PRKCA and GRIN2B

Number of citations of the paper that reports this interaction (PMID 8940188)
58

Data Source:
HPRD (in vivo, in vitro)

		PRKCA	GRIN2B
Gene Name		protein kinase C, alpha	glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Image
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Dendrite Mitochondrial Membrane Neuronal Cell Body Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Neuron Projection Postsynaptic Membrane Neuronal Postsynaptic Density
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Zinc Ion Binding Enzyme Binding Histone Kinase Activity (H3-T6 Specific)	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Calcium Channel Activity Protein Binding Zinc Ion Binding Glycine Binding
	Biological Process	Inactivation Of MAPK Activity Mitotic Cell Cycle Angiogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Regulation Of The Force Of Heart Contraction Chondrocyte Differentiation Desmosome Assembly Energy Reserve Metabolic Process Protein Phosphorylation Cellular Calcium Ion Homeostasis Regulation Of Muscle Contraction Mitotic Nuclear Envelope Disassembly Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Negative Regulation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Synaptic Transmission Blood Coagulation Phototransduction, Visible Light Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Platelet Activation Extracellular Matrix Organization Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Histone H3-T6 Phosphorylation Peptidyl-serine Autophosphorylation Positive Regulation Of Blood Vessel Endothelial Cell Migration Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Inflammatory Response Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Insulin Secretion Induction Of Positive Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Cellular Response To Carbohydrate Stimulus Regulation Of Platelet Aggregation Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Dense Core Granule Biogenesis	Behavioral Fear Response In Utero Embryonic Development Startle Response Suckling Behavior Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Axon Guidance Sensory Organ Development Learning Or Memory Learning Memory Regulation Of Protein Kinase A Signaling Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Response To Ethanol Ephrin Receptor Signaling Pathway Regulation Of Synaptic Plasticity Behavioral Response To Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Regulation Of Excitatory Postsynaptic Membrane Potential Calcium Ion Transmembrane Transport
Pathways		Ca-dependent events Signaling by GPCR CaM pathway Signaling by FGFR in disease Phospholipase C-mediated cascade Integration of energy metabolism Mitotic Prophase Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Regulation of KIT signaling Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ G alpha (z) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Signaling by PDGF Calmodulin induced events DAP12 interactions Regulation of mRNA stability by proteins that bind AU-rich elements Opioid Signalling Diseases associated with visual transduction EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR Syndecan interactions GPCR downstream signaling Signaling by VEGF Calmodulin induced events Downstream signal transduction WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer Platelet activation, signaling and aggregation PCP/CE pathway Transmission across Chemical Synapses Trafficking of GluR2-containing AMPA receptors Nuclear Envelope Breakdown HuR stabilizes mRNA DAG and IP3 signaling M Phase VEGFA-VEGFR2 Pathway CaM pathway Inactivation, recovery and regulation of the phototransduction cascade EGFR Transactivation by Gastrin VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR The phototransduction cascade Disinhibition of SNARE formation Innate Immune System Signalling by NGF PLC beta mediated events Regulation of insulin secretion Depolymerisation of the Nuclear Lamina Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Non-integrin membrane-ECM interactions Signaling by Overexpressed Wild-Type EGFR in Cancer Trafficking of AMPA receptors Cell Cycle, Mitotic Signaling by FGFR beta-catenin independent WNT signaling Acetylcholine regulates insulin secretion Visual phototransduction Ca2+ pathway PLC-gamma1 signalling Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity	EPHB-mediated forward signaling Axon guidance Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII EPH-Ephrin signaling CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs		Phosphatidylserine Vitamin E Ingenol Mebutate Ellagic Acid	L-Glutamic Acid Meperidine Haloperidol Felbamate Memantine Tenocyclidine
Diseases
GWAS		Height ( 22021425) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Ventricular conduction ( 21076409)	Aging (time to event) ( 21782286) Brain structure (temporal lobe volume) ( 20197096) Cognitive performance ( 19734545) Immune reponse to smallpox (secreted IL-2) ( 22610502) Major depressive disorder ( 23377640) Ovarian reserve ( 22116950) Total ventricular volume ( 21116278)
Protein-Protein Interactions		210 interactors: ACTA1 ADAP1 ADCY5 ADD3 ADRA1B ADRBK1 AFAP1 AKAP12 AKAP5 ANXA2 ANXA7 APLP2 ARHGEF1 ATP1A1 ATP2B1 ATP2B2 AVPR1A BCL2 BTG2 BTK C1QBP CASR CBL CD163 CD5 CD9 CDC42 CDKN2A CFTR CHAT CISH CORO1B CREM CYP3A4 CYTH2 DDX5 DGKD DGKZ DLG4 DLX3 DNM1 DVL2 EDF1 EEF1D EGFR EIF4E EIF4EBP1 ELAVL1 ENTPD5 EP300 EWSR1 EZR F11R FAS FBXO25 FLNA FLNC FSCN1 GABRB3 GABRG2 GABRR1 GABRR2 GFAP GFPT1 GJA1 GJB1 GLI3 GMFB GNA12 GNA15 GNB2L1 GPM6A GRIA1 GRIA2 GRIA4 GRIN1 GRIN2A GRIN2B GRM1 GRM5 GSK3A GSK3B HABP4 HAND1 HAND2 HES1 HIST1H1A HIST1H1B HIST1H1C HIST1H1D HIST1H1E HIST1H1T HIST1H3A HIST3H3 HLA-A HMGA1 HMGA2 HMGB1 HMGN1 HMGN2 HSP90AA1 HSPA1A HSPB8 IKBKB INSR ITGB1 ITGB2 ITGB4 ITPKA ITPKB KCNE1 KCNE4 KCNQ2 KIT KLF5 KRT18 LCK LMNA LMNB1 MARCKS MBP MGMT MTOR MYLK MYOD1 NCF1 NFATC1 NFE2L2 NFKBIA NOS1 NR1H2 NRGN NUMB OGG1 OPRD1 PA2G4 PAM PDLIM7 PEA15 PEBP1 PFKFB1 PFKFB2 PICK1 PLCB1 PLD1 PLD2 POLB PPARA PPARG PPP1R14A PRKCZ PRKG1 PSMB4 PTGIR PTPN11 PTPN12 PTPN6 RAC1 RAF1 RALBP1 RARA RBCK1 RGS19 RGS2 RGS7 RHO RHOA RNF31 RPL10 RRAD SACM1L SCRIB SCTR SDC2 SDC4 SDPR SELL SEMG1 SEMG2 SHC1 SLC1A1 SLC6A9 SNAP23 SNAP25 SPAG1 SPP1 SRC STXBP1 STXBP3 SYK TBXA2R TEP1 TERT THOC5 TIAM1 TNNI3 TNNT2 TNP1 TNP2 TOP2A TP53 TRIM29 TRIM41 TRPC3 TRPV6 VCL VTN XK YWHAG YWHAZ	40 interactors: ACTN2 AP1M1 AP2M1 AP4M1 ARHGAP32 CAMK2A CAMK2B CAMK2D CAMK2G CAMK2N1 CAPN1 DLG1 DLG2 DLG3 DLG4 EPHB2 ERBB2IP EXOC4 EXOC7 FYN GNB2L1 GRIN1 GRIN3A IL16 INADL LIN7A LIN7B MAGI3 MIB2 PARK2 PIK3CA PLCG1 PRKCA PRKCB PRKCG PTPN11 SPTAN1 SRC SYNGAP1 TANC1
Entrez ID		5578	2904
HPRD ID		01498	00697
Ensembl ID		ENSG00000154229
Uniprot IDs		P17252 Q7Z727	Q13224
PDB IDs		2ELI 3IW4 4DNL	1S11 1S2S 2IPV
Enriched GO Terms of Interacting Partners?		Response To Stimulus Cellular Response To Stimulus Regulation Of Signaling Signaling Cell Communication Developmental Process Response To Organic Substance Positive Regulation Of Metabolic Process Response To Stress Multicellular Organismal Development Response To Wounding Cell Differentiation Anatomical Structure Development Regulation Of Cellular Process Signal Transduction Wound Healing Regulation Of Signal Transduction Hemostasis Positive Regulation Of Cellular Metabolic Process Response To External Stimulus Blood Coagulation Regulation Of Body Fluid Levels System Development Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Locomotion Response To Organonitrogen Compound Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cell Development Regulation Of Catalytic Activity Positive Regulation Of Transport Regulation Of Metabolic Process Response To Abiotic Stimulus Movement Of Cell Or Subcellular Component Regulation Of Protein Metabolic Process Regulation Of Cellular Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Neurogenesis Nervous System Development Organ Development Generation Of Neurons Cell-cell Signaling Intracellular Signal Transduction Regulation Of Cell Differentiation Response To Organic Cyclic Compound Platelet Activation Regulation Of Cellular Protein Metabolic Process	Synaptic Transmission Cell-cell Signaling Membrane Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Chemotaxis Signaling Cell Communication Axon Guidance Cell Projection Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuron Projection Development Receptor Localization To Synapse Regulation Of Neuronal Synaptic Plasticity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Movement Of Cell Or Subcellular Component Axonogenesis Protein Autophosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway Neuron Development Neurotrophin Signaling Pathway Learning Response To Stimulus Neuron Projection Morphogenesis Nervous System Development Locomotion Fibroblast Growth Factor Receptor Signaling Pathway Learning Or Memory Response To External Stimulus Ephrin Receptor Signaling Pathway Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Synapse Protein Localization Receptor Clustering Cognition Blood Coagulation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Body Fluid Levels Cellular Response To Stimulus Hemostasis Platelet Activation
Tagcloud ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig rara representatives sheep southern swine synteny tk1 umph2	6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Difference) ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig rara representatives sheep southern swine synteny tk1 umph2	6j 6jxm atg autosomes backcross codon crosses dispersed egr epsilon espilon exons f1xc57bl flanking grinl interspecific mapping nucleas polyadenylation primer s1 spans spl spretus termination zeta
Tagcloud (Intersection) ?