APPBP2 and SLC7A10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APPBP2	SLC7A10
Description		amyloid beta precursor protein binding protein 2	solute carrier family 7 member 10
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Membrane Cytoplasmic Vesicle Membrane Cul2-RING Ubiquitin Ligase Complex	Plasma Membrane Membrane
	Molecular Function	Microtubule Motor Activity Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding Organic Cation Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity L-serine Transmembrane Transporter Activity Transmembrane Transporter Activity
	Biological Process	Intracellular Protein Transport Protein Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Transport	Amino Acid Transport Neutral Amino Acid Transport Glycine Transport L-serine Transport D-alanine Transmembrane Transport D-serine Transmembrane Transport Transmembrane Transport Positive Regulation Of Synaptic Transmission, Glycinergic L-alpha-amino Acid Transmembrane Transport Negative Regulation Of Brown Fat Cell Differentiation
Pathways			Basigin interactions Amino acid transport across the plasma membrane
Drugs
Diseases
GWAS		Interleukin-6 levels ( 33517400) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-hip ratio ( 28552196)	Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184) Asthma ( 34103634 30929738 32296059 31959851 31361310 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Eosinophil count ( 32888494) Mastocytosis (KIT D816V positive) ( 33421400) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Multiple sclerosis ( 31604244) Red blood cell count ( 29403010) Triglyceride levels ( 32203549) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) White blood cell count (basophil) ( 29403010)
Interacting Genes		122 interacting genes: - AADAC ACTN1 AHCY AIM2 AK3 ALDH1L1 ANKRD10 APP AR ARMCX5 ASCC3 ATP13A1 BCL7A BIN2 C1orf50 CALM3 CCDC167 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CST2 CTC1 CYBA DCD DHRS2 DHX16 DOLK DPEP1 DPYS EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GPRC5C GSTP1 H2AC15 HGFAC HIPK4 HSD3B7 HSPA4 ITGB4 ITGB5 KHK KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MAN2B2 MCOLN1 MGAT4B MLLT3 MMP28 MRPL28 MSH2 MSLN MUL1 MYLK NFYA NHERF1 NPRL3 PCSK5 PEX39 PI4KAP2 PNPLA5 PPIL6 PPP1R8 PRKAA2 PRKACB PSAP PTCH1 PYROXD2 RAB7B RASSF5 RHEB RILPL1 RNF128 RNF34 RNGTT RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SLC33A2 SLC7A10 SNX5 SPDYE2 SPDYE2B ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 TNP2 TRMT2A UBE2R2 UGGT2 WAS WDR24 WFIKKN1 WNT5B ZC3H10 ZCCHC12 ZNF747	3 interacting genes: APPBP2 CFTR SLC3A2
Entrez ID		10513	56301
HPRD ID		05616	12137
Ensembl ID		ENSG00000062725	ENSG00000130876
Uniprot IDs		Q92624	K7EK24 Q9NS82
PDB IDs		8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV	8QEY 8WNS 8WNT 8WNY
Enriched GO Terms of Interacting Partners?		Protein Binding	Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Basolateral Plasma Membrane Apical Pole Of Neuron Isoleucine Transport L-histidine Transport Exogenous Protein Binding Methionine Transport L-leucine Transmembrane Transporter Activity L-leucine Import Across Plasma Membrane Phenylalanine Transport Amino Acid Transport Complex L-alanine Transmembrane Transport Aromatic Amino Acid Transmembrane Transporter Activity Valine Transport Tryptophan Transport L-alanine Import Across Plasma Membrane Tyrosine Transport Positive Regulation Of Tooth Mineralization L-alanine Transmembrane Transporter Activity Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation L-alanine Transport Amelogenesis L-leucine Transport Proline Transport Organic Anion Transport ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Aromatic Amino Acid Transport Branched-chain Amino Acid Transport Thyroid Hormone Transport Apical Plasma Membrane Lysosomal Membrane Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Alanine Transport Sulfur Amino Acid Transport Cellular Response To Forskolin Response To Forskolin
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