APPBP2 and AADAC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APPBP2	AADAC
Description		amyloid beta precursor protein binding protein 2	arylacetamide deacetylase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Membrane Cytoplasmic Vesicle Membrane Cul2-RING Ubiquitin Ligase Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Microtubule Motor Activity Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Catalytic Activity Triacylglycerol Lipase Activity Protein Binding Lipase Activity Hydrolase Activity Serine Hydrolase Activity Deacetylase Activity Carboxylic Ester Hydrolase Activity
	Biological Process	Intracellular Protein Transport Protein Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Transport	Lipid Metabolic Process Xenobiotic Metabolic Process Positive Regulation Of Triglyceride Catabolic Process
Pathways			Phase I - Functionalization of compounds
Drugs
Diseases
GWAS		Interleukin-6 levels ( 33517400) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-hip ratio ( 28552196)	Immunoglobulin A ( 20694011) Male-pattern baldness ( 28196072 29146897)
Interacting Genes		122 interacting genes: - AADAC ACTN1 AHCY AIM2 AK3 ALDH1L1 ANKRD10 APP AR ARMCX5 ASCC3 ATP13A1 BCL7A BIN2 C1orf50 CALM3 CCDC167 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CST2 CTC1 CYBA DCD DHRS2 DHX16 DOLK DPEP1 DPYS EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GPRC5C GSTP1 H2AC15 HGFAC HIPK4 HSD3B7 HSPA4 ITGB4 ITGB5 KHK KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MAN2B2 MCOLN1 MGAT4B MLLT3 MMP28 MRPL28 MSH2 MSLN MUL1 MYLK NFYA NHERF1 NPRL3 PCSK5 PEX39 PI4KAP2 PNPLA5 PPIL6 PPP1R8 PRKAA2 PRKACB PSAP PTCH1 PYROXD2 RAB7B RASSF5 RHEB RILPL1 RNF128 RNF34 RNGTT RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SLC33A2 SLC7A10 SNX5 SPDYE2 SPDYE2B ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 TNP2 TRMT2A UBE2R2 UGGT2 WAS WDR24 WFIKKN1 WNT5B ZC3H10 ZCCHC12 ZNF747	1 interacting genes: APPBP2
Entrez ID		10513	13
HPRD ID		05616	02640
Ensembl ID		ENSG00000062725	ENSG00000114771
Uniprot IDs		Q92624	P22760
PDB IDs		8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV
Enriched GO Terms of Interacting Partners?		Protein Binding	Filopodium Tip Optic Nerve Morphogenesis Regulation Of Skeletal Muscle Cell Proliferation Transmembrane-ephrin Receptor Activity Negative Regulation Of Skeletal Muscle Cell Differentiation Negative Regulation Of Skeletal Muscle Cell Proliferation Cell Migration In Hindbrain Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Axon Guidance Receptor Activity Negative Regulation Of Satellite Cell Differentiation Immunological Synapse Formation Cranial Nerve Morphogenesis Hindbrain Tangential Cell Migration Dendritic Spine Development Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Dendritic Spine Morphogenesis Regulation Of Skeletal Muscle Satellite Cell Proliferation Ephrin Receptor Activity Skeletal Muscle Satellite Cell Activation Cul2-RING Ubiquitin Ligase Complex Detection Of Temperature Stimulus Involved In Sensory Perception Retinal Ganglion Cell Axon Guidance Detection Of Temperature Stimulus Regulation Of Skeletal Muscle Cell Differentiation Central Nervous System Projection Neuron Axonogenesis Camera-type Eye Morphogenesis Dendritic Spine Organization Cranial Nerve Development Central Nervous System Neuron Axonogenesis Microtubule Associated Complex Neuron Projection Organization Postsynapse Organization Nerve Development Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Signaling Pathway Positive Regulation Of Synapse Assembly Eye Morphogenesis Cell-cell Recognition Microtubule Motor Activity Sensory Organ Morphogenesis Protein Modification Process Establishment Of Cell Polarity Neural Precursor Cell Proliferation
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