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PRKCA and HES1
Number of citations of the paper that reports this interaction (PubMedID
9389649
)
52
Data Source:
HPRD
(in vitro)
PRKCA
HES1
Description
protein kinase C alpha
hes family bHLH transcription factor 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Membrane
Mitochondrial Membrane
Protein-containing Complex
Alphav-beta3 Integrin-PKCalpha Complex
Ciliary Basal Body
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Matrix
Protein-containing Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Diacylglycerol-dependent Serine/threonine Kinase Activity
Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity
Signaling Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Diacylglycerol Binding
Histone H3T6 Kinase Activity
Metal Ion Binding
Protein Serine Kinase Activity
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity
Transcription Corepressor Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Protein Binding
JUN Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
HLH Domain Binding
Sequence-specific DNA Binding
Protein-containing Complex Binding
Protein Dimerization Activity
Protein-folding Chaperone Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
E-box Binding
N-box Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Response To Reactive Oxygen Species
Angiogenesis
Positive Regulation Of Endothelial Cell Proliferation
Desmosome Assembly
Chromatin Remodeling
Protein Phosphorylation
Apoptotic Process
Mitotic Nuclear Membrane Disassembly
Cell Adhesion
Learning Or Memory
Response To Mechanical Stimulus
Response To Toxic Substance
Positive Regulation Of Signal Transduction
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Cardiac Muscle Hypertrophy
Negative Regulation Of Translation
Central Nervous System Neuron Axonogenesis
Signal Transduction Involved In Regulation Of Gene Expression
Positive Regulation Of Cell Migration
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Insulin Secretion
Response To Estradiol
Negative Regulation Of Glial Cell Apoptotic Process
Intracellular Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Response To Peptide Hormone
Regulation Of MRNA Stability
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Response To Ethanol
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Bone Resorption
Positive Regulation Of Cell Adhesion
Positive Regulation Of Exocytosis
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Transport
Response To Corticosterone
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Synapse Assembly
Renal Sodium Ion Absorption
Positive Regulation Of ERK1 And ERK2 Cascade
Protein Kinase C Signaling
Response To Interleukin-1
Regulation Of Platelet Aggregation
Apoptotic Signaling Pathway
Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Angiotensin-activated Signaling Pathway
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Response To Phorbol 13-acetate 12-myristate
Positive Regulation Of Dense Core Granule Biogenesis
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Cell Fate Determination
Liver Development
Inhibition Of Neuroepithelial Cell Differentiation
Embryonic Heart Tube Morphogenesis
Outflow Tract Morphogenesis
Regulation Of Secondary Heart Field Cardioblast Proliferation
Ventricular Septum Development
Pancreatic A Cell Differentiation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Cell Adhesion
Notch Signaling Pathway
Smoothened Signaling Pathway
Pattern Specification Process
Nervous System Development
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Response To Virus
Anterior/posterior Pattern Specification
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Neuron Projection Development
Cell Migration
Telencephalon Development
Midbrain-hindbrain Boundary Morphogenesis
Oculomotor Nerve Development
Trochlear Nerve Development
Hindbrain Morphogenesis
Forebrain Radial Glial Cell Differentiation
Cajal-Retzius Cell Differentiation
Neural Tube Development
Central Nervous System Neuron Differentiation
Pituitary Gland Development
Adenohypophysis Development
Neuron Differentiation
Lung Development
BMP Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Midbrain Development
Pancreas Development
Somatic Stem Cell Population Maintenance
Hair Cell Differentiation
Amacrine Cell Differentiation
Aorta Morphogenesis
Ascending Aorta Morphogenesis
T Cell Proliferation
Positive Regulation Of T Cell Proliferation
Inner Ear Auditory Receptor Cell Differentiation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Regulation Of Protein-containing Complex Assembly
Response To Alkaloid
Positive Regulation Of DNA Binding
Cell Fate Commitment
Negative Regulation Of Cell Differentiation
Regulation Of Fat Cell Differentiation
Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation
Regulation Of Neuron Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Glial Cell Differentiation
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Mitotic Cell Cycle, Embryonic
Lateral Inhibition
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Cell Maturation
Regulation Of Timing Of Cell Differentiation
Thymus Development
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of Astrocyte Differentiation
Negative Regulation Of Oligodendrocyte Differentiation
Artery Morphogenesis
Regulation Of Epithelial Cell Proliferation
Regulation Of Neurogenesis
Negative Regulation Of Neurogenesis
Inner Ear Receptor Cell Stereocilium Organization
Regulation Of Timing Of Neuron Differentiation
Negative Regulation Of Glial Cell Proliferation
Ventricular Septum Morphogenesis
Ureteric Bud Morphogenesis
Labyrinthine Layer Blood Vessel Development
Common Bile Duct Development
Neuroendocrine Cell Differentiation
Stomach Neuroendocrine Cell Differentiation
Negative Regulation Of Stomach Neuroendocrine Cell Differentiation
Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis
Pharyngeal Arch Artery Morphogenesis
Protein-containing Complex Assembly
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Fatty Acid
Glomerulus Vasculature Development
Comma-shaped Body Morphogenesis
S-shaped Body Morphogenesis
Renal Interstitial Fibroblast Development
Metanephric Nephron Tubule Morphogenesis
Cochlea Development
Establishment Of Epithelial Cell Polarity
Negative Regulation Of Calcium Ion Import
Response To Thyroid Hormone
Vascular Associated Smooth Muscle Cell Development
Neuronal Stem Cell Population Maintenance
Negative Regulation Of Amacrine Cell Differentiation
Response To Aroclor 1254
Negative Regulation Of Cell Fate Determination
Cellular Response To Nerve Growth Factor Stimulus
Negative Regulation Of Pancreatic A Cell Differentiation
Negative Regulation Of Stem Cell Differentiation
Negative Regulation Of Pro-B Cell Differentiation
Negative Regulation Of Forebrain Neuron Differentiation
Negative Regulation Of Inner Ear Receptor Cell Differentiation
Pathways
Calmodulin induced events
Disinhibition of SNARE formation
SHC1 events in ERBB2 signaling
Signaling by SCF-KIT
Regulation of KIT signaling
EGFR Transactivation by Gastrin
Inactivation, recovery and regulation of the phototransduction cascade
Syndecan interactions
Acetylcholine regulates insulin secretion
Ca2+ pathway
Trafficking of GluR2-containing AMPA receptors
G alpha (z) signalling events
Depolymerization of the Nuclear Lamina
HuR (ELAVL1) binds and stabilizes mRNA
WNT5A-dependent internalization of FZD4
VEGFR2 mediated cell proliferation
RHO GTPases Activate NADPH Oxidases
Response to elevated platelet cytosolic Ca2+
RET signaling
ROBO receptors bind AKAP5
ROBO receptors bind AKAP5
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
RUNX2 regulates osteoblast differentiation
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Phosphatidyl serine
Vitamin E
Tamoxifen
Staurosporine
Dequalinium
Ingenol mebutate
Aprinocarsen
Midostaurin
Perifosine
Ellagic acid
Benzoyl peroxide
Bryostatin 1
alpha-Tocopherol succinate
D-alpha-Tocopherol acetate
Diseases
GWAS
Appendicular lean mass (
33097823
)
Bipolar disorder (
31043756
)
Body composition traits (
30026463
)
Brugada syndrome (
35210625
)
Cardiorespiratory fitness (800m run time) (
32572135
)
Carotid intima media thickness x smoking interaction (
32117412
)
Coronary artery calcification (
23870195
)
Cryptosporidiosis (
32019797
)
Daytime nap (
33568662
)
Dilated cardiomyopathy (MTAG) (
33495596
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic traits (multivariate) (
32602732
)
Feeling guilty (
29500382
)
Food addiction (
27106561
)
Gout (
22179738
)
Haemorrhoidal disease (
33888516
)
Height (
22021425
)
Heschl's gyrus morphology (
25130324
)
Hypertrophic cardiomyopathy (
33495596
33495597
)
Hypertrophic cardiomyopathy (MTAG) (
33495596
)
Hypertrophic cardiomyopathy (sarcomere negative) (
33495597
)
Lateral occipital cortex volume (
31530798
)
Neuroticism (
29255261
)
Percent glycated albumin (
29844224
)
Possible neuropathic pain in post total joint replacement surgery for osteoarthritis (
28051079
)
Post-traumatic stress disorder (asjusted for relatedness) (
23726511
)
PR interval (
32439900
)
QRS complex (12-leadsum) (
27659466
)
QRS complex (Sokolow-Lyon) (
27659466
)
QRS duration (
30012220
27577874
27659466
)
QT interval (
24952745
29213071
29874175
)
Systolic blood pressure (
31170924
)
Total glycated albumin levels (
29844224
)
Alcoholic chronic pancreatitis (
28754779
)
Dental caries (decayed, missing and filled teeth) (
31533690
)
Dental caries (decayed, missing and filled tooth surfaces) (
31533690
)
Thyroid stimulating hormone levels (
30367059
32769997
)
Interacting Genes
230 interacting genes:
ACTA1
ADAP1
ADCY5
ADD1
ADD3
ADRA1B
AFAP1
AKAP12
AKAP5
ANXA2
ANXA7
APLP2
ARHGEF1
ATP1A1
ATP2B1
ATP2B2
AVPR1A
BCL2
BTG2
BTK
C1QBP
CACYBP
CASR
CAVIN2
CBL
CD163
CD5
CD9
CDC42
CDKN2A
CFTR
CHAT
CISH
CORO1B
CREM
CYP3A4
CYTH2
DDX5
DGKD
DGKZ
DLG4
DLX3
DNM1
DVL2
EDF1
EEF1D
EGFR
EGLN2
EIF2S1
EIF4E
EIF4EBP1
ELAVL1
ENTPD5
EP300
EWSR1
EZR
F11R
FAS
FBXO25
FBXO7
FCGR2B
FCGR3A
FLNA
FLNC
FSCN1
GABRB3
GABRG2
GABRR1
GABRR2
GFAP
GFPT1
GJA1
GJB1
GLI3
GMFB
GNA12
GNA15
GPM6A
GRIA1
GRIA2
GRIA4
GRIN1
GRIN2A
GRIN2B
GRK2
GRM1
GRM5
GSK3A
GSK3B
H1-1
H1-2
H1-3
H1-4
H1-5
H1-6
H3-4
H3C1
HABP4
HAND1
HAND2
HES1
HLA-A
HMGA1
HMGA2
HMGB1
HMGN1
HMGN2
HR
HSP90AA1
HSPA1A
HSPB8
IKBKB
INSR
ITGB1
ITGB2
ITGB4
ITPKA
ITPKB
KCNE1
KCNE4
KCNQ2
KIT
KLF5
KRT18
LCK
LMNA
LMNB1
MAPKAP1
MAPT
MARCKS
MBP
MGMT
MTOR
MYLK
MYOD1
NCF1
NF2
NFATC1
NFE2L2
NFKBIA
NHERF1
NHERF2
NOS1
NOXA1
NR1H2
NRGN
NUMB
OGG1
OPRD1
PA2G4
PAM
PDLIM7
PEA15
PEBP1
PFKFB1
PFKFB2
PHB2
PICK1
PLA2G4A
PLCB1
PLD1
PLD2
POLB
PPARA
PPARG
PPM1A
PPP1R14A
PRKCZ
PRKG1
PSMB4
PTGIR
PTPN1
PTPN11
PTPN12
PTPN6
RAC1
RACK1
RAF1
RALBP1
RARA
RBCK1
RGS19
RGS2
RGS7
RHO
RHOA
RNF31
RPL10
RRAD
SACM1L
SCRIB
SCTR
SDC2
SDC4
SELL
SEMG1
SEMG2
SHC1
SLC1A1
SLC6A9
SMURF1
SNAP23
SNAP25
SPAG1
SPP1
SRC
STMN1
STXBP1
STXBP3
SYK
TBXA2R
TEP1
TERT
THOC5
TIAM1
TNNI3
TNNT2
TNP1
TNP2
TOP2A
TP53
TRIM29
TRIM41
TRPC3
TRPV6
VCL
VTN
XK
YWHAG
YWHAZ
36 interacting genes:
ALK
APCS
APH1A
ASGR2
CSNK1E
FANCA
FANCE
FANCF
FANCG
FANCL
FHL1
FOXG1
GAPDH
HDAC6
HES6
HEY2
HMGB1
HMGCL
ID1
ID2
ID3
ID4
JAK2
LTBR
NHLH2
NR4A1
NUDT3
PRKCA
PTK2
RUNX2
SIRT1
STAT3
TLE1
TLE2
UBQLN1
YWHAB
Entrez ID
5578
3280
HPRD ID
01498
00770
Ensembl ID
ENSG00000154229
ENSG00000114315
Uniprot IDs
J3KRN5
L7RSM7
P17252
Q7Z727
Q14469
PDB IDs
2ELI
3IW4
4DNL
4RA4
8U37
8UAK
2MH3
7C4O
Enriched GO Terms of Interacting Partners
?
Regulation Of Biological Quality
Regulation Of Transport
Regulation Of Signaling
Regulation Of Cell Communication
Plasma Membrane
Regulation Of Multicellular Organismal Process
Intracellular Signal Transduction
Positive Regulation Of Signaling
Signal Transduction
Positive Regulation Of Cell Communication
Regulation Of System Process
Regulation Of Developmental Process
Regulation Of Signal Transduction
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Signal Transduction
Intracellular Signaling Cassette
Positive Regulation Of Transport
Regulation Of Cell Differentiation
Regulation Of Cellular Component Organization
Regulation Of Intracellular Signal Transduction
Developmental Process
Positive Regulation Of Multicellular Organismal Process
Negative Regulation Of Cell Communication
Regulation Of Cell Development
Regulation Of Membrane Potential
Cellular Developmental Process
Regulation Of Programmed Cell Death
Negative Regulation Of Signaling
Calmodulin Binding
Focal Adhesion
Regulation Of Apoptotic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Synaptic Plasticity
Regulation Of Blood Circulation
Cytosol
Negative Regulation Of Signal Transduction
Positive Regulation Of Developmental Process
Modulation Of Chemical Synaptic Transmission
Positive Regulation Of Metabolic Process
Regulation Of Protein Localization
Regulation Of Multicellular Organismal Development
Regulation Of Vesicle-mediated Transport
Protein Kinase Binding
Regulation Of Protein Metabolic Process
Cell Differentiation
Glutamatergic Synapse
Cytoplasm
Negative Regulation Of Programmed Cell Death
Regulation Of Metabolic Process
Dendritic Spine
Fanconi Anaemia Nuclear Complex
Regulation Of Cell Differentiation
Transcription Regulator Inhibitor Activity
Nucleus
Protein Dimerization Activity
Transcription Corepressor Activity
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cell Population Proliferation
Interstrand Cross-link Repair
Animal Organ Development
Negative Regulation Of RNA Metabolic Process
Regulation Of Cell Population Proliferation
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Cell Differentiation
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Biosynthetic Process
Chromatin
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Cellular Developmental Process
Developmental Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Epithelial Cell Proliferation
Nucleoplasm
Cell Differentiation
Regulation Of Developmental Process
Circadian Rhythm
Regulation Of Primary Metabolic Process
Regulation Of Multicellular Organismal Development
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Development
Transcription Regulator Complex
Neuron Differentiation
Rhythmic Process
Animal Organ Morphogenesis
Positive Regulation Of Cell Differentiation
Positive Regulation Of Developmental Process
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of Signal Transduction
Negative Regulation Of Developmental Process
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Apoptotic Process
Response To Stress
Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Gene Expression
Anatomical Structure Morphogenesis
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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