PER1 and TIMELESS

Number of citations of the paper that reports this interaction (PMID 9856465)
52

Data Source:
HPRD (in vitro)

		PER1	TIMELESS
Gene Name		period circadian clock 1	timeless circadian clock
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nuclear Chromatin Nucleus Nucleolus Microtubule Cytoskeleton
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Binding Transcription Factor Activity Signal Transducer Activity Transcription Factor Binding Kinase Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding E-box Binding	Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sodium Ion Transport Transcription, DNA-templated Signal Transduction Circadian Rhythm Entrainment Of Circadian Clock Posttranscriptional Regulation Of Gene Expression Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Regulation Of Circadian Rhythm Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Entrainment Of Circadian Clock By Photoperiod Histone H3 Acetylation Histone H4 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of JNK Cascade Response To CAMP Histone H3 Deacetylation Circadian Regulation Of Translation Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of P38MAPK Cascade Negative Regulation Of Glucocorticoid Receptor Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Morphogenesis Of An Epithelium Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Mitotic Nuclear Division Circadian Rhythm Detection Of Abiotic Stimulus Response To Abiotic Stimulus Lung Development Regulation Of Cell Proliferation Regulation Of Circadian Rhythm Cell Cycle Phase Transition Negative Regulation Of Transcription, DNA-templated Branching Morphogenesis Of An Epithelial Tube Cell Division
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS			Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Protein-Protein Interactions		13 interactors: CCDC57 CRY1 CRY2 CSNK1D CSNK1E CSNK1G2 FAM65B GPRASP1 HIF1A PER2 PER3 RBPMS TIMELESS	9 interactors: CHEK1 CRY1 CRY2 PCBD1 PER1 PER2 TF TIPIN ZSCAN1
Entrez ID		5187	8914
HPRD ID		03774	04864
Ensembl ID		ENSG00000179094	ENSG00000111602
Uniprot IDs		O15534	Q9UNS1
PDB IDs		1UL6
Enriched GO Terms of Interacting Partners?		Regulation Of Circadian Rhythm Circadian Rhythm Circadian Regulation Of Gene Expression Rhythmic Process Negative Regulation Of Circadian Rhythm Blue Light Signaling Pathway Response To Blue Light Regulation Of Signaling Lactate Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Nitrogen Compound Metabolic Process Protein-chromophore Linkage Negative Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-serine Phosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Wnt Signaling Pathway Regulation Of Cell Shape Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Photoperiodism Entrainment Of Circadian Clock Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Glucose Homeostasis Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Hormone Secretion Cell Cycle Phase Transition Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Wnt Signaling Pathway RNA Metabolic Process Gluconeogenesis Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Wnt Signaling Pathway Hexose Biosynthetic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription, Termination	Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Response To Light Stimulus Photoperiodism Entrainment Of Circadian Clock Blue Light Signaling Pathway Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Radiation Circadian Rhythm Response To Blue Light Circadian Regulation Of Translation Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process DNA Damage Induced Protein Phosphorylation Rhythmic Process Cellular Response To Light Stimulus Protein-chromophore Linkage Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Cellular Response To Radiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process Histone H3 Deacetylation RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gluconeogenesis Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Histone Deacetylation Hexose Biosynthetic Process Protein Deacetylation Histone Modification RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription, Termination
Tagcloud ?		acutely afternoon bmal1 boivin bright cermakian circadian clock clocks cortef cuesta desynchronization entrain entrained glucocorticoids innovative jet lag night pbmcs per2 reset rhythms shifted synchronize synchronizers synchronizing travelers underlines	ancestral anthropogenic arthropod calanus californicus circadian clock clockwork copepod copepods crustacean cryptochrome daphnia doubletime finmarchicus inputs intertidal orange pacemaker publicly pulex rhythms shaggy stressor stressors suite supernumerary tigriopus vrille
Tagcloud (Difference) ?		acutely afternoon bmal1 boivin bright cermakian clocks cortef cuesta desynchronization entrain entrained glucocorticoids innovative jet lag night pbmcs per2 reset shifted synchronize synchronizers synchronizing travelers underlines	ancestral anthropogenic arthropod calanus californicus clockwork copepod copepods crustacean cryptochrome daphnia doubletime finmarchicus inputs intertidal orange pacemaker publicly pulex shaggy stressor stressors suite supernumerary tigriopus vrille
Tagcloud (Intersection) ?		circadian clock rhythms