CNTRL and SPTAN1

		CNTRL	SPTAN1
Description		centriolin	spectrin alpha, non-erythrocytic 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Centriolar Satellite Ciliary Basal Body Perinuclear Region Of Cytoplasm Meiotic Spindle Flemming Body Meiotic Spindle Pole Mitotic Spindle Pole Centriolar Subdistal Appendage	Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Microtubule Cytoskeleton Membrane Cell Junction Cortical Actin Cytoskeleton Specific Granule Lumen Cell Projection Extracellular Exosome Extracellular Vesicle Tertiary Granule Lumen
	Molecular Function	Protein Binding	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Kidney Development Cardiac Septum Development Ventricular Septum Development Aorta Development Cell Division Coronary Vasculature Development	Actin Cytoskeleton Organization Actin Filament Capping
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Caspase-mediated cleavage of cytoskeletal proteins Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade Neutrophil degranulation COPI-mediated anterograde transport RHOU GTPase cycle RHOV GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Pulse pressure ( 27841878)	Axial length ( 24144296) Body mass index ( 26426971)
Interacting Genes		5 interacting genes: CREBBP MAP3K4 MAPK6 TRADD TSC1	60 interacting genes: ABI1 ABL1 ACP1 ACTA1 ACTB AKIP1 ANK1 CAPN1 CASP3 CASP7 CEP63 CREBBP CTNNA1 DDX24 DES EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D ITSN1 KALRN KARS1 MAPK6 NEFL PCNT PDE4D PIN4 PLEC PLEKHA5 PRKCB PSMG1 PTEN PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SPTBN4 SRC STAT1 SUMO2 SYN1 TAF1 TANC1 TES TSSC4 TTC3 ZNF333
Entrez ID		11064	6709
HPRD ID		05691	01684
Ensembl ID		ENSG00000119397	ENSG00000197694
Uniprot IDs		B2RP65 Q5JVD1 Q7Z7A1	A0A0D9SF54 A0A0D9SFF6 A0A0D9SGF6 A0A384P5S9 A0A994J6W3 Q13813
PDB IDs			2FOT 3F31 3FB2 5FW9 5FWB 5FWC 6ZEH
Enriched GO Terms of Interacting Partners?		Histone H3K18 Acetyltransferase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Signal Transduction Intracellular Signaling Cassette N-terminal Peptidyl-lysine Acetylation Response To Oxygen Levels Intracellular Signal Transduction Positive Regulation Of Signaling Histone H3K27 Acetyltransferase Activity Response To Decreased Oxygen Levels Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Peptide Lactyltransferase (CoA-dependent) Activity Canonical NF-kappaB Signal Transduction Atrioventricular Canal Morphogenesis Cell Migration Involved In Endocardial Cushion Formation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of Intracellular Signal Transduction Endothelial Microparticle Galactose Binding Endocardial Cushion To Mesenchymal Transition Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Detection Of Hypoxia Primary Sex Determination Male Germ-line Sex Determination Posterior Compartment Specification Compartment Pattern Specification Anterior Compartment Pattern Formation Adult Locomotory Behavior Septin Cytoskeleton Signaling Adaptor Activity Tumor Necrosis Factor-mediated Signaling Pathway Memory T Cell Differentiation TSC1-TSC2 Complex Tumor Necrosis Factor Receptor Superfamily Complex Death Domain Binding MRF Binding Cardiac Atrium Morphogenesis Detection Of Oxygen Central Nervous System Vasculogenesis Dorsal Spinal Cord Development Adult Behavior ATPase Inhibitor Activity Regulation Of Cell Communication Response To UV Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signaling Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation	Postsynaptic Density Structural Constituent Of Cytoskeleton Cytoskeleton Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Spectrin Cytoplasm Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Cytosol Cytoskeletal Protein Binding NMDA Glutamate Receptor Activity Spectrin-associated Cytoskeleton NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Excitatory Chemical Synaptic Transmission Regulation Of System Process Glutamatergic Synapse Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Synapse Neuromuscular Process Modulation Of Chemical Synaptic Transmission Regulation Of Nervous System Process Cytoskeleton Organization Neuron Projection Regulation Of Biological Quality Ankyrin Binding Learning Or Memory Cell Junction Plasma Membrane Dendritic Spine Cell Projection Organization Associative Learning Glutamate Binding Postsynaptic Membrane Cognition Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Bounded Cell Projection Organization Spectrin Binding Cortical Cytoskeleton SH3 Domain Binding Regulation Of Membrane Potential Cell Surface Receptor Signaling Pathway Dendritic Spine Organization Actin Cytoskeleton Organization Cell Junction Organization Cellular Component Assembly Dendrite
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