC1	E7ENR5 Q96G21
PDB IDs		Not available	7MQ8 7MQ9 7MQA
GO Terms Enriched among Interactors		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Extracellular Exosome Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vesicle Oligosaccharyltransferase Complex B	RAGE Receptor Binding Adaptive Thermogenesis Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Neuron Differentiation Growth Cone Filopodium Positive Regulation Of Synaptic Transmission Lipoprotein Particle Memory Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Developmental Cell Growth Regulation Of Nervous System Process Microglia Development Developmental Growth Involved In Morphogenesis Positive Regulation Of G Protein-coupled Receptor Internalization Mpp10 Complex Negative Regulation Of NK T Cell Activation Negative Regulation Of NK T Cell Proliferation Positive Regulation Of SREBP Signaling Pathway Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Leukotriene B4 Receptor Activity Leukotriene Receptor Activity Central Nervous System Development Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Protein Homodimerization Activity Astrocyte Activation Involved In Immune Response Axonogenesis Low-density Lipoprotein Particle Mediated Signaling NK T Cell Differentiation Leukotriene Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission Regulation Of Synaptic Plasticity