CNTRL

Description		centriolin
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Centriolar Satellite Ciliary Basal Body Perinuclear Region Of Cytoplasm Meiotic Spindle Flemming Body Meiotic Spindle Pole Mitotic Spindle Pole Centriolar Subdistal Appendage
	Molecular Function	Protein Binding
	Biological Process	Kidney Development Cardiac Septum Development Ventricular Septum Development Aorta Development Cell Division Coronary Vasculature Development
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Pulse pressure ( 27841878)
Novel Interacting Genes		4 novel interacting genes: ENG PBX3 SPTAN1 TRAF1
Interacting Genes		5 interacting genes: CREBBP MAP3K4 MAPK6 TRADD TSC1
Entrez ID		11064
HPRD ID		05691
Ensembl ID		ENSG00000119397
Uniprot IDs		B2RP65 Q5JVD1 Q7Z7A1
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone H3K18 Acetyltransferase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Signal Transduction Intracellular Signaling Cassette N-terminal Peptidyl-lysine Acetylation Response To Oxygen Levels Intracellular Signal Transduction Positive Regulation Of Signaling Histone H3K27 Acetyltransferase Activity Response To Decreased Oxygen Levels Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Peptide Lactyltransferase (CoA-dependent) Activity Canonical NF-kappaB Signal Transduction Atrioventricular Canal Morphogenesis Cell Migration Involved In Endocardial Cushion Formation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of Intracellular Signal Transduction Endothelial Microparticle Galactose Binding Endocardial Cushion To Mesenchymal Transition Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Detection Of Hypoxia Primary Sex Determination Male Germ-line Sex Determination Posterior Compartment Specification Compartment Pattern Specification Anterior Compartment Pattern Formation Adult Locomotory Behavior Septin Cytoskeleton Signaling Adaptor Activity Tumor Necrosis Factor-mediated Signaling Pathway Memory T Cell Differentiation TSC1-TSC2 Complex Tumor Necrosis Factor Receptor Superfamily Complex Death Domain Binding MRF Binding Cardiac Atrium Morphogenesis Detection Of Oxygen Central Nervous System Vasculogenesis Dorsal Spinal Cord Development Adult Behavior ATPase Inhibitor Activity Regulation Of Cell Communication Response To UV Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signaling Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
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