LTB4R2 and MDH1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		LTB4R2	MDH1
Description		leukotriene B4 receptor 2	malate dehydrogenase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Membrane	Extracellular Space Cytoplasm Centrosome Cytosol Extracellular Exosome
	Molecular Function	Leukotriene B4 Receptor Activity G Protein-coupled Receptor Activity Leukotriene Receptor Activity G Protein-coupled Peptide Receptor Activity	Catalytic Activity Malic Enzyme Activity Protein Binding Oxidoreductase Activity Malate Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor L-malate Dehydrogenase (NAD+) Activity Diiodophenylpyruvate Reductase (NAD+) Activity (2R)-hydroxyphenylpyruvate Reductase [NAD(P)H] Activity
	Biological Process	Chemotaxis Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Neuropeptide Signaling Pathway Keratinocyte Migration Leukotriene Signaling Pathway	Tricarboxylic Acid Cycle Oxaloacetate Metabolic Process Malate Metabolic Process NADP+ Metabolic Process NAD+ Metabolic Process Carboxylic Acid Metabolic Process Malate-aspartate Shuttle
Pathways		Leukotriene receptors G alpha (q) signalling events	Malate-aspartate shuttle
Drugs		Amelubant Leukotriene B4	NADH Nicotinamide adenine dinucleotide phosphate Artenimol
Diseases
GWAS		Anorectal malformation ( 31136621) Height ( 28552196)	Asthma and attention deficit hyperactivity disorder ( 31619474) Blood protein levels ( 30072576) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		46 interacting genes: AKT1 AP2M1 CANX CEBPZ CERS1 CHPT1 CNOT10 CRELD2 CSNK2B CTSA DDOST FOLR1 GJC2 GLOD4 GPR146 GPR37 HLA-A IL17RD IMP4 LAMP5 MDH1 MGLL MYO1E OBSL1 P4HTM PER1 PIGM PKD1 RPN2 SCARB1 SEC13 SGCB SLC2A1 STMN3 SV2A SYNGR2 TMED1 TMEM94 TMUB2 TSPAN3 TSPAN4 TSPAN7 TTC9B VPS25 WFS1 YIF1B	15 interacting genes: CDC42 CHRM2 EGFR ERBB2 FUS GPD1 HSD17B10 HSPB2 LTB4R2 MPP3 SERPINB5 TERF1 TERF2IP TP53 TTC3
Entrez ID		56413	4190
HPRD ID		16153	01100
Ensembl ID		ENSG00000213906	ENSG00000014641
Uniprot IDs		B4E292 Q9NPC1	A0A5K1VW95 P40925 V9HWF2
PDB IDs			7RM9 7RRL
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Extracellular Exosome Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vesicle Oligosaccharyltransferase Complex B	Negative Regulation Of Telomere Maintenance Shelterin Complex Regulation Of DNA Metabolic Process ERBB2-EGFR Signaling Pathway Nuclear Telomere Cap Complex Negative Regulation Of Chromosome Organization Telomere Capping G-rich Strand Telomeric DNA Binding Regulation Of Phosphorus Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Regulation Of DNA Replication Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase ERBB2 Signaling Pathway Negative Regulation Of DNA Metabolic Process Negative Regulation Of DNA Replication RNA-templated DNA Biosynthetic Process Regulation Of Epithelial Cell Proliferation Gland Morphogenesis Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cell Growth Regulation Of Cell Growth Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Organelle Organization Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Multivesicular Body, Internal Vesicle Lumen Molecular Condensate Scaffold Activity Glycerol-3-phosphate Dehydrogenase (NAD+) Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Regulation Of Cellular Response To Stress Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Repair
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