PRKCA and PEBP1

Number of citations of the paper that reports this interaction (PMID 12551925)
66

Data Source:
HPRD (in vivo, in vitro)

		PRKCA	PEBP1
Gene Name		protein kinase C, alpha	phosphatidylethanolamine binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Dendrite Mitochondrial Membrane Neuronal Cell Body Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleus Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Zinc Ion Binding Enzyme Binding Histone Kinase Activity (H3-T6 Specific)	Serine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Phosphatidylethanolamine Binding Enzyme Binding Protein Kinase Binding Poly(A) RNA Binding
	Biological Process	Inactivation Of MAPK Activity Mitotic Cell Cycle Angiogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Regulation Of The Force Of Heart Contraction Chondrocyte Differentiation Desmosome Assembly Energy Reserve Metabolic Process Protein Phosphorylation Cellular Calcium Ion Homeostasis Regulation Of Muscle Contraction Mitotic Nuclear Envelope Disassembly Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Negative Regulation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Synaptic Transmission Blood Coagulation Phototransduction, Visible Light Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Platelet Activation Extracellular Matrix Organization Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Histone H3-T6 Phosphorylation Peptidyl-serine Autophosphorylation Positive Regulation Of Blood Vessel Endothelial Cell Migration Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Inflammatory Response Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Insulin Secretion Induction Of Positive Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Cellular Response To Carbohydrate Stimulus Regulation Of Platelet Aggregation Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Dense Core Granule Biogenesis	Negative Regulation Of Endopeptidase Activity
Pathways		Ca-dependent events Signaling by GPCR CaM pathway Signaling by FGFR in disease Phospholipase C-mediated cascade Integration of energy metabolism Mitotic Prophase Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Regulation of KIT signaling Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ G alpha (z) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Signaling by PDGF Calmodulin induced events DAP12 interactions Regulation of mRNA stability by proteins that bind AU-rich elements Opioid Signalling Diseases associated with visual transduction EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR Syndecan interactions GPCR downstream signaling Signaling by VEGF Calmodulin induced events Downstream signal transduction WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer Platelet activation, signaling and aggregation PCP/CE pathway Transmission across Chemical Synapses Trafficking of GluR2-containing AMPA receptors Nuclear Envelope Breakdown HuR stabilizes mRNA DAG and IP3 signaling M Phase VEGFA-VEGFR2 Pathway CaM pathway Inactivation, recovery and regulation of the phototransduction cascade EGFR Transactivation by Gastrin VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR The phototransduction cascade Disinhibition of SNARE formation Innate Immune System Signalling by NGF PLC beta mediated events Regulation of insulin secretion Depolymerisation of the Nuclear Lamina Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Non-integrin membrane-ECM interactions Signaling by Overexpressed Wild-Type EGFR in Cancer Trafficking of AMPA receptors Cell Cycle, Mitotic Signaling by FGFR beta-catenin independent WNT signaling Acetylcholine regulates insulin secretion Visual phototransduction Ca2+ pathway PLC-gamma1 signalling Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
Drugs		Phosphatidylserine Vitamin E Ingenol Mebutate Ellagic Acid
Diseases
GWAS		Height ( 22021425) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Ventricular conduction ( 21076409)
Protein-Protein Interactions		210 interactors: ACTA1 ADAP1 ADCY5 ADD3 ADRA1B ADRBK1 AFAP1 AKAP12 AKAP5 ANXA2 ANXA7 APLP2 ARHGEF1 ATP1A1 ATP2B1 ATP2B2 AVPR1A BCL2 BTG2 BTK C1QBP CASR CBL CD163 CD5 CD9 CDC42 CDKN2A CFTR CHAT CISH CORO1B CREM CYP3A4 CYTH2 DDX5 DGKD DGKZ DLG4 DLX3 DNM1 DVL2 EDF1 EEF1D EGFR EIF4E EIF4EBP1 ELAVL1 ENTPD5 EP300 EWSR1 EZR F11R FAS FBXO25 FLNA FLNC FSCN1 GABRB3 GABRG2 GABRR1 GABRR2 GFAP GFPT1 GJA1 GJB1 GLI3 GMFB GNA12 GNA15 GNB2L1 GPM6A GRIA1 GRIA2 GRIA4 GRIN1 GRIN2A GRIN2B GRM1 GRM5 GSK3A GSK3B HABP4 HAND1 HAND2 HES1 HIST1H1A HIST1H1B HIST1H1C HIST1H1D HIST1H1E HIST1H1T HIST1H3A HIST3H3 HLA-A HMGA1 HMGA2 HMGB1 HMGN1 HMGN2 HSP90AA1 HSPA1A HSPB8 IKBKB INSR ITGB1 ITGB2 ITGB4 ITPKA ITPKB KCNE1 KCNE4 KCNQ2 KIT KLF5 KRT18 LCK LMNA LMNB1 MARCKS MBP MGMT MTOR MYLK MYOD1 NCF1 NFATC1 NFE2L2 NFKBIA NOS1 NR1H2 NRGN NUMB OGG1 OPRD1 PA2G4 PAM PDLIM7 PEA15 PEBP1 PFKFB1 PFKFB2 PICK1 PLCB1 PLD1 PLD2 POLB PPARA PPARG PPP1R14A PRKCZ PRKG1 PSMB4 PTGIR PTPN11 PTPN12 PTPN6 RAC1 RAF1 RALBP1 RARA RBCK1 RGS19 RGS2 RGS7 RHO RHOA RNF31 RPL10 RRAD SACM1L SCRIB SCTR SDC2 SDC4 SDPR SELL SEMG1 SEMG2 SHC1 SLC1A1 SLC6A9 SNAP23 SNAP25 SPAG1 SPP1 SRC STXBP1 STXBP3 SYK TBXA2R TEP1 TERT THOC5 TIAM1 TNNI3 TNNT2 TNP1 TNP2 TOP2A TP53 TRIM29 TRIM41 TRPC3 TRPV6 VCL VTN XK YWHAG YWHAZ	20 interactors: ADRBK1 CACHD1 CHUK GSDMB IKBKB MAP2K1 MAP3K14 MAP3K7 MAPK1 MED10 NKX3-1 NR2C2 PPARD PRKCA PRKCB PRKCD PRKCG PRKCZ RAF1 STC2
Entrez ID		5578	5037
HPRD ID		01498	06850
Ensembl ID		ENSG00000154229	ENSG00000089220
Uniprot IDs		P17252 Q7Z727	B4DRT4 D9IAI1 P30086
PDB IDs		2ELI 3IW4 4DNL	1BD9 1BEH 2L7W 2QYQ
Enriched GO Terms of Interacting Partners?		Response To Stimulus Cellular Response To Stimulus Regulation Of Signaling Signaling Cell Communication Developmental Process Response To Organic Substance Positive Regulation Of Metabolic Process Response To Stress Multicellular Organismal Development Response To Wounding Cell Differentiation Anatomical Structure Development Regulation Of Cellular Process Signal Transduction Wound Healing Regulation Of Signal Transduction Hemostasis Positive Regulation Of Cellular Metabolic Process Response To External Stimulus Blood Coagulation Regulation Of Body Fluid Levels System Development Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Locomotion Response To Organonitrogen Compound Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Cell Development Regulation Of Catalytic Activity Positive Regulation Of Transport Regulation Of Metabolic Process Response To Abiotic Stimulus Movement Of Cell Or Subcellular Component Regulation Of Protein Metabolic Process Regulation Of Cellular Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Neurogenesis Nervous System Development Organ Development Generation Of Neurons Cell-cell Signaling Intracellular Signal Transduction Regulation Of Cell Differentiation Response To Organic Cyclic Compound Platelet Activation Regulation Of Cellular Protein Metabolic Process	Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Protein Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Fibroblast Growth Factor Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Phosphorylation Intracellular Signal Transduction Platelet Activation Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptidyl-threonine Phosphorylation Positive Regulation Of Immune System Process Toll-like Receptor 5 Signaling Pathway Regulation Of Signal Transduction Response To Stress Immune Response Regulation Of Immune System Process Toll-like Receptor 10 Signaling Pathway Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Defense Response Phosphate-containing Compound Metabolic Process Toll-like Receptor 2 Signaling Pathway Fc Receptor Signaling Pathway Toll-like Receptor 9 Signaling Pathway Response To Wounding Immune Response-regulating Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Protein Kinase Activity Activation Of MAPKK Activity MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Toll-like Receptor 3 Signaling Pathway Regulation Of Signaling
Tagcloud ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig rara representatives sheep southern swine synteny tk1 umph2	aspects bio blotting cytoskeleton differentially dimensional downregulated downregulation electrophoresis eleven elucidate expressions gastric gastritis gel matched mucosa neuropolypeptide oxidation phosphatidylethanolamine preliminarily rt ten thioredoxin txndc5 upregulated upregulation validated varioliform
Tagcloud (Difference) ?		american artiodactyla assigned block blot cattle chr conservative conserved cow erbb2 hybrid hybridization localization localized means mink nf1 pepa pig rara representatives sheep southern swine synteny tk1 umph2	aspects bio blotting cytoskeleton differentially dimensional downregulated downregulation eleven elucidate expressions gastric gastritis gel matched mucosa neuropolypeptide oxidation phosphatidylethanolamine preliminarily rt ten thioredoxin txndc5 upregulated upregulation validated varioliform
Tagcloud (Intersection) ?		electrophoresis