LANCL2 and APPBP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		LANCL2	APPBP2
Description		LanC like glutathione S-transferase 2	amyloid beta precursor protein binding protein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Cortical Actin Cytoskeleton	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Membrane Cytoplasmic Vesicle Membrane Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding ATP Binding GTP Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding	Microtubule Motor Activity Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Carbohydrate Metabolic Process Positive Regulation Of Abscisic Acid-activated Signaling Pathway Peptide Modification Negative Regulation Of DNA-templated Transcription	Intracellular Protein Transport Protein Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Transport
Pathways
Drugs
Diseases
GWAS		Impulsivity ( 30718321) Mercury levels ( 26025379) Metabolite levels ( 23823483) QRS interval (sulfonylurea treatment interaction) ( 27958378) Spatial processing ( 31596458)	Interleukin-6 levels ( 33517400) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-hip ratio ( 28552196)
Interacting Genes		9 interacting genes: AKT1 APP APPBP2 RHOU SIAH1 TDRKH TERF2 TERF2IP UBC	122 interacting genes: - AADAC ACTN1 AHCY AIM2 AK3 ALDH1L1 ANKRD10 APP AR ARMCX5 ASCC3 ATP13A1 BCL7A BIN2 C1orf50 CALM3 CCDC167 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CST2 CTC1 CYBA DCD DHRS2 DHX16 DOLK DPEP1 DPYS EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GPRC5C GSTP1 H2AC15 HGFAC HIPK4 HSD3B7 HSPA4 ITGB4 ITGB5 KHK KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MAN2B2 MCOLN1 MGAT4B MLLT3 MMP28 MRPL28 MSH2 MSLN MUL1 MYLK NFYA NHERF1 NPRL3 PCSK5 PEX39 PI4KAP2 PNPLA5 PPIL6 PPP1R8 PRKAA2 PRKACB PSAP PTCH1 PYROXD2 RAB7B RASSF5 RHEB RILPL1 RNF128 RNF34 RNGTT RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SLC33A2 SLC7A10 SNX5 SPDYE2 SPDYE2B ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 TNP2 TRMT2A UBE2R2 UGGT2 WAS WDR24 WFIKKN1 WNT5B ZC3H10 ZCCHC12 ZNF747
Entrez ID		55915	10513
HPRD ID		13956	05616
Ensembl ID		ENSG00000132434	ENSG00000062725
Uniprot IDs		B3KTN5 Q9NS86	Q92624
PDB IDs		6WQ1	8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Recombination At Telomere Shelterin Complex Protection From Non-homologous End Joining At Telomere Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Protein Localization To Chromosome, Telomeric Region Telomere Capping Telomere Maintenance In Response To DNA Damage Enzyme Binding Post-translational Protein Modification RNA-templated DNA Biosynthetic Process Amyloid Fibril Formation Telomeric DNA Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Organization Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Modification-dependent Protein Catabolic Process Regulation Of Cellular Response To Stress Negative Regulation Of Telomere Maintenance Positive Regulation Of Nitric Oxide Metabolic Process Protein Ubiquitination Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Regulation Of Nitric Oxide Biosynthetic Process Protein Modification By Small Protein Conjugation Positive Regulation Of DNA Metabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of TRNA Methylation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination Negative Regulation Of DNA Recombination Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Male Germ Cell Nucleus Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Lymphocyte Migration Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Macromolecule Metabolic Process Negative Regulation Of Protein Localization To Lysosome Acetylcholine Receptor Activator Activity Axo-dendritic Transport	Protein Binding
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