LTB4R2 and MYO1E

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		LTB4R2	MYO1E
Name		leukotriene B4 receptor 2	myosin IE
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Membrane	Cytoplasm Cytoskeleton Plasma Membrane Microvillus Brush Border Adherens Junction Actin Cytoskeleton Myosin Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Clathrin-coated Endocytic Vesicle Extracellular Exosome Anchoring Junction
	Molecular Function	Leukotriene B4 Receptor Activity G Protein-coupled Receptor Activity Leukotriene Receptor Activity G Protein-coupled Peptide Receptor Activity	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Lipid Binding ATP Hydrolysis Activity Phosphatidylinositol Binding Actin Filament Binding
	Biological Process	Chemotaxis Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Neuropeptide Signaling Pathway Keratinocyte Migration Leukotriene Signaling Pathway	Vasculogenesis In Utero Embryonic Development Kidney Development Glomerular Filtration Endocytosis Actin Filament Organization Hemopoiesis Glomerulus Development Glomerular Basement Membrane Development Post-embryonic Hemopoiesis Platelet-derived Growth Factor Receptor Signaling Pathway Podocyte Development
Pathways		Leukotriene receptors G alpha (q) signalling events	None
Drugs		Amelubant Leukotriene B4	Imidazole
GWAS		Anorectal malformation ( 31136621 ) Height ( 28552196 )	Adult body size ( 32376654 ) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444 ) Metabolite levels ( 22916037 ) Plateletcrit ( 32888494 ) Pulse pressure ( 30224653 ) Serum metabolite levels (CMS) ( 31636271 ) Social communication problems ( 24047820 )
Interacting Genes		46 interacting genes: AKT1 AP2M1 CANX CEBPZ CERS1 CHPT1 CNOT10 CRELD2 CSNK2B CTSA DDOST FOLR1 GJC2 GLOD4 GPR146 GPR37 HLA-A IL17RD IMP4 LAMP5 MDH1 MGLL MYO1E OBSL1 P4HTM PER1 PIGM PKD1 RPN2 SCARB1 SEC13 SGCB SLC2A1 STMN3 SV2A SYNGR2 TMED1 TMEM94 TMUB2 TSPAN3 TSPAN4 TSPAN7 TTC9B VPS25 WFS1 YIF1B	7 interacting genes: ACTB CLIC6 CREBBP LTB4R2 PDE4B RIPK4 SRPK2
Entrez ID		56413	4643
HPRD ID		16153	03281
Ensembl ID		ENSG00000213906	ENSG00000157483
Uniprot IDs		B4E292 Q9NPC1	Q12965 Q4KMR3
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Extracellular Exosome Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vesicle Oligosaccharyltransferase Complex B	Positive Regulation Of Double-strand Break Repair Positive Regulation Of DNA Recombination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Chromatin Regulation Of Double-strand Break Repair Via Homologous Recombination Tau Protein Binding Multicellular Organismal-level Homeostasis Regulation Of Norepinephrine Uptake Positive Regulation Of Norepinephrine Uptake Transporter Regulator Activity Cellular Response To Cytochalasin B Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Zygotic Specification Of Dorsal/ventral Axis Type I Activin Receptor Binding Negative Regulation Of Relaxation Of Cardiac Muscle D2 Dopamine Receptor Binding D4 Dopamine Receptor Binding D3 Dopamine Receptor Binding Leukotriene B4 Receptor Activity Leukotriene Receptor Activity Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Positive Regulation Of DNA Repair Regulation Of Transepithelial Transport Protein Localization To Adherens Junction Dense Body MRF Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Nuclear Speck Organization Leukotriene Signaling Pathway Chromatin Remodeling Anatomical Structure Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Morphogenesis Of A Polarized Epithelium Activin Receptor Binding Regulation Of Relaxation Of Cardiac Muscle Keratinocyte Migration Structural Constituent Of Postsynaptic Actin Cytoskeleton Negative Regulation Of Relaxation Of Muscle Positive Regulation Of Biosynthetic Process