APPBP2 and CTC1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		APPBP2	CTC1
Description		amyloid beta precursor protein binding protein 2	CST telomere replication complex component 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Membrane Cytoplasmic Vesicle Membrane Cul2-RING Ubiquitin Ligase Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytosol CST Complex
	Molecular Function	Microtubule Motor Activity Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	DNA Binding Single-stranded DNA Binding Protein Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding
	Biological Process	Intracellular Protein Transport Protein Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Transport	Telomere Maintenance DNA Damage Response Regulation Of G2/M Transition Of Mitotic Cell Cycle Telomere Maintenance Via Telomere Lengthening Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Multicellular Organism Growth Positive Regulation Of DNA Replication Positive Regulation Of Fibroblast Proliferation Spleen Development Thymus Development Bone Marrow Development Chromosome Organization Hematopoietic Stem Cell Proliferation Replicative Senescence
Pathways			Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation
Drugs
Diseases
GWAS		Interleukin-6 levels ( 33517400) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-hip ratio ( 28552196)	Bipolar disorder ( 28115744) Telomere length ( 23001564)
Interacting Genes		122 interacting genes: - AADAC ACTN1 AHCY AIM2 AK3 ALDH1L1 ANKRD10 APP AR ARMCX5 ASCC3 ATP13A1 BCL7A BIN2 C1orf50 CALM3 CCDC167 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CST2 CTC1 CYBA DCD DHRS2 DHX16 DOLK DPEP1 DPYS EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GPRC5C GSTP1 H2AC15 HGFAC HIPK4 HSD3B7 HSPA4 ITGB4 ITGB5 KHK KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MAN2B2 MCOLN1 MGAT4B MLLT3 MMP28 MRPL28 MSH2 MSLN MUL1 MYLK NFYA NHERF1 NPRL3 PCSK5 PEX39 PI4KAP2 PNPLA5 PPIL6 PPP1R8 PRKAA2 PRKACB PSAP PTCH1 PYROXD2 RAB7B RASSF5 RHEB RILPL1 RNF128 RNF34 RNGTT RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SLC33A2 SLC7A10 SNX5 SPDYE2 SPDYE2B ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 TNP2 TRMT2A UBE2R2 UGGT2 WAS WDR24 WFIKKN1 WNT5B ZC3H10 ZCCHC12 ZNF747	2 interacting genes: APPBP2 TPP1
Entrez ID		10513	80169
HPRD ID		05616	07980
Ensembl ID		ENSG00000062725	ENSG00000178971
Uniprot IDs		Q92624	A0A8V8TP86 A0A8V8TQB6 J3KSZ1 Q2NKJ3
PDB IDs		8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV	5W2L 6W6W 7U5C 8D0B 8D0K 8SOJ 8SOK
Enriched GO Terms of Interacting Partners?		Protein Binding	Protein Localization To Chromosome, Telomeric Region Lysosomal Protein Catabolic Process Sulfatide Binding Peptide Catabolic Process Protein Catabolic Process Lysophosphatidic Acid Binding Tripeptidyl-peptidase Activity Protein Catabolic Process In The Vacuole Cul2-RING Ubiquitin Ligase Complex Bone Resorption Macromolecule Catabolic Process Peptide Binding Microtubule Associated Complex Proteolysis Neuromuscular Process Controlling Balance Lysosome Organization Peptide Metabolic Process Microtubule Motor Activity Protein Localization To Chromosome Intracellular Protein Localization Melanosome Neuromuscular Process Catabolic Process Endopeptidase Activity Lysosomal Lumen Ubiquitin-like Ligase-substrate Adaptor Activity Serine-type Peptidase Activity
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