LTB4R2 and GJC2

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		LTB4R2	GJC2
Name		leukotriene B4 receptor 2	gap junction protein gamma 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Membrane	Plasma Membrane Gap Junction Connexin Complex Membrane Myelin Sheath Anchoring Junction
	Molecular Function	Leukotriene B4 Receptor Activity G Protein-coupled Receptor Activity Leukotriene Receptor Activity G Protein-coupled Peptide Receptor Activity	Gap Junction Channel Activity Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling
	Biological Process	Chemotaxis Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Neuropeptide Signaling Pathway Keratinocyte Migration Leukotriene Signaling Pathway	Cell Communication Cell-cell Signaling Response To Toxic Substance Cell Communication By Electrical Coupling Transmembrane Transport
Pathways		Leukotriene receptors G alpha (q) signalling events	Gap junction assembly
Drugs		Amelubant Leukotriene B4	None
Diseases		None	Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
GWAS		Anorectal malformation ( 31136621 ) Height ( 28552196 )	No GWAS studies recorded
Interacting Genes		46 interacting genes: AKT1 AP2M1 CANX CEBPZ CERS1 CHPT1 CNOT10 CRELD2 CSNK2B CTSA DDOST FOLR1 GJC2 GLOD4 GPR146 GPR37 HLA-A IL17RD IMP4 LAMP5 MDH1 MGLL MYO1E OBSL1 P4HTM PER1 PIGM PKD1 RPN2 SCARB1 SEC13 SGCB SLC2A1 STMN3 SV2A SYNGR2 TMED1 TMEM94 TMUB2 TSPAN3 TSPAN4 TSPAN7 TTC9B VPS25 WFS1 YIF1B	6 interacting genes: ADRB2 CHRM2 F2RL1 GPR35 LTB4R2 PTGER4
Entrez ID		56413	57165
HPRD ID		16153	10582
Ensembl ID		ENSG00000213906	ENSG00000198835
Uniprot IDs		B4E292 Q9NPC1	A0A654IBV7 Q5T442
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Extracellular Exosome Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vesicle Oligosaccharyltransferase Complex B	G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein-containing Complex Disassembly Regulation Of Systemic Arterial Blood Pressure Vasodilation Clathrin-coated Endocytic Vesicle Membrane Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Signal Transduction Regulation Of Smooth Muscle Contraction Positive Regulation Of Mini Excitatory Postsynaptic Potential Plasma Membrane T Cell Activation Involved In Immune Response Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Negative Regulation Of Eosinophil Extravasation Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of System Process Beta2-adrenergic Receptor Activity Proteinase-activated Receptor Activity Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Negative Regulation Of Eosinophil Migration Leukotriene B4 Receptor Activity Lymphocyte Activation Involved In Immune Response Regulation Of Protein-containing Complex Disassembly Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Positive Regulation Of Glomerular Filtration Regulation Of Renin Secretion Into Blood Stream Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Integrin Activation Leukotriene Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Blood Vessel Diameter Maintenance Norepinephrine Binding Regulation Of Tube Size Cell Activation Involved In Immune Response Leukocyte Activation Involved In Immune Response Positive Regulation Of Killing Of Cells Of Another Organism Prostaglandin Receptor Activity Leukotriene Signaling Pathway Regulation Of Blood Pressure Regulation Of Muscle Contraction Response To Psychosocial Stress Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Activity Mature Conventional Dendritic Cell Differentiation