PRKCA and HIST3H3

Number of citations of the paper that reports this interaction (PMID 8375396)
11

Data Source:
BioGRID (enzymatic study, enzymatic study)

		PRKCA	HIST3H3
Gene Name		protein kinase C, alpha	histone cluster 3, H3
Image
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Dendrite Mitochondrial Membrane Neuronal Cell Body Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleosome Nucleus Nucleoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Zinc Ion Binding Enzyme Binding Histone Kinase Activity (H3-T6 Specific)	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Inactivation Of MAPK Activity Mitotic Cell Cycle Angiogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Regulation Of The Force Of Heart Contraction Chondrocyte Differentiation Desmosome Assembly Energy Reserve Metabolic Process Protein Phosphorylation Cellular Calcium Ion Homeostasis Regulation Of Muscle Contraction Mitotic Nuclear Envelope Disassembly Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Negative Regulation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Synaptic Transmission Blood Coagulation Phototransduction, Visible Light Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Platelet Activation Extracellular Matrix Organization Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Histone H3-T6 Phosphorylation Peptidyl-serine Autophosphorylation Positive Regulation Of Blood Vessel Endothelial Cell Migration Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Inflammatory Response Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Insulin Secretion Induction Of Positive Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Cellular Response To Carbohydrate Stimulus Regulation Of Platelet Aggregation Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Dense Core Granule Biogenesis	Telomere Maintenance
Pathways		Ca-dependent events Signaling by GPCR CaM pathway Signaling by FGFR in disease Phospholipase C-mediated cascade Integration of energy metabolism Mitotic Prophase Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Regulation of KIT signaling Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ G alpha (z) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Signaling by PDGF Calmodulin induced events DAP12 interactions Regulation of mRNA stability by proteins that bind AU-rich elements Opioid Signalling Diseases associated with visual transduction EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR Syndecan interactions GPCR downstream signaling Signaling by VEGF Calmodulin induced events Downstream signal transduction WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer Platelet activation, signaling and aggregation PCP/CE pathway Transmission across Chemical Synapses Trafficking of GluR2-containing AMPA receptors Nuclear Envelope Breakdown HuR stabilizes mRNA DAG and IP3 signaling M Phase VEGFA-VEGFR2 Pathway CaM pathway Inactivation, recovery and regulation of the phototransduction cascade EGFR Transactivation by Gastrin VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR The phototransduction cascade Disinhibition of SNARE formation Innate Immune System Signalling by NGF PLC beta mediated events Regulation of insulin secretion Depolymerisation of the Nuclear Lamina Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Non-integrin membrane-ECM interactions Signaling by Overexpressed Wild-Type EGFR in Cancer Trafficking of AMPA receptors Cell Cycle, Mitotic Signaling by FGFR beta-catenin independent WNT signaling Acetylcholine regulates insulin secretion Visual phototransduction Ca2+ pathway PLC-gamma1 signalling Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity	DNA Damage/Telomere Stress Induced Senescence Meiotic recombination Chromosome Maintenance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Mitotic Prophase formation of the beta-catenin:TCF transactivating complex Cellular Senescence Meiotic synapsis Signaling by Wnt Cell Cycle, Mitotic M Phase Telomere Maintenance Packaging Of Telomere Ends TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs		Phosphatidylserine Vitamin E Ingenol Mebutate Ellagic Acid
Diseases
GWAS		Height ( 22021425) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Ventricular conduction ( 21076409)
Protein-Protein Interactions		210 interactors: ACTA1 ADAP1 ADCY5 ADD3 ADRA1B ADRBK1 AFAP1 AKAP12 AKAP5 ANXA2 ANXA7 APLP2 ARHGEF1 ATP1A1 ATP2B1 ATP2B2 AVPR1A BCL2 BTG2 BTK C1QBP CASR CBL CD163 CD5 CD9 CDC42 CDKN2A CFTR CHAT CISH CORO1B CREM CYP3A4 CYTH2 DDX5 DGKD DGKZ DLG4 DLX3 DNM1 DVL2 EDF1 EEF1D EGFR EIF4E EIF4EBP1 ELAVL1 ENTPD5 EP300 EWSR1 EZR F11R FAS FBXO25 FLNA FLNC FSCN1 GABRB3 GABRG2 GABRR1 GABRR2 GFAP GFPT1 GJA1 GJB1 GLI3 GMFB GNA12 GNA15 GNB2L1 GPM6A GRIA1 GRIA2 GRIA4 GRIN1 GRIN2A GRIN2B GRM1 GRM5 GSK3A GSK3B HABP4 HAND1 HAND2 HES1 HIST1H1A HIST1H1B HIST1H1C HIST1H1D HIST1H1E HIST1H1T HIST1H3A HIST3H3 HLA-A HMGA1 HMGA2 HMGB1 HMGN1 HMGN2 HSP90AA1 HSPA1A HSPB8 IKBKB INSR ITGB1 ITGB2 ITGB4 ITPKA ITPKB KCNE1 KCNE4 KCNQ2 KIT KLF5 KRT18 LCK LMNA LMNB1 MARCKS MBP MGMT MTOR MYLK MYOD1 NCF1 NFATC1 NFE2L2 NFKBIA NOS1 NR1H2 NRGN NUMB OGG1 OPRD1 PA2G4 PAM PDLIM7 PEA15 PEBP1 PFKFB1 PFKFB2 PICK1 PLCB1 PLD1 PLD2 POLB PPARA PPARG PPP1R14A PRKCZ PRKG1 PSMB4 PTGIR PTPN11 PTPN12 PTPN6 RAC1 RAF1 RALBP1 RARA RBCK1 RGS19 RGS2 RGS7 RHO RHOA RNF31 RPL10 RRAD SACM1L SCRIB SCTR SDC2 SDC4 SDPR SELL SEMG1 SEMG2 SHC1 SLC1A1 SLC6A9 SNAP23 SNAP25 SPAG1 SPP1 SRC STXBP1 STXBP3 SYK TBXA2R TEP1 TERT THOC5 TIAM1 TNNI3 TNNT2 TNP1 TNP2 TOP2A TP53 TRIM29 TRIM41 TRPC3 TRPV6 VCL VTN XK YWHAG YWHAZ	183 interactors: ADNP AFF1 AHDC1 ANP32A ASF1A ASH2L ATAD2 AURKA AURKB BIRC5 BMI1 BPTF BRD7 C11orf30 C17orf49 CBX1 CBX2 CBX3 CBX4 CBX5 CBX7 CBX8 CCDC101 CDYL CDYL2 CHAF1A CHAF1B CHAMP1 CHD1 CHD4 CHD6 CHUK CREBBP CTBP1 CTBP2 DEK DIDO1 DOT1L DPF2 DPY30 DYRK2 EGFR EHMT1 EHMT2 EP300 ERAP1 EZH2 FOXA1 GADD45A GATAD1 GLYR1 GTF3C4 HAT1 HDAC1 HDAC2 HDAC8 HIRIP3 HMGXB4 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPK HNRNPL HNRNPR ING2 ING4 IRAK1 JADE2 JADE3 JAK1 JAK2 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3B KDM5A KDM5D KDM6A KIF2A KIF2C KMT2A KPNA1 LRIF1 LRWD1 MBD3 MCM2 MCM7 MDM2 MEN1 MGA MIER1 MLLT1 MORF4L1 MSL3 MTA1 MTA2 NAP1L4 NCL NCOA2 NCOA3 NOC2L NONO NPM1 NSD1 ORC2 ORC3 ORC4 ORC5 PCGF6 PHC2 PHC3 PHF12 PHF7 PHF8 PIM1 POGZ PPIB PPM1G PRDM2 PRKCA PRKCZ PTBP1 PTMA RAG1 RBBP4 RBBP5 RBBP7 RBP5 RCOR1 RING1 RNF2 RPS6KA3 RPS6KA5 RREB1 SAP30 SET SETD2 SETD7 SETDB1 SFPQ SIN3A SIN3B SMN1 SMNDC1 SMYD3 SUPT20H SUPT3H SUV39H1 SUZ12 TADA1 TADA3 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1A TAF2 TAF3 TAF4 TAF4B TAF5 TAF5L TAF6 TAF6L TAF7 TAF8 TAF9 TAF9B TBP TDRD3 TNPO1 TRPM7 UHRF1 VPRBP WHSC1 ZMYM4 ZNF217 ZNF516
Entrez ID		5578	8290
HPRD ID		01498	04156
Ensembl ID		ENSG00000154229	ENSG00000168148
Uniprot IDs		P17252 Q7Z727	Q16695
PDB IDs		2ELI 3IW4 4DNL	2V1D 2YBP 2YBS 3A6N 3T6R
Enriched GO Terms of Interacting Partners?		Response To Stimulus Cellular Response To Stimulus Regulation Of Signaling Signaling Cell Communication Developmental Process Response To Organic Substance Positive Regulation Of Metabolic Process Response To Stress Multicellular Organismal Development Response To Wounding Cell Differentiation Anatomical Structure Development Regulation Of Cellular Process Signal Transduction Wound Healing Regulation Of Signal Transduction Hemostasis Positive Regulation Of Cellular Metabolic Process Response To External Stimulus Blood Coagulation Regulation Of Body Fluid Levels System Development Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Locomotion Response To Organonitrogen Compound Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cell Development Regulation Of Catalytic Activity Positive Regulation Of Transport Regulation Of Metabolic Process Response To Abiotic Stimulus Movement Of Cell Or Subcellular Component Regulation Of Protein Metabolic Process Regulation Of Cellular Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Neurogenesis Nervous System Development Organ Development Generation Of Neurons Cell-cell Signaling Intracellular Signal Transduction Regulation Of Cell Differentiation Response To Organic Cyclic Compound Platelet Activation Regulation Of Cellular Protein Metabolic Process	Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Gene Expression Organelle Organization Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Biosynthetic Process Peptidyl-amino Acid Modification Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Protein Acetylation Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Regulation Of Cellular Process Metabolic Process Histone H3 Acetylation Histone Lysine Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Peptidyl-lysine Methylation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression
Tagcloud ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig rara representatives sheep southern swine synteny tk1 umph2	alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1
Tagcloud (Difference) ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig rara representatives sheep southern swine synteny tk1 umph2	alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1
Tagcloud (Intersection) ?