PRKACB and APPBP2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PRKACB	APPBP2
Gene Name		protein kinase, cAMP-dependent, catalytic, beta	amyloid beta precursor protein (cytoplasmic tail) binding protein 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Ciliary Base	Nucleus Cytoplasm Microtubule Microtubule Associated Complex Cytoplasmic Vesicle Membrane
	Molecular Function	Magnesium Ion Binding CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding	Microtubule Motor Activity Protein Binding
	Biological Process	Neural Tube Closure Renal Water Homeostasis Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Energy Reserve Metabolic Process Protein Phosphorylation Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Synaptic Transmission Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Pathogenesis Triglyceride Catabolic Process Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Negative Regulation Of Meiotic Cell Cycle Transmembrane Transport Regulation Of Protein Processing Cellular Response To Glucagon Stimulus Response To Clozapine Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning	Intracellular Protein Transport Metabolic Process Intracellular Transport
Pathways		Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Metabolism of lipids and lipoproteins Integration of energy metabolism Hedgehog 'off' state Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Gluconeogenesis Glucose metabolism DAP12 signaling Rap1 signalling Myoclonic epilepsy of Lafora Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis Glycogen storage diseases PKA-mediated phosphorylation of key metabolic factors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Aquaporin-mediated transport Factors involved in megakaryocyte development and platelet production CREB phosphorylation through the activation of Adenylate Cyclase EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR PKA-mediated phosphorylation of CREB Signaling by VEGF Downstream signal transduction Calmodulin induced events Signaling by EGFR in Cancer PKA activation Metabolism of carbohydrates Transmission across Chemical Synapses Adaptive Immune System VEGFA-VEGFR2 Pathway DAG and IP3 signaling CaM pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events Downstream signaling of activated FGFR DARPP-32 events Post NMDA receptor activation events Innate Immune System PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer Lipid digestion, mobilization, and transport NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR PLC-gamma1 signalling Signaling by Hedgehog Degradation of GLI1 by the proteasome GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS		Breast cancer (male) ( 23001122)
Protein-Protein Interactions		12 interactors: ACVR1B APPBP2 ARFGAP1 CSNK2A1 NGFR PKIA PKIB RPL27A RPS6 SPP1 TNP1 TNP2	79 interactors: AHCY AIM2 AK3 ANKRD10 APP AR ARMCX5 C1orf50 C6orf226 CALM3 CCDC85C CCNL1 CDK16 CHMP5 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CTC1 DCD DHRS2 DPEP1 EID3 EPT1 ERO1L FAM19A4 FAM92A1 FSTL1 FXYD7 GALNT3 GCSAM GP9 GSTP1 HIPK4 HIST1H2AK HSPA4 KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MFSD3 MGC34796 MLLT3 MUL1 NFYA NPRL3 PCSK5 PI4KAP2 PPP1R8 PRKAA2 PRKACB PYROXD2 RASSF5 RNF128 RNF34 RRS1 SELV SLC22A6 SLC25A23 SNX5 ST8SIA5 SYNRG SYT11 TAF11 TBL3 TCF25 UBE2R2 UGGT2 WAS WDR24 WNT5B ZC3H10 ZCCHC12 ZNF747
Entrez ID		5567	10513
HPRD ID		01482	05616
Ensembl ID		ENSG00000142875	ENSG00000062725
Uniprot IDs		B1APF9 B1APG3 B2RB89 B7ZA00 P22694	Q92624
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of CAMP-dependent Protein Kinase Activity Intracellular Protein Transport Protein Complex Disassembly Establishment Of Localization In Cell Locomotion Reproductive Process Cellular Protein Localization Developmental Process Involved In Reproduction Regulation Of Protein Metabolic Process Sperm Motility Protein Transport Negative Regulation Of Axonogenesis Establishment Of Protein Localization Movement Of Cell Or Subcellular Component Multicellular Organismal Reproductive Process Fertilization, Exchange Of Chromosomal Proteins Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Intracellular Transport Cellular Localization Multicellular Organism Reproduction Regulation Of Cell Growth Regulation Of Cell Cycle Viral Transcription Regulation Of Mitotic Cell Cycle Hair Follicle Development Male Pronucleus Assembly Positive Regulation Of Trophoblast Cell Migration Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Apoptotic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Hair Cycle Process SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Negative Regulation Of Cell Morphogenesis Involved In Differentiation Programmed Cell Death Establishment Of Protein Localization To Endoplasmic Reticulum Negative Regulation Of Cell Cycle Hair Cycle Reproduction Cell Death Death Regulation Of Protein Phosphorylation Negative Regulation Of Hair Follicle Development Protein Localization Negative Regulation Of Neuron Projection Development Protein Localization To Endoplasmic Reticulum Regulation Of Cellular Protein Metabolic Process Single Fertilization	Regulation Of Defense Response To Virus By Host Response To Stress Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Homocysteine Metabolic Process Cellular Response To Organic Substance
Tagcloud ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkar1a prkar2a proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	10kb arhgap32 bcas3 breakpoints ccdc49 coamplification col14a1 coregulator ddx5 depdc6 deptor enpp2 hoxb9 lasp1 leukaemias nrip1 oprd1 painting pcgf2 phf20l1 plec1 skap1 taok1 tiam1 timm23 trps1 unamplified usp32 zmym4
Tagcloud (Difference) ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkar1a prkar2a proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	10kb arhgap32 bcas3 breakpoints ccdc49 coamplification col14a1 coregulator ddx5 depdc6 deptor enpp2 hoxb9 lasp1 leukaemias nrip1 oprd1 painting pcgf2 phf20l1 plec1 skap1 taok1 tiam1 timm23 trps1 unamplified usp32 zmym4
Tagcloud (Intersection) ?