LANCL2 and RHOU

Number of citations of the paper that reports this interaction (PubMedID 26598620)
63

Data Source:
BioGRID (pull down)

		LANCL2	RHOU
Description		LanC like glutathione S-transferase 2	ras homolog family member U
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Cortical Actin Cytoskeleton	Golgi Membrane Podosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Cell Projection Anchoring Junction
	Molecular Function	Protein Binding ATP Binding GTP Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	Carbohydrate Metabolic Process Positive Regulation Of Abscisic Acid-activated Signaling Pathway Peptide Modification Negative Regulation Of DNA-templated Transcription	G1/S Transition Of Mitotic Cell Cycle Endocytosis Cytoskeleton Organization Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Rac Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Targeting To Mitochondrion
Pathways			Interleukin-4 and Interleukin-13 signaling RHOU GTPase cycle RHOU GTPase cycle
Drugs
Diseases
GWAS		Impulsivity ( 30718321) Mercury levels ( 26025379) Metabolite levels ( 23823483) QRS interval (sulfonylurea treatment interaction) ( 27958378) Spatial processing ( 31596458)	Aging ( 22773346) Basal cell carcinoma ( 18849993 24403052 25855136 27539887 33549134) Chronic lymphocytic leukemia ( 28165464) Dental caries ( 23259602) Endometriosis ( 20844546) Leukoderma in response to rhododendrol ( 32558222) Mercury levels ( 26025379) Non-melanoma skin cancer ( 29739929) Response to antidepressants in depression ( 27622933) Type 2 diabetes ( 23300278)
Interacting Genes		9 interacting genes: AKT1 APP APPBP2 RHOU SIAH1 TDRKH TERF2 TERF2IP UBC	126 interacting genes: ACAD8 ADM2 ALG13 ANGPT4 ANXA4 ANXA6 AP1S1 ARHGEF25 AS3MT ATP5MG ATP6AP1 BDNF BMAL1 BNIPL BRF1 BRINP3 C14orf119 CDKL4 CFAP100 CHRNA4 CLEC7A CPNE3 CTCF CUL5 DACT2 DMRT2 DNM2 DOK4 DSCR8 EIF4B ELP5 EMC2 ERF ERO1A FAM110B FCHO2 FKBP15 GALNTL5 GLI3 GPRIN2 GRB2 H2BC14 HCAR1 HINT3 HSD17B13 ID2 IFFO1 IL17F INSM2 JAM3 KAAG1 KIAA1191 KLRC3 LANCL2 LARS2 LAYN LMO7 LYL1 ME3 MOS MRAS MRPL15 NCK1 NCR1 NPM3 NR1H2 NRBF2 NXPH4 OXCT2 P4HTM PAK1 PAK4 PCDHGA4 PDLIM3 PGK1 PIP5K1A PLCG1 PLEK PLOD3 POT1 PRB1 PRPF18 PSMA4 PXN QTRT1 RAB40A RAD51D RALBP1 RASSF1 RBIS RPL23AP5 RPS15A RPS17P16 S100A4 SEC14L4 SEMA3G SEPTIN6 SIVA1 SKIC2 SLC26A1 SNU13 SOX4 SSC4D STX16 SYK TCN2 TEKT2 TMEM106A TMEM169 TMEM255B TRIM59 USP37 UTP3 VWA5A WNT6 XPA ZFAND2B ZFP64 ZKSCAN7 ZNF117 ZNF177 ZNF20 ZNF569 ZNF625 ZNF747 ZNF84
Entrez ID		55915	58480
HPRD ID		13956	06965
Ensembl ID		ENSG00000132434	ENSG00000116574
Uniprot IDs		B3KTN5 Q9NS86	Q7L0Q8
PDB IDs		6WQ1	2Q3H
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Recombination At Telomere Shelterin Complex Protection From Non-homologous End Joining At Telomere Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Protein Localization To Chromosome, Telomeric Region Telomere Capping Telomere Maintenance In Response To DNA Damage Enzyme Binding Post-translational Protein Modification RNA-templated DNA Biosynthetic Process Amyloid Fibril Formation Telomeric DNA Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Organization Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Modification-dependent Protein Catabolic Process Regulation Of Cellular Response To Stress Negative Regulation Of Telomere Maintenance Positive Regulation Of Nitric Oxide Metabolic Process Protein Ubiquitination Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Regulation Of Nitric Oxide Biosynthetic Process Protein Modification By Small Protein Conjugation Positive Regulation Of DNA Metabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of TRNA Methylation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination Negative Regulation Of DNA Recombination Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Male Germ Cell Nucleus Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Lymphocyte Migration Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Macromolecule Metabolic Process Negative Regulation Of Protein Localization To Lysosome Acetylcholine Receptor Activator Activity Axo-dendritic Transport	Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin
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