PRKACB and AVPI1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRKACB	AVPI1
Description		protein kinase cAMP-activated catalytic subunit beta	arginine vasopressin induced 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane Extracellular Exosome Ciliary Base
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Ubiquitin Protein Ligase Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Neural Tube Closure Renal Water Homeostasis Protein Phosphorylation Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cellular Response To Nutrient Levels High-density Lipoprotein Particle Assembly TORC1 Signaling Negative Regulation Of Smoothened Signaling Pathway Regulation Of Protein Processing Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Negative Regulation Of TORC1 Signaling	Positive Regulation Of MAPK Cascade
Pathways		PKA-mediated phosphorylation of CREB PKA-mediated phosphorylation of key metabolic factors Triglyceride catabolism PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins VEGFA-VEGFR2 Pathway CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of Adenylate Cyclase Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state CD209 (DC-SIGN) signaling MAPK6/MAPK4 signaling RET signaling HDL assembly ROBO receptors bind AKAP5 GPER1 signaling GPER1 signaling Regulation of glycolysis by fructose 2,6-bisphosphate metabolism ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Phosphonothreonine Fostamatinib
Diseases
GWAS		Breast cancer (male) ( 23001122) Femur bone mineral density x serum urate levels interaction ( 34046847) Metabolite levels ( 23823483)
Interacting Genes		15 interacting genes: ACVR1B APPBP2 ARFGAP1 AVPI1 CSNK2A1 FBXO7 NGFR PKIA PKIB RPL27A RPS6 SPP1 TNP1 TNP2 TP73	34 interacting genes: AIRIM APP CABP2 CDCA7L CYSRT1 DGCR6L EMD ENKD1 GOLGA6L9 IKBKG KRT31 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP4-2 LMO3 LONRF1 MDFI MKRN3 PHF1 PICK1 POLR1C PPP1R16A PRKAA2 PRKACA PRKACB RIPPLY1 RIPPLY2 SCNM1
Entrez ID		5567	60370
HPRD ID		01482	16530
Ensembl ID		ENSG00000142875	ENSG00000119986
Uniprot IDs		A0A087WVC4 B1APF9 B1APG3 B2RB89 B7ZA00 P22694	Q5T686
PDB IDs
Enriched GO Terms of Interacting Partners?		CAMP-dependent Protein Kinase Inhibitor Activity Positive Regulation Of Metabolic Process Regulation Of Cell Communication Negative Regulation Of Growth Hair Follicle Development Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway Negative Regulation Of CAMP-dependent Protein Kinase Activity Protein Kinase Inhibitor Activity Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of Protein Processing Sperm DNA Condensation Sperm DNA Decondensation Positive Regulation Of Protein Maturation Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Developmental Process Regulation Of Protein Processing	Keratin Filament Intermediate Filament Protein Localization To Lipid Droplet Cytosol CAMP-dependent Protein Kinase Activity Regulation Of Glycolytic Process CAMP-dependent Protein Kinase Complex Ciliary Base High-density Lipoprotein Particle Assembly Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Somite Rostral/caudal Axis Specification Nucleotide-activated Protein Kinase Complex Regulation Of Carbohydrate Catabolic Process Negative Regulation Of TORC1 Signaling TORC1 Signaling Vascular Endothelial Cell Response To Fluid Shear Stress Regulation Of ATP Metabolic Process Axis Specification Regulation Of Purine Nucleotide Metabolic Process TOR Signaling Cellular Response To Laminar Fluid Shear Stress Renal Water Homeostasis Positive Regulation Of Protein Export From Nucleus Negative Regulation Of TOR Signaling Positive Regulation Of Glycolytic Process Response To Laminar Fluid Shear Stress Plasma Lipoprotein Particle Assembly Regulation Of TORC1 Signaling Protein-lipid Complex Assembly Positive Regulation Of Receptor Internalization Protein Serine/threonine/tyrosine Kinase Activity Multicellular Organismal-level Water Homeostasis Amyloid Fibril Formation Cellular Response To Nutrient Levels Embryonic Axis Specification Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Identical Protein Binding TMEM240-body Cellular Response To Fluid Shear Stress Negative Regulation Of Signaling Negative Regulation Of Cell Communication
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