PER1 and CRY1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro, in vivo)

		PER1	CRY1
Description		period circadian regulator 1	cryptochrome circadian regulator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Cytoplasm Mitochondrion
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Protein Binding Kinase Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding E-box Binding DNA-binding Transcription Factor Binding	Nucleotide Binding DNA Binding Double-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Photoreceptor Activity Blue Light Photoreceptor Activity Nuclear Receptor Binding Kinase Binding Protein Kinase Binding Phosphatase Binding Histone Deacetylase Binding E-box Binding FAD Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Sodium Ion Transport Chromatin Remodeling Circadian Rhythm Entrainment Of Circadian Clock Post-transcriptional Regulation Of Gene Expression Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Regulation Of Circadian Rhythm Negative Regulation Of Canonical NF-kappaB Signal Transduction Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Rhythmic Process Response To CAMP Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of P38MAPK Cascade Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Regulation Of Gluconeogenesis Circadian Rhythm Response To Light Stimulus Blue Light Signaling Pathway Response To Activity Lipid Storage Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Response To Insulin Circadian Regulation Of Gene Expression Response To Glucagon Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Signal Transduction In Response To DNA Damage Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Gluconeogenesis Positive Regulation Of Gluconeogenesis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of DNA Damage Checkpoint Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Negative Regulation Of Glucocorticoid Secretion
Pathways		Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins Degradation of CRY and PER proteins	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) High light scatter reticulocyte percentage of red cells ( 32888494)	Morning person ( 30696823) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		19 interacting genes: CCDC57 CRY1 CRY2 CSNK1D CSNK1E CSNK1G2 CSNK2B DELEC1 GPRASP1 HIF1A LTB4R2 PER2 PER3 PNMA1 RBPMS RIPOR2 TIMELESS TNS2 TRIP6	25 interacting genes: ARIH1 BHLHE41 BMAL1 CBLB CLOCK CSNK1E DELEC1 GRN KRTAP4-12 LTBP4 MDFI NPAS2 NR1D2 PER1 PER2 PER3 PLSCR1 PPP2R1B PPP2R5D PPP2R5E SNRPD3 TIMELESS TRAF2 USP2 USP7
Entrez ID		5187	1407
HPRD ID		03774	09050
Ensembl ID		ENSG00000179094	ENSG00000008405
Uniprot IDs		O15534	A2I2P0 Q16526
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Circadian Rhythm Circadian Regulation Of Gene Expression Circadian Rhythm Rhythmic Process Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Kinase Binding Negative Regulation Of Circadian Rhythm Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Response To Activity Cry-Per Complex Negative Regulation Of Glucocorticoid Secretion Nuclear Receptor Binding Response To Blue Light Response To Light Stimulus Transcription Corepressor Binding Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Photoreceptor Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Response To Radiation Positive Regulation Of Non-canonical Wnt Signaling Pathway Cytoplasm Lactate Metabolic Process Regulation Of Hormone Secretion Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Microtubule Nucleation Protein Phosphorylation Response To Muscle Activity Negative Regulation Of Signal Transduction Positive Regulation Of Wnt Signaling Pathway Lipid Storage Regulation Of G Protein-coupled Receptor Signaling Pathway Dopaminergic Neuron Differentiation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Phosphorylation Negative Regulation Of Lipid Transport FAD Binding Protein Serine/threonine Kinase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway	Circadian Rhythm Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Rhythmic Process Photoperiodism CLOCK-BMAL Transcription Complex Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Response To Redox State E-box Binding Protein Phosphatase Type 2A Complex Negative Regulation Of RNA Metabolic Process Circadian Behavior Nucleoplasm Rhythmic Behavior Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Hair Cycle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Phosphatase Regulator Activity Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Corepressor Binding Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Primary Metabolic Process Response To Light Stimulus Meiotic Sister Chromatid Cohesion Regulation Of RNA Metabolic Process Protein Dimerization Activity Negative Regulation Of Macromolecule Metabolic Process Chromatoid Body Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Membrane Raft Regulation Of Nucleobase-containing Compound Metabolic Process Protein Phosphatase Activator Activity Positive Regulation Of Circadian Rhythm Protein Stabilization Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Response To Radiation Regulation Of Transcription By RNA Polymerase II Regulation Of Skeletal Muscle Cell Differentiation Transcription Cis-regulatory Region Binding
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