LTB4R2 and PTGIS

Data Source: HiPPIP (Novel)

		LTB4R2	PTGIS
Name		leukotriene B4 receptor 2	prostaglandin I2 synthase
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Membrane	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Caveola Membrane
	Molecular Function	Leukotriene B4 Receptor Activity G Protein-coupled Receptor Activity Leukotriene Receptor Activity G Protein-coupled Peptide Receptor Activity	Monooxygenase Activity Iron Ion Binding Protein Binding Prostaglandin-I Synthase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Lyase Activity Isomerase Activity Heme Binding Metal Ion Binding Hydroperoxy Icosatetraenoate Dehydratase Activity
	Biological Process	Chemotaxis Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Neuropeptide Signaling Pathway Keratinocyte Migration Leukotriene Signaling Pathway	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Icosanoid Metabolic Process Prostaglandin Metabolic Process Embryo Implantation NAD+ Biosynthetic Process Via The Salvage Pathway Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Prostanoid Biosynthetic Process Decidualization Negative Regulation Of Inflammatory Response Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Hypoxia Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis
Pathways		Leukotriene receptors G alpha (q) signalling events	Eicosanoids Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs		Amelubant Leukotriene B4	Phenylbutazone Epoprostenol (5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-1-Octen-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}-5-heptenoic acid
GWAS		Anorectal malformation ( 31136621 ) Height ( 28552196 )	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Schizophrenia ( 25056061 29483656 30285260 )
Novel Interactors		2 novel interactors: MUC1 PTGIS	7 novel interactors: ARFGEF2 BTF3 GMFG GNAS LTB4R2 PKHD1 TMSB4XP6
Interacting Genes		46 interacting genes: AKT1 AP2M1 CANX CEBPZ CERS1 CHPT1 CNOT10 CRELD2 CSNK2B CTSA DDOST FOLR1 GJC2 GLOD4 GPR146 GPR37 HLA-A IL17RD IMP4 LAMP5 MDH1 MGLL MYO1E OBSL1 P4HTM PER1 PIGM PKD1 RPN2 SCARB1 SEC13 SGCB SLC2A1 STMN3 SV2A SYNGR2 TMED1 TMEM94 TMUB2 TSPAN3 TSPAN4 TSPAN7 TTC9B VPS25 WFS1 YIF1B	3 interacting genes: APP PTGS1 PTGS2
Entrez ID		56413	5740
HPRD ID		16153	09046
Ensembl ID		ENSG00000213906	ENSG00000124212
Uniprot IDs		B4E292 Q9NPC1	Q16647
PDB IDs		Not available	2IAG 3B6H
GO Terms Enriched among Interactors		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Extracellular Exosome Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vesicle Oligosaccharyltransferase Complex B	Cyclooxygenase Pathway Prostaglandin-endoperoxide Synthase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Cellular Response To Catecholamine Stimulus Response To Catecholamine Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Peroxidase Activity Cellular Response To Fluid Shear Stress Prostaglandin Metabolic Process Prostanoid Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Response To Fluid Shear Stress Arachidonate Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Perinuclear Region Of Cytoplasm Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Non-ionic Osmotic Stress Regulation Of Multicellular Organism Growth Regulation Of Nitric Oxide Metabolic Process Neuron Projection Dioxygenase Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Tumor Necrosis Factor Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Inflammatory Response Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Protein Localization To Endoplasmic Reticulum Nascent Polypeptide-associated Complex Secretion By Cell Mu-type Opioid Receptor Binding Regulation Of Cholangiocyte Proliferation Cellular Detoxification Unsaturated Fatty Acid Metabolic Process