CNTRL and ENG

		CNTRL	ENG
Description		centriolin	endoglin
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Centriolar Satellite Ciliary Basal Body Perinuclear Region Of Cytoplasm Meiotic Spindle Flemming Body Meiotic Spindle Pole Mitotic Spindle Pole Centriolar Subdistal Appendage	Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Nuclear Body Receptor Complex Endothelial Microparticle
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity Type II Transforming Growth Factor Beta Receptor Binding Protein Binding Galactose Binding Glycosaminoglycan Binding Coreceptor Activity Signaling Receptor Activator Activity Type I Transforming Growth Factor Beta Receptor Binding BMP Binding Identical Protein Binding Protein Homodimerization Activity Activin Binding Transforming Growth Factor Beta Binding
	Biological Process	Kidney Development Cardiac Septum Development Ventricular Septum Development Aorta Development Cell Division Coronary Vasculature Development	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Heart Looping Sprouting Angiogenesis Positive Regulation Of Systemic Arterial Blood Pressure Outflow Tract Septum Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Atrium Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Cell Migration Involved In Endocardial Cushion Formation Regulation Of DNA-templated Transcription Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Negative Regulation Of Gene Expression Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Vasculogenesis Extracellular Matrix Disassembly Regulation Of Cell Adhesion Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of BMP Signaling Pathway Dorsal Aorta Morphogenesis Wound Healing Regulation Of Cell Population Proliferation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Tissue Development Artery Morphogenesis Venous Blood Vessel Morphogenesis Cell Motility Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Atrial Cardiac Muscle Tissue Morphogenesis Cell Chemotaxis Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of SMAD Protein Signal Transduction Detection Of Hypoxia Endocardial Cushion To Mesenchymal Transition Vascular Associated Smooth Muscle Cell Development Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Atrioventricular Canal Morphogenesis Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs			Carotuximab
Diseases			Hereditary hemorrhagic telangiectasia (HHT)
GWAS		Pulse pressure ( 27841878)	Blood protein levels ( 30072576) Body mass index ( 26426971) Metabolic syndrome ( 20694148) Monocyte count ( 32888494)
Interacting Genes		5 interacting genes: CREBBP MAP3K4 MAPK6 TRADD TSC1	13 interacting genes: ACVR1 ACVR2A BMP2 BMP7 DYNLT4 GDF2 INHBA TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3
Entrez ID		11064	2022
HPRD ID		05691	00565
Ensembl ID		ENSG00000119397	ENSG00000106991
Uniprot IDs		B2RP65 Q5JVD1 Q7Z7A1	B7Z6Y5 F5GX88 P17813 Q5T9B9 Q96CG0
PDB IDs			5HZV 5HZW 5I04
Enriched GO Terms of Interacting Partners?		Histone H3K18 Acetyltransferase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Signal Transduction Intracellular Signaling Cassette N-terminal Peptidyl-lysine Acetylation Response To Oxygen Levels Intracellular Signal Transduction Positive Regulation Of Signaling Histone H3K27 Acetyltransferase Activity Response To Decreased Oxygen Levels Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Peptide Lactyltransferase (CoA-dependent) Activity Canonical NF-kappaB Signal Transduction Atrioventricular Canal Morphogenesis Cell Migration Involved In Endocardial Cushion Formation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of Intracellular Signal Transduction Endothelial Microparticle Galactose Binding Endocardial Cushion To Mesenchymal Transition Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Detection Of Hypoxia Primary Sex Determination Male Germ-line Sex Determination Posterior Compartment Specification Compartment Pattern Specification Anterior Compartment Pattern Formation Adult Locomotory Behavior Septin Cytoskeleton Signaling Adaptor Activity Tumor Necrosis Factor-mediated Signaling Pathway Memory T Cell Differentiation TSC1-TSC2 Complex Tumor Necrosis Factor Receptor Superfamily Complex Death Domain Binding MRF Binding Cardiac Atrium Morphogenesis Detection Of Oxygen Central Nervous System Vasculogenesis Dorsal Spinal Cord Development Adult Behavior ATPase Inhibitor Activity Regulation Of Cell Communication Response To UV Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signaling Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation	Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Response To Growth Factor Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Animal Organ Development Type II Transforming Growth Factor Beta Receptor Binding Activin Receptor Signaling Pathway Activin Binding Type III Transforming Growth Factor Beta Receptor Binding Epithelial To Mesenchymal Transition Odontogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Mesenchymal Cell Differentiation Animal Organ Morphogenesis Transforming Growth Factor Beta Binding Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Intracellular Signal Transduction Activin Receptor Complex Activin Receptor Activity, Type I Positive Regulation Of Cell Differentiation Tissue Morphogenesis Heart Development Cardiac Septum Morphogenesis Gland Morphogenesis Growth Factor Activity Cellular Response To BMP Stimulus Positive Regulation Of Developmental Process Roof Of Mouth Development Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition BMP Signaling Pathway Tube Morphogenesis Salivary Gland Morphogenesis Regulation Of Multicellular Organismal Development Anatomical Structure Morphogenesis Ventricular Septum Morphogenesis Transmembrane Receptor Protein Serine/threonine Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Secondary Palate Development Regulation Of Cell Differentiation Cytokine Activity Positive Regulation Of Signal Transduction
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