CNTRL and PBX3

		CNTRL	PBX3
Description		centriolin	PBX homeobox 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Centriolar Satellite Ciliary Basal Body Perinuclear Region Of Cytoplasm Meiotic Spindle Flemming Body Meiotic Spindle Pole Mitotic Spindle Pole Centriolar Subdistal Appendage	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding
	Biological Process	Kidney Development Cardiac Septum Development Ventricular Septum Development Aorta Development Cell Division Coronary Vasculature Development	Eye Development Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of DNA-templated Transcription Anterior Compartment Pattern Formation Posterior Compartment Specification Brain Development Respiratory Gaseous Exchange By Respiratory System Adult Locomotory Behavior Animal Organ Morphogenesis Dorsal Spinal Cord Development Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Neuron Development
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Pulse pressure ( 27841878)	Dentures ( 31235808) Fish- and plant-related diet ( 32066663) Medication use (opioids) ( 31015401) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Pulse pressure ( 30578418) Raw vegetable consumption ( 32066663) Refractive error ( 32231278) Response to mTOR inhibitor (everolimus) ( 24009623) Sleep duration ( 30531941) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 30224653 30578418)
Interacting Genes		5 interacting genes: CREBBP MAP3K4 MAPK6 TRADD TSC1	65 interacting genes: AGTRAP ARFIP2 ARL6IP1 BIK BSND CAV3 CFTR CIDEB CMTM4 CMTM5 COQ8A CPLX2 DESI2 DGAT2L6 FADS6 FAM177A1 FKBP7 FSD2 GAD2 GBP7 HIGD1C HOXA9 HOXB8 HSD17B13 INPP5K INSYN1 ITGB3BP KRT27 KRT31 LIME1 MAGEA1 MAGEC2 MAL2 MBLAC2 MDK MEIS1 MICOS13 MTERF3 NUDT9 PKNOX1 PLIN3 PRB3 PTPN9 RABAC1 REEP5 RHBDD2 RHEX RNF186 RPRM SCAMP1 SFT2D2 SIN3A SMPD2 SYP SYPL1 TFIP11 TMCO2 TMEM196 TPD52L1 TPM3 TRAF1 TRIM44 TVP23B ZNF655 ZNHIT3
Entrez ID		11064	5090
HPRD ID		05691	15938
Ensembl ID		ENSG00000119397	ENSG00000167081
Uniprot IDs		B2RP65 Q5JVD1 Q7Z7A1	P40426 Q5JS98 Q96AL5
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone H3K18 Acetyltransferase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Signal Transduction Intracellular Signaling Cassette N-terminal Peptidyl-lysine Acetylation Response To Oxygen Levels Intracellular Signal Transduction Positive Regulation Of Signaling Histone H3K27 Acetyltransferase Activity Response To Decreased Oxygen Levels Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Peptide Lactyltransferase (CoA-dependent) Activity Canonical NF-kappaB Signal Transduction Atrioventricular Canal Morphogenesis Cell Migration Involved In Endocardial Cushion Formation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of Intracellular Signal Transduction Endothelial Microparticle Galactose Binding Endocardial Cushion To Mesenchymal Transition Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Detection Of Hypoxia Primary Sex Determination Male Germ-line Sex Determination Posterior Compartment Specification Compartment Pattern Specification Anterior Compartment Pattern Formation Adult Locomotory Behavior Septin Cytoskeleton Signaling Adaptor Activity Tumor Necrosis Factor-mediated Signaling Pathway Memory T Cell Differentiation TSC1-TSC2 Complex Tumor Necrosis Factor Receptor Superfamily Complex Death Domain Binding MRF Binding Cardiac Atrium Morphogenesis Detection Of Oxygen Central Nervous System Vasculogenesis Dorsal Spinal Cord Development Adult Behavior ATPase Inhibitor Activity Regulation Of Cell Communication Response To UV Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signaling Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation	Protein Binding
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