APPBP2 and -

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		APPBP2	-
Description		amyloid beta precursor protein binding protein 2	sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) pseudogene
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Membrane Cytoplasmic Vesicle Membrane Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	Microtubule Motor Activity Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Intracellular Protein Transport Protein Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Transport
Pathways
Drugs
Diseases
GWAS		Interleukin-6 levels ( 33517400) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-hip ratio ( 28552196)	HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
Interacting Genes		122 interacting genes: - AADAC ACTN1 AHCY AIM2 AK3 ALDH1L1 ANKRD10 APP AR ARMCX5 ASCC3 ATP13A1 BCL7A BIN2 C1orf50 CALM3 CCDC167 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CST2 CTC1 CYBA DCD DHRS2 DHX16 DOLK DPEP1 DPYS EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GPRC5C GSTP1 H2AC15 HGFAC HIPK4 HSD3B7 HSPA4 ITGB4 ITGB5 KHK KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MAN2B2 MCOLN1 MGAT4B MLLT3 MMP28 MRPL28 MSH2 MSLN MUL1 MYLK NFYA NHERF1 NPRL3 PCSK5 PEX39 PI4KAP2 PNPLA5 PPIL6 PPP1R8 PRKAA2 PRKACB PSAP PTCH1 PYROXD2 RAB7B RASSF5 RHEB RILPL1 RNF128 RNF34 RNGTT RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SLC33A2 SLC7A10 SNX5 SPDYE2 SPDYE2B ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 TNP2 TRMT2A UBE2R2 UGGT2 WAS WDR24 WFIKKN1 WNT5B ZC3H10 ZCCHC12 ZNF747	2 interacting genes: APPBP2 CDKN2A
Entrez ID		10513	414927
HPRD ID		05616
Ensembl ID		ENSG00000062725
Uniprot IDs		Q92624
PDB IDs		8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV
Enriched GO Terms of Interacting Partners?		Protein Binding	Negative Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Macrophage Apoptotic Process Nuclear Body Organization Mitochondrial Depolarization Oncogene-induced Cell Senescence Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Protein Modification By Small Protein Conjugation Protein Ubiquitination Negative Regulation Of Protein Neddylation Positive Regulation Of Apoptotic Process Involved In Development Ubiquitin-protein Transferase Inhibitor Activity Somatic Stem Cell Division Negative Regulation Of Immature T Cell Proliferation Protein Localization To Nucleolus Negative Regulation Of Cyclin-dependent Protein Kinase Activity Positive Regulation Of Apoptotic Process Involved In Morphogenesis MDM2/MDM4 Family Protein Binding Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Replicative Senescence Ubiquitin Ligase Inhibitor Activity Regulation Of Immature T Cell Proliferation In Thymus Mammary Gland Epithelial Cell Proliferation Senescence-associated Heterochromatin Focus Positive Regulation Of Smooth Muscle Cell Apoptotic Process Ligase Inhibitor Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of B Cell Proliferation Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Apoptotic Process Involved In Mammary Gland Involution Positive Regulation Of Protein Sumoylation Cul2-RING Ubiquitin Ligase Complex SUMO Transferase Activity Post-translational Protein Modification Regulation Of Protein Neddylation Stem Cell Division Regulation Of T Cell Differentiation In Thymus Regulation Of Protein Sumoylation RRNA Transcription Apoptotic Process Involved In Morphogenesis Disordered Domain Specific Binding Regulation Of Ubiquitin-protein Transferase Activity Keratinocyte Proliferation Amyloid Fibril Formation Apoptotic Process Involved In Development
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