APPBP2 and RAB7B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APPBP2	RAB7B
Description		amyloid beta precursor protein binding protein 2	RAB7B, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Membrane Cytoplasmic Vesicle Membrane Cul2-RING Ubiquitin Ligase Complex	Lysosome Endosome Late Endosome Golgi Apparatus Trans-Golgi Network Membrane Phagocytic Vesicle Membrane Organelle Membrane Cytoplasmic Vesicle Late Endosome Membrane Phagocytic Vesicle
	Molecular Function	Microtubule Motor Activity Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding
	Biological Process	Intracellular Protein Transport Protein Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Transport	Regulation Of Immune System Process Endosome To Lysosome Transport Protein Transport Positive Regulation Of Interleukin-6 Production Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Late Endosome To Golgi Transport Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Type II Interferon Phagosome-lysosome Fusion
Pathways			TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Interleukin-6 levels ( 33517400) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-hip ratio ( 28552196)
Interacting Genes		122 interacting genes: - AADAC ACTN1 AHCY AIM2 AK3 ALDH1L1 ANKRD10 APP AR ARMCX5 ASCC3 ATP13A1 BCL7A BIN2 C1orf50 CALM3 CCDC167 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CST2 CTC1 CYBA DCD DHRS2 DHX16 DOLK DPEP1 DPYS EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GPRC5C GSTP1 H2AC15 HGFAC HIPK4 HSD3B7 HSPA4 ITGB4 ITGB5 KHK KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MAN2B2 MCOLN1 MGAT4B MLLT3 MMP28 MRPL28 MSH2 MSLN MUL1 MYLK NFYA NHERF1 NPRL3 PCSK5 PEX39 PI4KAP2 PNPLA5 PPIL6 PPP1R8 PRKAA2 PRKACB PSAP PTCH1 PYROXD2 RAB7B RASSF5 RHEB RILPL1 RNF128 RNF34 RNGTT RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SLC33A2 SLC7A10 SNX5 SPDYE2 SPDYE2B ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 TNP2 TRMT2A UBE2R2 UGGT2 WAS WDR24 WFIKKN1 WNT5B ZC3H10 ZCCHC12 ZNF747	3 interacting genes: APP APPBP2 RAP1B
Entrez ID		10513	338382
HPRD ID		05616	15202
Ensembl ID		ENSG00000062725	ENSG00000276600
Uniprot IDs		Q92624	A0A096LP44 Q96AH8
PDB IDs		8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV
Enriched GO Terms of Interacting Partners?		Protein Binding	Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Response To CAMP Acetylcholine Receptor Activator Activity Membrane Raft PTB Domain Binding Response To Purine-containing Compound Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Junction Assembly Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of ERK1 And ERK2 Cascade Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Establishment Of Localization In Cell Synapse Organization Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Negative Regulation Of Synaptic Vesicle Exocytosis Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Calcium Ion-dependent Exocytosis Rap Protein Signal Transduction Antifungal Humoral Response Nuclear Envelope Lumen
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