APPBP2 and SNX5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		APPBP2	SNX5
Description		amyloid beta precursor protein binding protein 2	sorting nexin 5
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Membrane Cytoplasmic Vesicle Membrane Cul2-RING Ubiquitin Ligase Complex	Ruffle Phagocytic Cup Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Brush Border Cytoplasmic Side Of Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Retromer Complex Retromer, Tubulation Complex Cytoplasmic Vesicle Early Endosome Membrane Cell Projection Perinuclear Region Of Cytoplasm Macropinocytic Cup Tubular Endosome Cytoplasmic Side Of Early Endosome Membrane
	Molecular Function	Microtubule Motor Activity Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding Lipid Binding Phosphatidylinositol-5-phosphate Binding D1 Dopamine Receptor Binding Dynactin Binding Phosphatidylinositol Binding Cadherin Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Intracellular Protein Transport Protein Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Transport	Intracellular Protein Transport Endocytosis Pinocytosis Epidermal Growth Factor Catabolic Process Protein Transport Regulation Of Macroautophagy Retrograde Transport, Endosome To Golgi Negative Regulation Of Blood Pressure Positive Regulation Of DNA-templated Transcription Positive Regulation Of Insulin Receptor Signaling Pathway
Pathways			Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Interleukin-6 levels ( 33517400) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-hip ratio ( 28552196)	Apolipoprotein B levels ( 32203549) Cholesterol, total ( 25961943) LDL cholesterol ( 24097068 25961943) LDL cholesterol levels ( 28334899 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alanine transaminase) ( 33972514) Low density lipoprotein cholesterol levels ( 33339817)
Interacting Genes		122 interacting genes: - AADAC ACTN1 AHCY AIM2 AK3 ALDH1L1 ANKRD10 APP AR ARMCX5 ASCC3 ATP13A1 BCL7A BIN2 C1orf50 CALM3 CCDC167 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CST2 CTC1 CYBA DCD DHRS2 DHX16 DOLK DPEP1 DPYS EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GPRC5C GSTP1 H2AC15 HGFAC HIPK4 HSD3B7 HSPA4 ITGB4 ITGB5 KHK KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MAN2B2 MCOLN1 MGAT4B MLLT3 MMP28 MRPL28 MSH2 MSLN MUL1 MYLK NFYA NHERF1 NPRL3 PCSK5 PEX39 PI4KAP2 PNPLA5 PPIL6 PPP1R8 PRKAA2 PRKACB PSAP PTCH1 PYROXD2 RAB7B RASSF5 RHEB RILPL1 RNF128 RNF34 RNGTT RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SLC33A2 SLC7A10 SNX5 SPDYE2 SPDYE2B ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 TNP2 TRMT2A UBE2R2 UGGT2 WAS WDR24 WFIKKN1 WNT5B ZC3H10 ZCCHC12 ZNF747	21 interacting genes: APPBP2 AQP2 BANP CDC37 CLTC CLTCL1 DNAJB11 DSCR9 FANCA HGS HMOX2 ITSN1 LAMTOR5 MESD MIB1 NRP1 OGT PFDN1 PRKRA PSMB8 RIGI
Entrez ID		10513	27131
HPRD ID		05616	10439
Ensembl ID		ENSG00000062725	ENSG00000089006
Uniprot IDs		Q92624	Q6P5V6 Q9Y5X3
PDB IDs		8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV	1SYS 5TGH 5TGI 5TGJ 5WY2 6N5X 6N5Y 6N5Z 8A1G 8ABQ 8AFZ
Enriched GO Terms of Interacting Partners?		Protein Binding	Cytoplasmic Vesicle Membrane Clathrin Coat Of Trans-Golgi Network Vesicle Endocytosis Clathrin Complex Receptor-mediated Endocytosis Clathrin Light Chain Binding Sorting Endosome Protein Localization To Lysosome Import Into Cell Double-stranded RNA Binding Clathrin-coated Pit Protein Folding Intracellular Protein Localization Protein Localization To Vacuole Cytoplasm Endosomal Transport Clathrin-coated Endocytic Vesicle Unfolded Protein Binding Cytoplasmic Vesicle Low-density Lipoprotein Particle Receptor Binding Recycling Endosome Clathrin-dependent Endocytosis Protein Folding Chaperone Complex Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Localization To Membrane Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Otic Placode Development Basal Dendrite Development
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