CNTRL and TRADD

Number of citations of the paper that reports this interaction (PMID 10187805)
48

Data Source:
HPRD (in vivo)

		CNTRL	TRADD
Gene Name		centriolin	TNFRSF1A-associated via death domain
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Membrane	Nucleus Cytoplasm Cytosol Cytoskeleton Death-inducing Signaling Complex Receptor Complex Membrane Raft
	Molecular Function	Protein Binding	Signal Transducer Activity Tumor Necrosis Factor Receptor Binding Protein Binding Kinase Binding Protein Complex Binding Identical Protein Binding Binding, Bridging Death Domain Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Cell Division	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Heterooligomerization Positive Regulation Of Hair Follicle Development Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic	Regulation by c-FLIP Dimerization of procaspase-8 Caspase-8 activation by cleavage Programmed Cell Death
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: MAP3K4 MAPK6 TRADD UBC	24 interactors: BCL10 BIRC2 CNTRL DAPK1 FADD FAS GFRA1 HIPK2 KRT14 KRT18 NGFR PPP2R1A RIPK1 STAT1 TNF TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF21 TNFRSF25 TRAF1 TRAF2 TRAF3 TRPC4AP
Entrez ID		11064	8717
HPRD ID		05691	04610
Ensembl ID		ENSG00000119397
Uniprot IDs		Q7Z7A1	B3KQZ9 Q15628
PDB IDs			1F2H 1F3V
Enriched GO Terms of Interacting Partners?		MAPK Cascade Signal Transduction By Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Activation Of MAPK Activity Male Germ-line Sex Determination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Primary Sex Determination Positive Regulation Of Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Protein Processing Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Positive Regulation Of Proteolysis Positive Regulation Of Catalytic Activity Chorionic Trophoblast Cell Differentiation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Chorion Development Apoptotic Signaling Pathway Positive Regulation Of P38MAPK Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Hair Follicle Development Viral Protein Processing Phosphorylation Intracellular Signal Transduction Response To UV-C Positive Regulation Of MAPK Cascade Cytokine-mediated Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Signal Transduction Positive Regulation Of Kinase Activity Male Sex Determination Regulation Of P38MAPK Cascade Regulation Of Hair Follicle Development Regulation Of Protein Metabolic Process Protein Metabolic Process Positive Regulation Of Transferase Activity Signaling Cellular Response To Cytokine Stimulus Cell Communication Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Hair Cycle Notch Receptor Processing	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Apoptotic Signaling Pathway Cellular Response To Tumor Necrosis Factor Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Tumor Necrosis Factor Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Peptidase Activity Cell Surface Receptor Signaling Pathway Regulation Of Endopeptidase Activity Cellular Response To Cytokine Stimulus Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Proteolysis Response To Cytokine Programmed Necrotic Cell Death Necrotic Cell Death Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Organic Substance Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Proteolysis Necroptotic Signaling Pathway Zymogen Activation Negative Regulation Of Apoptotic Process Cellular Response To Organic Substance Signal Transduction Negative Regulation Of Programmed Cell Death Response To Mechanical Stimulus Positive Regulation Of Signal Transduction Negative Regulation Of Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Necroptotic Process Signaling Cellular Response To Mechanical Stimulus Cell Communication Response To Abiotic Stimulus
Tagcloud ?		ab abi animals bmd colitic colitis dosed dosing elastic experiment extrinsic femoral femur femurs fracture halted investigates mechanical modulus neutralizing noncolitic osteoblast osteoclast prophylactically resorption scl sclerostin ultimate worse	adaptor appear characterization convey daxx death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr traf traf1 transmit
Tagcloud (Difference) ?		ab abi animals bmd colitic colitis dosed dosing elastic experiment extrinsic femoral femur femurs fracture halted investigates mechanical modulus neutralizing noncolitic osteoblast osteoclast prophylactically resorption scl sclerostin ultimate worse	adaptor appear characterization convey daxx death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr traf traf1 transmit
Tagcloud (Intersection) ?