LTB4R2 and CNOT10

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		LTB4R2	CNOT10
Description		leukotriene B4 receptor 2	CCR4-NOT transcription complex subunit 10
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Membrane	Nucleus Cytoplasm Cytosol Membrane CCR4-NOT Complex
	Molecular Function	Leukotriene B4 Receptor Activity G Protein-coupled Receptor Activity Leukotriene Receptor Activity G Protein-coupled Peptide Receptor Activity	Protein Binding
	Biological Process	Chemotaxis Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Neuropeptide Signaling Pathway Keratinocyte Migration Leukotriene Signaling Pathway	Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Regulation Of Translation Negative Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing
Pathways		Leukotriene receptors G alpha (q) signalling events	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
Drugs		Amelubant Leukotriene B4
Diseases
GWAS		Anorectal malformation ( 31136621) Height ( 28552196)	Diabetic retinopathy in type 2 diabetes ( 33607655) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Sensorimotor dexterity ( 31596458)
Interacting Genes		46 interacting genes: AKT1 AP2M1 CANX CEBPZ CERS1 CHPT1 CNOT10 CRELD2 CSNK2B CTSA DDOST FOLR1 GJC2 GLOD4 GPR146 GPR37 HLA-A IL17RD IMP4 LAMP5 MDH1 MGLL MYO1E OBSL1 P4HTM PER1 PIGM PKD1 RPN2 SCARB1 SEC13 SGCB SLC2A1 STMN3 SV2A SYNGR2 TMED1 TMEM94 TMUB2 TSPAN3 TSPAN4 TSPAN7 TTC9B VPS25 WFS1 YIF1B	4 interacting genes: CHMP1B LTB4R2 OBI1 RNF10
Entrez ID		56413	25904
HPRD ID		16153	16731
Ensembl ID		ENSG00000213906	ENSG00000182973
Uniprot IDs		B4E292 Q9NPC1	Q9H9A5
PDB IDs			8BFI 8FY3
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Extracellular Exosome Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vesicle Oligosaccharyltransferase Complex B	Protein Autoubiquitination Protein Monoubiquitination Ubiquitin Protein Ligase Activity Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Leukotriene Signaling Pathway Keratinocyte Migration Negative Regulation Of Adenylate Cyclase Activity Leukotriene B4 Receptor Activity Leukotriene Receptor Activity ESCRT III Complex MIT Domain Binding Amphisome Membrane Vesicle Fusion With Vacuole ESCRT III Complex Disassembly ESCRT Complex Disassembly Viral Budding From Plasma Membrane Lysosomal Membrane Organization Multivesicular Body-lysosome Fusion Modification-dependent Protein Catabolic Process Positive Regulation Of Myelination Negative Regulation Of Glial Cell Proliferation Ubiquitin-dependent Protein Catabolic Process Plasma Membrane Repair Mitotic Cytokinetic Process Multivesicular Body Membrane Late Endosome To Lysosome Transport Kinetochore Microtubule Viral Budding Nuclear Membrane Reassembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Viral Release From Host Cell Midbody Abscission Membrane Coat Protein Ubiquitination Multivesicular Body Organization Multivesicular Body Assembly Regulation Of Spindle Assembly Epithelial Cell Migration Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation G Protein-coupled Peptide Receptor Activity Regulation Of Mitotic Spindle Organization Late Endosome To Vacuole Transport
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