PER1 and RIPOR2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PER1	RIPOR2
Description		period circadian regulator 1	RHO family interacting cell polarization regulator 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Apical Plasma Membrane Filopodium Stereocilium Cell Projection Stereocilium Membrane Actin-based Cell Projection
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Protein Binding Kinase Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding E-box Binding DNA-binding Transcription Factor Binding	Protein Binding 14-3-3 Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Sodium Ion Transport Chromatin Remodeling Circadian Rhythm Entrainment Of Circadian Clock Post-transcriptional Regulation Of Gene Expression Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Regulation Of Circadian Rhythm Negative Regulation Of Canonical NF-kappaB Signal Transduction Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Rhythmic Process Response To CAMP Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of P38MAPK Cascade Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway	Chemotaxis Cell Adhesion Negative Regulation Of Cell Adhesion Muscle Organ Development Sensory Perception Of Sound Negative Regulation Of Signal Transduction Cell Differentiation Negative Regulation Of Rho Protein Signal Transduction Negative Regulation Of T Cell Proliferation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Filopodium Assembly Regulation Of Cell Cycle Positive Regulation Of Neutrophil Chemotaxis Regulation Of Mitotic Spindle Assembly Positive Regulation Of Myoblast Fusion Negative Regulation Of Establishment Of T Cell Polarity Negative Regulation Of Protein Localization To Cell Leading Edge Cellular Response To Chemokine Regulation Of Establishment Of Cell Polarity Positive Regulation Of Neutrophil Extravasation Negative Regulation Of T Cell Migration Negative Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity
Pathways		Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins Degradation of CRY and PER proteins	Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) High light scatter reticulocyte percentage of red cells ( 32888494)	Liver enzyme levels (alkaline phosphatase) ( 33972514)
Interacting Genes		19 interacting genes: CCDC57 CRY1 CRY2 CSNK1D CSNK1E CSNK1G2 CSNK2B DELEC1 GPRASP1 HIF1A LTB4R2 PER2 PER3 PNMA1 RBPMS RIPOR2 TIMELESS TNS2 TRIP6	6 interacting genes: MAP2K2 MTNR1B PER1 RHOA RHOC YWHAG
Entrez ID		5187	9750
HPRD ID		03774	12881
Ensembl ID		ENSG00000179094	ENSG00000111913
Uniprot IDs		O15534	A0A2R8Y7B3 A0A2R8YEE0 B7Z5J9 B7Z6D6 B7Z6U4 F5GX51 F5H029 Q9Y4F9
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Circadian Rhythm Circadian Regulation Of Gene Expression Circadian Rhythm Rhythmic Process Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Kinase Binding Negative Regulation Of Circadian Rhythm Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Response To Activity Cry-Per Complex Negative Regulation Of Glucocorticoid Secretion Nuclear Receptor Binding Response To Blue Light Response To Light Stimulus Transcription Corepressor Binding Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Photoreceptor Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Response To Radiation Positive Regulation Of Non-canonical Wnt Signaling Pathway Cytoplasm Lactate Metabolic Process Regulation Of Hormone Secretion Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Microtubule Nucleation Protein Phosphorylation Response To Muscle Activity Negative Regulation Of Signal Transduction Positive Regulation Of Wnt Signaling Pathway Lipid Storage Regulation Of G Protein-coupled Receptor Signaling Pathway Dopaminergic Neuron Differentiation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Phosphorylation Negative Regulation Of Lipid Transport FAD Binding Protein Serine/threonine Kinase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway	Skeletal Muscle Satellite Cell Migration Positive Regulation Of Lipase Activity Apical Junction Assembly Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Regulation Of Signal Transduction Negative Regulation Of Intracellular Signal Transduction Wound Healing, Spreading Of Cells Regulation Of Protein Kinase Activity Regulation Of Cell Communication Regulation Of Kinase Activity Regulation Of Signaling Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Stress Fiber Assembly Cleavage Furrow Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Vasoconstriction Positive Regulation Of Actin Filament Bundle Assembly Mitotic Cytokinesis Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Focal Adhesion Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Cytoskeleton-dependent Cytokinesis Regulation Of Stress Fiber Assembly Regulation Of Phosphorus Metabolic Process Aortic Valve Formation Cell-cell Junction Assembly Positive Regulation Of Hydrolase Activity Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Cell Motility Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Positive Regulation Of Locomotion Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Circadian Rhythm Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Protein Modification Process Beta Selection Protein Kinase C Inhibitor Activity Blood Vessel Diameter Maintenance
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