PER1 and PER3

Number of citations of the paper that reports this interaction (PubMedID 10837028)
35

Data Source:
HPRD (in vitro)

		PER1	PER3
Description		period circadian regulator 1	period circadian regulator 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Protein Binding Kinase Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding E-box Binding DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding Transcription Corepressor Binding Protein Binding Kinase Binding Ubiquitin Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Sodium Ion Transport Chromatin Remodeling Circadian Rhythm Entrainment Of Circadian Clock Post-transcriptional Regulation Of Gene Expression Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Regulation Of Circadian Rhythm Negative Regulation Of Canonical NF-kappaB Signal Transduction Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Rhythmic Process Response To CAMP Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of P38MAPK Cascade Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Regulation Of Circadian Sleep/wake Cycle, Sleep Rhythmic Process Protein Stabilization
Pathways		Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins Degradation of CRY and PER proteins	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins Degradation of CRY and PER proteins
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) High light scatter reticulocyte percentage of red cells ( 32888494)	Chronotype ( 30696823) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600) Ulcerative colitis ( 28067908)
Interacting Genes		19 interacting genes: CCDC57 CRY1 CRY2 CSNK1D CSNK1E CSNK1G2 CSNK2B DELEC1 GPRASP1 HIF1A LTB4R2 PER2 PER3 PNMA1 RBPMS RIPOR2 TIMELESS TNS2 TRIP6	9 interacting genes: BMAL1 CLOCK CRY1 CRY2 CSNK1D CSNK1E PER1 PER2 SP1
Entrez ID		5187	8863
HPRD ID		03774	09138
Ensembl ID		ENSG00000179094	ENSG00000049246
Uniprot IDs		O15534	A0A087WV69 A2I2N5 P56645
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Circadian Rhythm Circadian Regulation Of Gene Expression Circadian Rhythm Rhythmic Process Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Kinase Binding Negative Regulation Of Circadian Rhythm Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Response To Activity Cry-Per Complex Negative Regulation Of Glucocorticoid Secretion Nuclear Receptor Binding Response To Blue Light Response To Light Stimulus Transcription Corepressor Binding Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Photoreceptor Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Response To Radiation Positive Regulation Of Non-canonical Wnt Signaling Pathway Cytoplasm Lactate Metabolic Process Regulation Of Hormone Secretion Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Microtubule Nucleation Protein Phosphorylation Response To Muscle Activity Negative Regulation Of Signal Transduction Positive Regulation Of Wnt Signaling Pathway Lipid Storage Regulation Of G Protein-coupled Receptor Signaling Pathway Dopaminergic Neuron Differentiation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Phosphorylation Negative Regulation Of Lipid Transport FAD Binding Protein Serine/threonine Kinase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway	Circadian Regulation Of Gene Expression Rhythmic Process Regulation Of Circadian Rhythm Circadian Rhythm Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Photoperiodism Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock E-box Binding Negative Regulation Of Circadian Rhythm Regulation Of Hormone Secretion Transcription Cis-regulatory Region Binding Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Response To Light Stimulus Regulation Of Hair Cycle Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Cry-Per Complex Response To Radiation Negative Regulation Of Glucocorticoid Secretion CLOCK-BMAL Transcription Complex Regulation Of Hormone Levels Response To Blue Light Regulation Of Secretion By Cell Regulation Of Signal Transduction Regulation Of Secretion Regulation Of Type B Pancreatic Cell Development Regulation Of Gene Expression Photoreceptor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process Kinase Binding Positive Regulation Of Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Chromatoid Body Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Response To Redox State Positive Regulation Of Protein Metabolic Process Positive Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Cell Communication
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